Gene description for DCN
Gene name decorin
Gene symbol DCN
Other names/aliases CSCD
DSPG2
PG40
PGII
PGS2
SLRR1B
Species Homo sapiens
 Database cross references - DCN
ExoCarta ExoCarta_1634
Entrez Gene 1634
HGNC 2705
MIM 125255
UniProt P07585  
 DCN identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for DCN
Molecular Function
    extracellular matrix binding GO:0050840 IEA
    poly(A) RNA binding GO:0044822 IDA
    collagen binding GO:0005518 IEA
    protein N-terminus binding GO:0047485 IEA
    glycosaminoglycan binding GO:0005539 IEA
Biological Process
    skeletal muscle tissue development GO:0007519 IEA
    peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan GO:0019800 IEA
    positive regulation of autophagy GO:0010508 IDA
    placenta development GO:0001890 IEA
    wound healing GO:0042060 IEA
    chondroitin sulfate catabolic process GO:0030207 TAS
    response to mechanical stimulus GO:0009612 IEA
    aging GO:0007568 IEA
    extracellular matrix disassembly GO:0022617 TAS
    dermatan sulfate biosynthetic process GO:0030208 TAS
    response to lipopolysaccharide GO:0032496 IEA
    carbohydrate metabolic process GO:0005975 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    extracellular matrix organization GO:0030198 TAS
    kidney development GO:0001822 IEA
    organ morphogenesis GO:0009887 TAS
    chondroitin sulfate biosynthetic process GO:0030206 TAS
    chondroitin sulfate metabolic process GO:0030204 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    extracellular matrix GO:0031012 ISS
    collagen type VI trimer GO:0005589 IEA
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 TAS
    lysosomal lumen GO:0043202 TAS
    Golgi lumen GO:0005796 TAS
 Experiment description of studies that identified DCN in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for DCN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COL14A1 7373
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
2 THBS1 7057
Invivo Homo sapiens
Invitro Homo sapiens
3 C1QA 712
Reconstituted Complex Homo sapiens
4 SFTPD  
Reconstituted Complex Homo sapiens
5 TNF  
Reconstituted Complex Homo sapiens
6 PLA2G2A 5320
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
7 FBN1 2200
Invivo Homo sapiens
8 COL1A2 1278
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
9 COL6A1 1291
Reconstituted Complex Homo sapiens
10 AHSG 197
Invitro Homo sapiens
11 EGFR 1956
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
12 TGFB1 7040
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
13 FLNA  
Reconstituted Complex Homo sapiens
14 COL1A1 1277
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
15 SFTPA1  
Reconstituted Complex Homo sapiens
16 COL4A6  
Affinity Capture-MS Homo sapiens
17 COL2A1 1280
Affinity Capture-MS Homo sapiens
18 ELN  
Reconstituted Complex Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here