Gene description for Idh1
Gene name isocitrate dehydrogenase 1 (NADP+), soluble
Gene symbol Idh1
Other names/aliases AI314845
AI788952
E030024J03Rik
Id-1
Idh-1
Idpc
Species Mus musculus
 Database cross references - Idh1
ExoCarta ExoCarta_15926
Vesiclepedia VP_15926
Entrez Gene 15926
UniProt O88844  
 Idh1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Idh1
Molecular Function
    metal ion binding GO:0046872 IEA
    NAD binding GO:0051287 IEA
    magnesium ion binding GO:0000287 ISO
    NADP binding GO:0050661 ISO
    isocitrate dehydrogenase (NADP+) activity GO:0004450 ISO
    protein homodimerization activity GO:0042803 ISO
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 IEA
    oxidoreductase activity GO:0016491 IEA
    receptor binding GO:0005102 ISO
Biological Process
    tricarboxylic acid cycle GO:0006099 IEA
    regulation of phospholipid catabolic process GO:0060696 IMP
    glyoxylate cycle GO:0006097 IEA
    isocitrate metabolic process GO:0006102 ISO
    response to organic cyclic compound GO:0014070 ISO
    glutathione metabolic process GO:0006749 IMP
    response to steroid hormone GO:0048545 ISO
    regulation of phospholipid biosynthetic process GO:0071071 IMP
    2-oxoglutarate metabolic process GO:0006103 ISO
    response to oxidative stress GO:0006979 IDA
    oxidation-reduction process GO:0055114 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 ISO
    cytoplasm GO:0005737 ISO
    peroxisome GO:0005777 ISO
 Experiment description of studies that identified Idh1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Idh1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Idh1 is involved
PathwayEvidenceSource
NADPH regeneration IEA Reactome





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