Gene description for Ighmbp2
Gene name immunoglobulin mu binding protein 2
Gene symbol Ighmbp2
Other names/aliases AEP
Catf1
RIPE3b1
Smbp-2
Smbp2
Smubp2
nmd
sma
Species Mus musculus
 Database cross references - Ighmbp2
ExoCarta ExoCarta_20589
Entrez Gene 20589
 Ighmbp2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ighmbp2
Molecular Function
    ATP binding GO:0005524 ISO
    ribosome binding GO:0043022 ISO
    nucleotide binding GO:0000166 IEA
    nucleic acid binding GO:0003676 IEA
    tRNA binding GO:0000049 ISO
    transcription factor binding GO:0008134 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 ISO
    ATP-dependent 5'-3' RNA helicase activity GO:0032575 ISO
    metal ion binding GO:0046872 IEA
    DNA-dependent ATPase activity GO:0008094 ISO
    DNA binding GO:0003677 ISO
    hydrolase activity GO:0016787 IEA
    helicase activity GO:0004386 IEA
    zinc ion binding GO:0008270 IEA
    ATP-dependent 5'-3' DNA helicase activity GO:0043141 ISO
    RNA binding GO:0003723 ISO
    RNA-dependent ATPase activity GO:0008186 ISO
Biological Process
    DNA duplex unwinding GO:0032508 ISO
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription from RNA polymerase II promoter GO:0006366 ISO
    translation GO:0006412 NAS
    spinal cord motor neuron differentiation GO:0021522 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    protein homooligomerization GO:0051260 ISO
Subcellular Localization
    ribonucleoprotein complex GO:0030529 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 ISO
    growth cone GO:0030426 IDA
    cell projection GO:0042995 IEA
    axon GO:0030424 IDA
    nucleus GO:0005634 ISO
    neuronal cell body GO:0043025 IDA
 Experiment description of studies that identified Ighmbp2 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ighmbp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ighmbp2 is involved
No pathways found





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