Gene description for PRKCG
Gene name protein kinase C, gamma
Gene symbol PRKCG
Other names/aliases PKC-gamma
PKCC
PKCG
SCA14
Species Homo sapiens
 Database cross references - PRKCG
ExoCarta ExoCarta_5582
Entrez Gene 5582
HGNC 9402
MIM 176980
UniProt P05129  
 PRKCG identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for PRKCG
Molecular Function
    protein kinase activity GO:0004672 IDA
    protein kinase C activity GO:0004697 TAS
    protein serine/threonine/tyrosine kinase activity GO:0004712 IDA
    ATP binding GO:0005524 IEA
    calcium-dependent protein kinase C activity GO:0004698 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    regulation of response to food GO:0032095 ISS
    synaptic transmission GO:0007268 TAS
    innervation GO:0060384 IEA
    negative regulation of protein catabolic process GO:0042177 IDA
    positive regulation of mismatch repair GO:0032425 IDA
    chemosensory behavior GO:0007635 IEA
    signal transduction GO:0007165 TAS
    blood coagulation GO:0007596 TAS
    phosphorylation GO:0016310 IDA
    activation of phospholipase C activity GO:0007202 TAS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    learning or memory GO:0007611 IEA
    platelet activation GO:0030168 TAS
    intracellular signal transduction GO:0035556 IEA
    negative regulation of proteasomal protein catabolic process GO:1901799 ISS
    protein phosphorylation GO:0006468 TAS
    rhythmic process GO:0048511 IEA
    response to pain GO:0048265 ISS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    protein autophosphorylation GO:0046777 IEA
    regulation of circadian rhythm GO:0042752 ISS
    innate immune response GO:0045087 TAS
    negative regulation of protein ubiquitination GO:0031397 IDA
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    response to morphine GO:0043278 ISS
Subcellular Localization
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 ISS
    synaptic membrane GO:0097060 IEA
    nucleus GO:0005634 IEA
    plasma membrane GO:0005886 ISS
    dendrite GO:0030425 ISS
    cell-cell junction GO:0005911 IEA
 Experiment description of studies that identified PRKCG in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for PRKCG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GABRA4  
Invivo Homo sapiens
2 GABRA1  
Invivo Homo sapiens
3 YWHAG 7532
Affinity Capture-Western Homo sapiens
4 PDLIM5 10611
Two-hybrid Homo sapiens
5 AFAP1 60312
Invitro Homo sapiens
6 TIAM1  
Invitro Homo sapiens
7 GRIA4  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
8 RGS2  
Invivo Homo sapiens
Invitro Homo sapiens
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