Gene description for Ighmbp2
Gene name immunoglobulin mu binding protein 2
Gene symbol Ighmbp2
Other names/aliases AEP
Catf1
RIPE3b1
Smbp-2
Smbp2
Smubp2
nmd
sma
Species Mus musculus
 Database cross references - Ighmbp2
ExoCarta ExoCarta_20589
Vesiclepedia VP_20589
Entrez Gene 20589
 Ighmbp2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ighmbp2
Molecular Function
    tRNA binding GO:0000049 ISO
    tRNA binding GO:0000049 ISS
    DNA binding GO:0003677 ISO
    DNA clamp loader activity GO:0003689 IEA
    single-stranded DNA binding GO:0003697 ISO
    RNA binding GO:0003723 ISO
    RNA binding GO:0003723 ISS
    single-stranded RNA binding GO:0003727 IDA
    single-stranded RNA binding GO:0003727 ISO
    ATP binding GO:0005524 ISO
    ATP binding GO:0005524 ISS
    ATP-dependent activity, acting on DNA GO:0008094 ISO
    ATP-dependent activity, acting on DNA GO:0008094 ISS
    transcription factor binding GO:0008134 ISO
    ATP-dependent activity, acting on RNA GO:0008186 ISO
    ATP-dependent activity, acting on RNA GO:0008186 ISS
    zinc ion binding GO:0008270 IEA
    four-way junction helicase activity GO:0009378 IEA
    ATP hydrolysis activity GO:0016887 IDA
    ATP hydrolysis activity GO:0016887 ISO
    5'-3' RNA helicase activity GO:0032574 ISO
    5'-3' RNA helicase activity GO:0032574 ISS
    double-stranded DNA helicase activity GO:0036121 ISO
    double-stranded DNA helicase activity GO:0036121 ISS
    identical protein binding GO:0042802 ISO
    ribosome binding GO:0043022 IDA
    ribosome binding GO:0043022 ISO
    5'-3' DNA helicase activity GO:0043139 IBA
    5'-3' DNA helicase activity GO:0043139 ISO
    5'-3' DNA helicase activity GO:0043139 ISS
    forked DNA-dependent helicase activity GO:0061749 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
    single-stranded 3'-5' DNA helicase activity GO:1990518 IEA
    G-rich single-stranded DNA binding GO:1990955 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    chromatin remodeling GO:0006338 IEA
    translation GO:0006412 NAS
    RNA secondary structure unwinding GO:0010501 ISO
    spinal cord motor neuron differentiation GO:0021522 IMP
    DNA duplex unwinding GO:0032508 ISO
    DNA duplex unwinding GO:0032508 ISS
    neuromuscular process GO:0050905 IMP
    chromatin looping GO:0140588 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    nuclear body GO:0016604 ISO
    axon GO:0030424 IDA
    growth cone GO:0030426 IDA
    neuronal cell body GO:0043025 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    ribonucleoprotein complex GO:1990904 IDA
 Experiment description of studies that identified Ighmbp2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ighmbp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ighmbp2 20589
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
2 Hnrnph1 59013
Affinity Capture-MS Mus musculus
3 Hspa1b 15511
Affinity Capture-MS Mus musculus
4 Slit3 20564
Co-localization Mus musculus
5 Ruvbl2 20174
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
6 Gtf3c1  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
7 Tyr  
Affinity Capture-RNA Mus musculus
8 Ruvbl1 56505
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
9 Zbtb14  
Affinity Capture-MS Mus musculus
10 Abt1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
11 Robo1  
Co-localization Mus musculus
View the network image/svg+xml
 Pathways in which Ighmbp2 is involved
No pathways found





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