Gene description for CNPY3
Gene name canopy FGF signaling regulator 3
Gene symbol CNPY3
Other names/aliases CAG4A
ERDA5
PRAT4A
TNRC5
Species Homo sapiens
 Database cross references - CNPY3
ExoCarta ExoCarta_10695
Vesiclepedia VP_10695
Entrez Gene 10695
HGNC 11968
MIM 610774
UniProt Q9BT09  
 CNPY3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CNPY3
Molecular Function
    signaling receptor binding GO:0005102 IBA
    protein binding GO:0005515 IPI
Biological Process
    innate immune response GO:0045087 IEA
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 TAS
 Experiment description of studies that identified CNPY3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CNPY3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 NYX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LRRTM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 COLGALT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TLR10  
Affinity Capture-MS Homo sapiens
6 RXFP1  
Affinity Capture-MS Homo sapiens
7 LRIG2  
Affinity Capture-MS Homo sapiens
8 SELT 51714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SLITRK4 139065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 NRROS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 LRRC17 10234
Affinity Capture-MS Homo sapiens
12 LINGO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SLURP1  
Affinity Capture-MS Homo sapiens
14 COL6A1 1291
Affinity Capture-MS Homo sapiens
15 DEFA1 1667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 LRRC32 2615
Affinity Capture-MS Homo sapiens
17 LRG1 116844
Affinity Capture-MS Homo sapiens
18 CANX 821
Affinity Capture-MS Homo sapiens
19 LRRC59 55379
Proximity Label-MS Homo sapiens
20 PDIA4 9601
Proximity Label-MS Homo sapiens
21 CALU 813
Proximity Label-MS Homo sapiens
22 CALR3  
Proximity Label-MS Homo sapiens
23 ARSA 410
Affinity Capture-MS Homo sapiens
24 B3GNT3 10331
Affinity Capture-MS Homo sapiens
25 SEPN1 57190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ECEL1  
Affinity Capture-MS Homo sapiens
27 TLR5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 EGFR 1956
Affinity Capture-MS Homo sapiens
29 IGFALS 3483
Affinity Capture-MS Homo sapiens
30 LRRC4C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 GAA 2548
Affinity Capture-MS Homo sapiens
32 TLR8  
Affinity Capture-MS Homo sapiens
33 SPSB2  
Affinity Capture-MS Homo sapiens
34 LGR5 8549
Affinity Capture-MS Homo sapiens
35 CLDN5 7122
Two-hybrid Homo sapiens
36 TLR1 7096
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ABHD12 26090
Affinity Capture-MS Homo sapiens
38 GCNT2 2651
Affinity Capture-MS Homo sapiens
39 DCN 1634
Affinity Capture-MS Homo sapiens
40 TLR9  
Affinity Capture-MS Homo sapiens
41 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
42 ANKRD49  
Affinity Capture-MS Homo sapiens
43 FAM209A 200232
Two-hybrid Homo sapiens
44 MUT 4594
Co-fractionation Homo sapiens
45 B3GALT4  
Affinity Capture-MS Homo sapiens
46 PLD3 23646
Affinity Capture-MS Homo sapiens
47 GP5 2814
Affinity Capture-MS Homo sapiens
48 BRICD5  
Affinity Capture-MS Homo sapiens
49 LRRTM3  
Affinity Capture-MS Homo sapiens
50 TCEB2 6923
Affinity Capture-MS Homo sapiens
51 LRIG1 26018
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 OGN 4969
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 UGT1A7 54577
Affinity Capture-MS Homo sapiens
54 LRRTM1 347730
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 KCNJ6  
Two-hybrid Homo sapiens
56 IDS  
Affinity Capture-MS Homo sapiens
57 CREB3  
Two-hybrid Homo sapiens
58 SCRIB 23513
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 AMIGO1  
Affinity Capture-MS Homo sapiens
60 PLA1A  
Affinity Capture-MS Homo sapiens
61 COLGALT1 79709
Affinity Capture-MS Homo sapiens
62 LINGO1 84894
Affinity Capture-MS Homo sapiens
63 GOLM1 51280
Two-hybrid Homo sapiens
64 ST8SIA5  
Affinity Capture-MS Homo sapiens
65 ISLR 3671
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 VASN 114990
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 LRRC40 55631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 CHAD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 PXDN 7837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 SLITRK3  
Affinity Capture-MS Homo sapiens
71 LRRTM4  
Affinity Capture-MS Homo sapiens
72 SEC61B 10952
Proximity Label-MS Homo sapiens
73 COL12A1 1303
Affinity Capture-MS Homo sapiens
74 SLITRK6  
Affinity Capture-MS Homo sapiens
75 COL14A1 7373
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 LRRC1 55227
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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