Gene description for C17orf59
Gene name chromosome 17 open reading frame 59
Gene symbol C17orf59
Other names/aliases PRO2472
Species Homo sapiens
 Database cross references - C17orf59
ExoCarta ExoCarta_54785
Vesiclepedia VP_54785
Entrez Gene 54785
HGNC 25939
UniProt Q96GS4  
 C17orf59 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for C17orf59
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    lysosome localization GO:0032418 IBA
    lysosome localization GO:0032418 IMP
    lysosome localization GO:0032418 NAS
    regulation of endosome size GO:0051036 NAS
    regulation of lysosome size GO:0062196 NAS
    organelle transport along microtubule GO:0072384 NAS
Subcellular Localization
    cytoplasmic side of lysosomal membrane GO:0098574 NAS
    BORC complex GO:0099078 IBA
    BORC complex GO:0099078 IDA
    BORC complex GO:0099078 IPI
 Experiment description of studies that identified C17orf59 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for C17orf59
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPATS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LYPD3 27076
Affinity Capture-MS Homo sapiens
3 CAMSAP1 157922
Proximity Label-MS Homo sapiens
4 RINT1 60561
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CEP89 84902
Proximity Label-MS Homo sapiens
6 SOGA1 140710
Proximity Label-MS Homo sapiens
7 LAMP3  
Proximity Label-MS Homo sapiens
8 HSBP1 3281
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 RAB9A 9367
Proximity Label-MS Homo sapiens
10 NUP62 23636
Proximity Label-MS Homo sapiens
11 KIF20A 10112
Proximity Label-MS Homo sapiens
12 PSMC3 5702
Proximity Label-MS Homo sapiens
13 UQCRB 7381
Affinity Capture-MS Homo sapiens
14 EPS8 2059
Two-hybrid Homo sapiens
15 LAMP2 3920
Proximity Label-MS Homo sapiens
16 CAMSAP2  
Proximity Label-MS Homo sapiens
17 ATP6V0C 527
Affinity Capture-MS Homo sapiens
18 ANKRD28 23243
Proximity Label-MS Homo sapiens
19 SELT 51714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TACC2 10579
Two-hybrid Homo sapiens
21 PIBF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 UQCRQ 27089
Affinity Capture-MS Homo sapiens
23 NDC80 10403
Proximity Label-MS Homo sapiens
24 WTAP 9589
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
25 BLOC1S1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SCLT1 132320
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 NDE1 54820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 FAM175A  
Proximity Label-MS Homo sapiens
29 IFT74 80173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 DGKH 160851
Proximity Label-MS Homo sapiens
31 OSBPL9 114883
Proximity Label-MS Homo sapiens
32 CCDC14  
Proximity Label-MS Homo sapiens
33 GSTM5 2949
Affinity Capture-MS Homo sapiens
34 NAV1 89796
Proximity Label-MS Homo sapiens
35 TRIOBP 11078
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SDCCAG3  
Proximity Label-MS Homo sapiens
37 HGS 9146
Two-hybrid Homo sapiens
38 TRIM56 81844
Proximity Label-MS Homo sapiens
39 PPP6R1 22870
Proximity Label-MS Homo sapiens
40 PSMC2 5701
Proximity Label-MS Homo sapiens
41 LAMTOR3 8649
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 KTN1 3895
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 GOPC 57120
Proximity Label-MS Homo sapiens
44 CCDC18  
Proximity Label-MS Homo sapiens
45 RGPD6  
Proximity Label-MS Homo sapiens
46 ZWINT  
Proximity Label-MS Homo sapiens
47 LAMTOR4 389541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 PKNOX1  
Two-hybrid Homo sapiens
49 KNSTRN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 LOH12CR1 118426
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 RCOR3  
Two-hybrid Homo sapiens
52 HAUS4  
Proximity Label-MS Homo sapiens
53 LAMTOR1 55004
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 IFT20 90410
Proximity Label-MS Homo sapiens
55 C1orf216  
Two-hybrid Homo sapiens
56 C15orf59  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
57 PPM1B 5495
Affinity Capture-MS Homo sapiens
58 SPAG5 10615
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 BEX2  
Two-hybrid Homo sapiens
60 SHPRH  
Two-hybrid Homo sapiens
61 CEP55 55165
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
62 FAM161B  
Two-hybrid Homo sapiens
63 LUZP1 7798
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 MOS 4342
Two-hybrid Homo sapiens
65 TBKBP1  
Proximity Label-MS Homo sapiens
66 VPS51 738
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 CEP192 55125
Proximity Label-MS Homo sapiens
68 FAM9C  
Two-hybrid Homo sapiens
69 EXOC4 60412
Proximity Label-MS Homo sapiens
70 OFD1 8481
Proximity Label-MS Homo sapiens
71 ABI2 10152
Two-hybrid Homo sapiens
72 DTNBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
73 BLOC1S5 63915
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 CAMSAP3  
Proximity Label-MS Homo sapiens
75 HAUS8  
Proximity Label-MS Homo sapiens
76 WDYHV1  
Two-hybrid Homo sapiens
77 SIPA1L2  
Proximity Label-MS Homo sapiens
78 ZNF655  
Two-hybrid Homo sapiens
79 KIF11 3832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
80 UQCRC1 7384
Affinity Capture-MS Homo sapiens
81 CCDC22 28952
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
82 EXOG 9941
Affinity Capture-MS Homo sapiens
83 MEF2BNB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 UQCRH 7388
Affinity Capture-MS Homo sapiens
85 GOLGB1 2804
Affinity Capture-MS Homo sapiens
86 SNAP29 9342
Proximity Label-MS Homo sapiens
87 NCKAP5L  
Proximity Label-MS Homo sapiens
88 DISC1 27185
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 NUP88 4927
Proximity Label-MS Homo sapiens
90 RNF40 9810
Affinity Capture-MS Homo sapiens
91 HIST1H3F 8968
Proximity Label-MS Homo sapiens
92 TSSC1 7260
Affinity Capture-MS Homo sapiens
93 RAB7A 7879
Proximity Label-MS Homo sapiens
94 PLA2G4A 5321
Two-hybrid Homo sapiens
95 BAG2 9532
Proximity Label-MS Homo sapiens
96 CCDC57 284001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 C1orf109  
Two-hybrid Homo sapiens
98 TRAF3IP1 26146
Proximity Label-MS Homo sapiens
99 IFT57 55081
Proximity Label-MS Homo sapiens
100 LAMTOR2 28956
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 UQCC3  
Affinity Capture-MS Homo sapiens
102 THOC7 80145
Proximity Label-MS Homo sapiens
103 OSTF1 26578
Two-hybrid Homo sapiens
104 UACA 55075
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 SASS6 163786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 CDK5RAP2 55755
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 CEP164  
Proximity Label-MS Homo sapiens
108 HAUS5 23354
Proximity Label-MS Homo sapiens
109 CEP250 11190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 ANKRD52 283373
Proximity Label-MS Homo sapiens
111 CCDC77  
Affinity Capture-MS Homo sapiens
112 BICD2 23299
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 NIN 51199
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 CNTROB  
Proximity Label-MS Homo sapiens
115 FCHSD2  
Two-hybrid Homo sapiens
116 RIBC1  
Two-hybrid Homo sapiens
117 CEP131 22994
Proximity Label-MS Homo sapiens
118 SIRT2 22933
Proximity Label-MS Homo sapiens
119 USHBP1  
Two-hybrid Homo sapiens
120 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
121 KIF3A 11127
Proximity Label-MS Homo sapiens
122 TACC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 MPHOSPH9  
Proximity Label-MS Homo sapiens
124 XXYLT1 152002
Affinity Capture-MS Homo sapiens
125 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 FGL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 HAUS1  
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
128 CYTB  
Affinity Capture-MS Homo sapiens
129 BLOC1S2 282991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 EXOC8 149371
Two-hybrid Homo sapiens
131 CCHCR1  
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 VPS52 6293
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
133 INPPL1 3636
Proximity Label-MS Homo sapiens
134 PEX19 5824
Proximity Label-MS Homo sapiens
135 DNAJA2 10294
Proximity Label-MS Homo sapiens
136 ODF2L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 FAM184A 79632
Affinity Capture-MS Homo sapiens
138 DCTN2 10540
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
139 FYCO1 79443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 CCDC122  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 SNAPIN 23557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 FBXO44  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
143 C19orf25  
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
144 GAS8  
Two-hybrid Homo sapiens
145 C10orf32  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 TBK1 29110
Proximity Label-MS Homo sapiens
147 UBB 7314
Proximity Label-MS Homo sapiens
148 MED21  
Two-hybrid Homo sapiens
149 TRIM37  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 STXBP4 252983
Proximity Label-MS Homo sapiens
151 CEP135  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 MYPOP  
Affinity Capture-MS Homo sapiens
153 KANK2 25959
Two-hybrid Homo sapiens
154 KXD1 79036
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 NDEL1 81565
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 CDR2  
Proximity Label-MS Homo sapiens
157 SNX2 6643
Proximity Label-MS Homo sapiens
158 PCNT  
Proximity Label-MS Homo sapiens
159 CLIP2 7461
Affinity Capture-MS Homo sapiens
160 CEP170 9859
Affinity Capture-MS Homo sapiens
161 FAM21A 387680
Proximity Label-MS Homo sapiens
162 HSPA1B 3304
Proximity Label-MS Homo sapiens
163 C17orf59 54785
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which C17orf59 is involved
No pathways found





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