Gene description for FAM21C
Gene name family with sequence similarity 21, member C
Gene symbol FAM21C
Other names/aliases FAM21A
VPEF
Species Homo sapiens
 Database cross references - FAM21C
ExoCarta ExoCarta_253725
Entrez Gene 253725
HGNC 23414
MIM 613631
UniProt Q9Y4E1  
 FAM21C identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FAM21C
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-5-phosphate binding GO:0010314 IDA
    phosphatidylinositol-3-phosphate binding GO:0032266 IDA
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IDA
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IDA
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 IDA
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IDA
    phosphatidylinositol-4-phosphate binding GO:0070273 IDA
Biological Process
    retrograde transport, endosome to Golgi GO:0042147 IMP
    protein transport GO:0015031 IEA
    negative regulation of barbed-end actin filament capping GO:2000813 IDA
    regulation of substrate adhesion-dependent cell spreading GO:1900024 IDA
    retrograde transport, endosome to plasma membrane GO:1990126 IMP
Subcellular Localization
    WASH complex GO:0071203 IDA
    early endosome GO:0005769 IDA
    endosome GO:0005768 IDA
    early endosome membrane GO:0031901 IEA
    retromer complex GO:0030904 IDA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified FAM21C in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FAM21C
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FAM21C is involved
No pathways found





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