Gene description for Ruvbl1
Gene name RuvB-like protein 1
Gene symbol Ruvbl1
Other names/aliases 2510009G06Rik
Pontin52
Tip49a
Species Mus musculus
 Database cross references - Ruvbl1
ExoCarta ExoCarta_56505
Entrez Gene 56505
UniProt P60122  
 Ruvbl1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Ruvbl1
Molecular Function
    nucleotide binding GO:0000166 IEA
    helicase activity GO:0004386 IEA
    ATP-dependent 3'-5' DNA helicase activity GO:0043140 ISO
    ATP binding GO:0005524 IEA
    hydrolase activity GO:0016787 IEA
    DNA helicase activity GO:0003678 ISO
    ATP-dependent 5'-3' DNA helicase activity GO:0043141 IEA
Biological Process
    DNA repair GO:0006281 IEA
    positive regulation of protein targeting to mitochondrion GO:1903955 ISO
    cell cycle GO:0007049 IEA
    mitotic nuclear division GO:0007067 IEA
    regulation of fibroblast apoptotic process GO:2000269 ISO
    DNA duplex unwinding GO:0032508 ISO
    chromatin modification GO:0016568 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    histone H2A acetylation GO:0043968 ISO
    positive regulation of plasminogen activation GO:0010756 ISO
    regulation of growth GO:0040008 IEA
    histone H4 acetylation GO:0043967 ISO
    cellular response to DNA damage stimulus GO:0006974 IEA
    regulation of mitochondrion degradation GO:1903146 ISO
    DNA recombination GO:0006310 IEA
    transcription, DNA-templated GO:0006351 IEA
    cell division GO:0051301 IEA
Subcellular Localization
    Swr1 complex GO:0000812 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    MLL1 complex GO:0071339 ISO
    nucleus GO:0005634 ISO
    NuA4 histone acetyltransferase complex GO:0035267 ISO
    nucleoplasm GO:0005654 ISO
    Ino80 complex GO:0031011 ISO
    nuclear matrix GO:0016363 ISO
    protein complex GO:0043234 ISO
    ribonucleoprotein complex GO:0030529 IDA
    extracellular exosome GO:0070062 ISO
    Golgi apparatus GO:0005794 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Ruvbl1 in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ruvbl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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