Gene description for Wdr1
Gene name WD repeat domain 1
Gene symbol Wdr1
Other names/aliases Aip1
D5Wsu185e
rede
Species Mus musculus
 Database cross references - Wdr1
ExoCarta ExoCarta_22388
Entrez Gene 22388
UniProt O88342  
 Wdr1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Wdr1
Molecular Function
    actin binding GO:0003779 ISA
Biological Process
    sensory perception of sound GO:0007605 ISA
    positive regulation of actin filament depolymerization GO:0030836 IGI
    regulation of oligodendrocyte differentiation GO:0048713 ISO
    sarcomere organization GO:0045214 IMP
    actin cytoskeleton organization GO:0030036 IMP
    regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 IMP
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    cell projection GO:0042995 IEA
    myelin sheath GO:0043209 IDA
    actin filament GO:0005884 ISO
    cell junction GO:0030054 IEA
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 IEA
    actin cytoskeleton GO:0015629 ISA
 Experiment description of studies that identified Wdr1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Wdr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Wdr1 is involved
PathwayEvidenceSource
Platelet degranulation IEA Reactome





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