Gene description for IBTK
Gene name inhibitor of Bruton agammaglobulinemia tyrosine kinase
Gene symbol IBTK
Other names/aliases BTBD26
Species Homo sapiens
 Database cross references - IBTK
ExoCarta ExoCarta_25998
Entrez Gene 25998
HGNC 17853
MIM 606457
UniProt Q9P2D0  
 IBTK identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for IBTK
Molecular Function
    protein kinase binding GO:0019901 IDA
    protein tyrosine kinase inhibitor activity GO:0030292 IDA
Biological Process
    negative regulation of protein phosphorylation GO:0001933 IDA
    negative regulation of protein tyrosine kinase activity GO:0061099 IDA
    release of sequestered calcium ion into cytosol GO:0051209 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IEA
 Experiment description of studies that identified IBTK in exosomes
Experiment ID 236
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for IBTK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BTK 695
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 RGS2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IBTK is involved
No pathways found

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