Gene description for CCDC22
Gene name coiled-coil domain containing 22
Gene symbol CCDC22
Other names/aliases CXorf37
JM1
Species Homo sapiens
 Database cross references - CCDC22
ExoCarta ExoCarta_28952
Entrez Gene 28952
HGNC 28909
MIM 300859
UniProt O60826  
 CCDC22 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CCDC22
Molecular Function
    cullin family protein binding GO:0097602 IDA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 IMP
    cytoplasmic sequestering of NF-kappaB GO:0007253 IMP
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IMP
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IMP
    protein transport GO:0015031 IEA
    Golgi to plasma membrane transport GO:0006893 IMP
    cellular copper ion homeostasis GO:0006878 IMP
Subcellular Localization
    endosome GO:0005768 IEA
    cellular_component GO:0005575 ND
 Experiment description of studies that identified CCDC22 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CCDC22
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CPNE1 8904
Affinity Capture-MS Homo sapiens
2 CPNE4 131034
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CCDC22 is involved
No pathways found





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