Gene description for Ranbp1
Gene name RAN binding protein 1
Gene symbol Ranbp1
Other names/aliases Htf9a
Species Mus musculus
 Database cross references - Ranbp1
ExoCarta ExoCarta_19385
Vesiclepedia VP_19385
Entrez Gene 19385
UniProt P34022  
 Ranbp1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Pancreatic cells 19351151    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ranbp1
Molecular Function
    GTPase activator activity GO:0005096 IBA
    GTPase activator activity GO:0005096 IEA
Biological Process
    nucleocytoplasmic transport GO:0006913 IEA
    spindle organization GO:0007051 IDA
    positive regulation of neuron projection development GO:0010976 ISO
    positive regulation of mitotic centrosome separation GO:0046604 IBA
    positive regulation of mitotic centrosome separation GO:0046604 IDA
    cellular response to leptomycin B GO:0072750 ISO
Subcellular Localization
    nuclear pore GO:0005643 IBA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane bounded cell projection cytoplasm GO:0032838 ISO
    axon cytoplasm GO:1904115 ISO
 Experiment description of studies that identified Ranbp1 in exosomes
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ranbp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COMMD10 51397
Affinity Capture-MS Homo sapiens
2 Nap1l1 53605
Co-fractionation Mus musculus
3 Rangrf  
Co-fractionation Mus musculus
4 FAM45A 404636
Affinity Capture-MS Homo sapiens
5 COMMD4 54939
Affinity Capture-MS Homo sapiens
6 Rcc1  
Co-fractionation Mus musculus
7 COMMD8 54951
Affinity Capture-MS Homo sapiens
8 COMMD5 28991
Affinity Capture-MS Homo sapiens
9 KPNB1 3837
Affinity Capture-MS Homo sapiens
10 Atxn1  
Affinity Capture-MS Mus musculus
11 Ptma  
Co-fractionation Mus musculus
12 COMMD2 51122
Affinity Capture-MS Homo sapiens
13 DSCR3 10311
Affinity Capture-MS Homo sapiens
14 Iqcb1  
Affinity Capture-MS Mus musculus
15 Idh1 15926
Co-fractionation Mus musculus
16 CCDC93 54520
Affinity Capture-MS Homo sapiens
17 VPS29 51699
Affinity Capture-MS Homo sapiens
18 C16orf62 57020
Affinity Capture-MS Homo sapiens
19 Rangap1  
Co-fractionation Mus musculus
20 Ran 19384
Co-fractionation Mus musculus
21 RAN 5901
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
22 COMMD6 170622
Affinity Capture-MS Homo sapiens
23 COMMD9 29099
Affinity Capture-MS Homo sapiens
24 PGAP2  
Affinity Capture-MS Homo sapiens
25 CCDC22 28952
Affinity Capture-MS Homo sapiens
26 TFIP11  
Affinity Capture-MS Homo sapiens
27 COMMD3 23412
Affinity Capture-MS Homo sapiens
28 RCC1 1104
Affinity Capture-MS Homo sapiens
29 COMMD1 150684
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Ranbp1 is involved
No pathways found





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