Gene description for COMMD2
Gene name COMM domain containing 2
Gene symbol COMMD2
Other names/aliases HSPC042
Species Homo sapiens
 Database cross references - COMMD2
ExoCarta ExoCarta_51122
Vesiclepedia VP_51122
Entrez Gene 51122
HGNC 24993
UniProt Q86X83  
 COMMD2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for COMMD2
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified COMMD2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COMMD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COMMD10 51397
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 APP 351
Reconstituted Complex Homo sapiens
3 TRIM16L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SUPT16H 11198
Affinity Capture-MS Homo sapiens
5 ARHGAP17 55114
Co-fractionation Homo sapiens
6 RELA 5970
Affinity Capture-Western Homo sapiens
7 COMMD3-BMI1 100532731
Affinity Capture-MS Homo sapiens
8 MYO1C 4641
Affinity Capture-MS Homo sapiens
9 CCDC151  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
11 CNGA4  
Affinity Capture-MS Homo sapiens
12 FAM45A 404636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 OR13G1  
Affinity Capture-MS Homo sapiens
14 Ranbp1 19385
Affinity Capture-MS Mus musculus
15 SRSF6 6431
Affinity Capture-MS Homo sapiens
16 CTAGE5 4253
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CHERP 10523
Affinity Capture-MS Homo sapiens
18 STMN2  
Affinity Capture-MS Homo sapiens
19 CCDC114  
Affinity Capture-MS Homo sapiens
20 LAMP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 PAK3  
Affinity Capture-MS Homo sapiens
22 C15orf59  
Affinity Capture-MS Homo sapiens
23 DYNC1I2 1781
Proximity Label-MS Homo sapiens
24 COMMD8 54951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 COMMD5 28991
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NUP62 23636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 ASIC4  
Affinity Capture-MS Homo sapiens
28 SUB1 10923
Affinity Capture-MS Homo sapiens
29 COMMD7 149951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PCBP2 5094
Affinity Capture-MS Homo sapiens
31 COMMD9 29099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 EFNB1 1947
Affinity Capture-MS Homo sapiens
33 CWF19L2  
Affinity Capture-MS Homo sapiens
34 RBMX2  
Affinity Capture-MS Homo sapiens
35 CNKSR3 154043
Affinity Capture-MS Homo sapiens
36 CCDC93 54520
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SPACA1 81833
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 VPS29 51699
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ITPR3 3710
Affinity Capture-MS Homo sapiens
40 LRRC25  
Affinity Capture-MS Homo sapiens
41 FAT3 120114
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 C16orf62 57020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 USP8 9101
Co-fractionation Homo sapiens
44 AP3D1 8943
Affinity Capture-MS Homo sapiens
45 SULF2 55959
Affinity Capture-MS Homo sapiens
46 PSPC1 55269
Affinity Capture-MS Homo sapiens
47 SKIV2L2 23517
Affinity Capture-MS Homo sapiens
48 MCMBP 79892
Co-fractionation Homo sapiens
49 COMMD6 170622
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 DHRS7B 25979
Affinity Capture-MS Homo sapiens
51 TIPRL 261726
Co-fractionation Homo sapiens
52 RELB  
Affinity Capture-Western Homo sapiens
53 DSCR3 10311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 NFKB1 4790
Affinity Capture-Western Homo sapiens
55 CCDC97  
Affinity Capture-MS Homo sapiens
56 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 EZR 7430
Co-fractionation Homo sapiens
58 C3orf18  
Affinity Capture-MS Homo sapiens
59 CCDC22 28952
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 ARGLU1  
Affinity Capture-MS Homo sapiens
61 TRIM72  
Affinity Capture-MS Homo sapiens
62 SSRP1 6749
Affinity Capture-MS Homo sapiens
63 NFKB2 4791
Affinity Capture-Western Homo sapiens
64 COMMD4 54939
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 RSRC1  
Affinity Capture-MS Homo sapiens
66 COMMD3 23412
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
67 KIF2B 84643
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 RBM17 84991
Affinity Capture-MS Homo sapiens
69 COMMD1 150684
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 U2SURP 23350
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which COMMD2 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Neddylation TAS Reactome
Post-translational protein modification TAS Reactome





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