Gene description for SELT
Gene name selenoprotein T
Gene symbol SELT
Other names/aliases -
Species Homo sapiens
 Database cross references - SELT
ExoCarta ExoCarta_51714
Vesiclepedia VP_51714
Entrez Gene 51714
MIM 607912
UniProt P62341  
 SELT identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SELT
Molecular Function
    thioredoxin-disulfide reductase (NADPH) activity GO:0004791 IBA
    thioredoxin-disulfide reductase (NADPH) activity GO:0004791 ISS
    selenium binding GO:0008430 NAS
Biological Process
    selenocysteine incorporation GO:0001514 NAS
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISS
    response to glucose GO:0009749 ISS
    pancreas development GO:0031016 ISS
    insulin secretion involved in cellular response to glucose stimulus GO:0035773 ISS
    glucose homeostasis GO:0042593 ISS
    cell redox homeostasis GO:0045454 IBA
    cell redox homeostasis GO:0045454 IDA
    positive regulation of growth hormone secretion GO:0060124 ISS
    cellular oxidant detoxification GO:0098869 ISS
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISS
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 ISS
 Experiment description of studies that identified SELT in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SELT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC39A12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HBB 3043
Two-hybrid Homo sapiens
3 PPP4C 5531
Affinity Capture-MS Homo sapiens
4 SV2A 9900
Affinity Capture-MS Homo sapiens
5 SLC2A12 154091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 DNAJB12 54788
Proximity Label-MS Homo sapiens
7 SIDT2 51092
Affinity Capture-MS Homo sapiens
8 LRRC59 55379
Proximity Label-MS Homo sapiens
9 SCPEP1 59342
Affinity Capture-MS Homo sapiens
10 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TEX28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 EIF2B2 8892
Affinity Capture-MS Homo sapiens
13 ARSE 415
Affinity Capture-MS Homo sapiens
14 GJA8  
Affinity Capture-MS Homo sapiens
15 HCRTR2  
Affinity Capture-MS Homo sapiens
16 ICA1  
Affinity Capture-MS Homo sapiens
17 NIPAL1  
Affinity Capture-MS Homo sapiens
18 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
19 SLC5A6 8884
Affinity Capture-MS Homo sapiens
20 KEL  
Affinity Capture-MS Homo sapiens
21 CNPY3 10695
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 NCLN 56926
Affinity Capture-MS Homo sapiens
24 TIGD3  
Affinity Capture-MS Homo sapiens
25 SCN4A  
Affinity Capture-MS Homo sapiens
26 RPA3 6119
Proximity Label-MS Homo sapiens
27 CHRNB4  
Affinity Capture-MS Homo sapiens
28 CNR2  
Affinity Capture-MS Homo sapiens
29 SLC22A15  
Affinity Capture-MS Homo sapiens
30 GDPD5 81544
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 TMC4  
Affinity Capture-MS Homo sapiens
32 ALDH3B1 221
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 UPK1A 11045
Affinity Capture-MS Homo sapiens
35 SLC22A4 6583
Affinity Capture-MS Homo sapiens
36 CXCR4 7852
Affinity Capture-MS Homo sapiens
37 CCDC47 57003
Affinity Capture-MS Homo sapiens
38 SEC61B 10952
Proximity Label-MS Homo sapiens
39 C17orf59 54785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 GFRA3 2676
Affinity Capture-MS Homo sapiens
41 AVPR2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SELT is involved
No pathways found





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