Gene description for Rbbp7
Gene name retinoblastoma binding protein 7
Gene symbol Rbbp7
Other names/aliases AA409861
AI173248
AU019541
BB114024
mRbAp46
Species Mus musculus
 Database cross references - Rbbp7
ExoCarta ExoCarta_245688
Vesiclepedia VP_245688
Entrez Gene 245688
UniProt Q60973  
 Rbbp7 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rbbp7
Molecular Function
    RNA binding GO:0003723 IPI
    protein binding GO:0005515 IPI
    histone binding GO:0042393 IBA
    histone binding GO:0042393 IEA
    histone binding GO:0042393 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 NAS
    DNA replication GO:0006260 IEA
    chromatin remodeling GO:0006338 IBA
    chromatin remodeling GO:0006338 ISO
    chromatin remodeling GO:0006338 TAS
    regulation of DNA-templated transcription GO:0006355 IBA
    regulation of DNA-templated transcription GO:0006355 ISO
    brain development GO:0007420 NAS
    negative regulation of cell growth GO:0030308 ISO
    negative regulation of cell growth GO:0030308 ISS
    negative regulation of cell migration GO:0030336 NAS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 NAS
    regulation of cell fate specification GO:0042659 NAS
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    response to steroid hormone GO:0048545 IEA
    cellular heat acclimation GO:0070370 ISO
    cellular heat acclimation GO:0070370 ISS
    negative regulation of stem cell population maintenance GO:1902455 NAS
    positive regulation of stem cell population maintenance GO:1902459 NAS
    regulation of stem cell differentiation GO:2000736 NAS
Subcellular Localization
    histone deacetylase complex GO:0000118 ISO
    chromosome, telomeric region GO:0000781 IEA
    chromosome, telomeric region GO:0000781 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    NuRD complex GO:0016581 IBA
    NuRD complex GO:0016581 IDA
    NuRD complex GO:0016581 ISO
    NuRD complex GO:0016581 ISS
    NuRD complex GO:0016581 NAS
    NURF complex GO:0016589 ISO
    ESC/E(Z) complex GO:0035098 IBA
    ESC/E(Z) complex GO:0035098 IDA
    ESC/E(Z) complex GO:0035098 ISO
    ESC/E(Z) complex GO:0035098 ISS
    Sin3-type complex GO:0070822 NAS
    ATPase complex GO:1904949 ISO
 Experiment description of studies that identified Rbbp7 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rbbp7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Adss  
Co-fractionation Mus musculus
3 Hspa8 15481
Co-fractionation Mus musculus
4 HIST1H3A 8350
Affinity Capture-MS Homo sapiens
5 Pou5f1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
6 Hdac2  
Affinity Capture-Western Mus musculus
7 Wdr1 22388
Co-fractionation Mus musculus
8 Gata1  
Affinity Capture-Western Mus musculus
9 Atxn1  
Affinity Capture-MS Mus musculus
10 Cul4a  
Co-fractionation Mus musculus
11 Tfe3  
Affinity Capture-MS Mus musculus
12 Suz12  
Affinity Capture-MS Mus musculus
13 Chaf1a  
Affinity Capture-MS Mus musculus
14 Idh1 15926
Co-fractionation Mus musculus
15 Ezh2  
Affinity Capture-MS Mus musculus
16 Hdac1 433759
Two-hybrid Mus musculus
17 Mettl21e  
Affinity Capture-MS Mus musculus
18 Mta1  
Affinity Capture-Western Mus musculus
19 Zfpm1  
Affinity Capture-MS Mus musculus
20 Mta2 23942
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
21 Nanog  
Affinity Capture-Western Mus musculus
22 Thop1  
Co-fractionation Mus musculus
23 Tfcp2l1  
Affinity Capture-MS Mus musculus
24 Tet2  
Affinity Capture-MS Mus musculus
25 Sumo1  
Affinity Capture-Western Mus musculus
26 Rnf2  
Affinity Capture-MS Mus musculus
27 Zbtb7b  
Affinity Capture-MS Mus musculus
28 Eftud2 20624
Co-fractionation Mus musculus
29 Rbbp4 19646
Co-fractionation Mus musculus
30 Eed  
Affinity Capture-MS Mus musculus
31 Tet1  
Affinity Capture-MS Mus musculus
32 Atg16l1  
Affinity Capture-MS Mus musculus
33 Sall4  
Affinity Capture-MS Mus musculus
34 Fancd2  
Affinity Capture-MS Mus musculus
35 Tcf3  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Rbbp7 is involved
PathwayEvidenceSource
Cell Cycle IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence IEA Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance IEA Reactome
Deposition of new CENPA-containing nucleosomes at the centromere IEA Reactome
Epigenetic regulation of gene expression IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones IEA Reactome
HDACs deacetylate histones IEA Reactome
Intracellular signaling by second messengers IEA Reactome
Metabolism of proteins IEA Reactome
Neddylation IEA Reactome
Nucleosome assembly IEA Reactome
Oxidative Stress Induced Senescence IEA Reactome
PIP3 activates AKT signaling IEA Reactome
PKMTs methylate histone lysines IEA Reactome
Post-translational protein modification IEA Reactome
PRC2 methylates histones and DNA IEA Reactome
PTEN Regulation IEA Reactome
Regulation of PTEN gene transcription IEA Reactome
Regulation of TP53 Activity IEA Reactome
Regulation of TP53 Activity through Acetylation IEA Reactome
RMTs methylate histone arginines IEA Reactome
RNA Polymerase I Promoter Clearance IEA Reactome
RNA Polymerase I Transcription IEA Reactome
RNA Polymerase I Transcription Initiation IEA Reactome
RNA Polymerase II Transcription IEA Reactome
Signal Transduction IEA Reactome
Transcriptional Regulation by E2F6 IEA Reactome
Transcriptional Regulation by TP53 IEA Reactome





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