Gene description for PLA2G2A
Gene name phospholipase A2, group IIA (platelets, synovial fluid)
Gene symbol PLA2G2A
Other names/aliases MOM1
PLA2
PLA2B
PLA2L
PLA2S
PLAS1
sPLA2
Species Homo sapiens
 Database cross references - PLA2G2A
ExoCarta ExoCarta_5320
Entrez Gene 5320
HGNC 9031
MIM 172411
UniProt P14555  
 PLA2G2A identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for PLA2G2A
Molecular Function
    phospholipid binding GO:0005543 IDA
    calcium-dependent phospholipase A2 activity GO:0047498 TAS
    phospholipase A2 activity GO:0004623 TAS
    calcium ion binding GO:0005509 IEA
Biological Process
    low-density lipoprotein particle remodeling GO:0034374 TAS
    phosphatidic acid metabolic process GO:0046473 IDA
    positive regulation of macrophage derived foam cell differentiation GO:0010744 TAS
    negative regulation of epithelial cell proliferation GO:0050680 IEA
    positive regulation of inflammatory response GO:0050729 TAS
    small molecule metabolic process GO:0044281 TAS
    phosphatidylserine acyl-chain remodeling GO:0036150 TAS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    phosphatidic acid biosynthetic process GO:0006654 TAS
    defense response to Gram-positive bacterium GO:0050830 TAS
    phosphatidylglycerol acyl-chain remodeling GO:0036148 TAS
    phosphatidylinositol acyl-chain remodeling GO:0036149 TAS
    somatic stem cell maintenance GO:0035019 IEA
    phosphatidylcholine acyl-chain remodeling GO:0036151 TAS
    lipid catabolic process GO:0016042 IEA
    phospholipid metabolic process GO:0006644 TAS
    phosphatidylethanolamine acyl-chain remodeling GO:0036152 TAS
    glycerophospholipid biosynthetic process GO:0046474 TAS
Subcellular Localization
    mitochondrion GO:0005739 IEA
    extracellular space GO:0005615 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    extracellular region GO:0005576 TAS
    endoplasmic reticulum GO:0005783 IDA
    extracellular exosome GO:0070062 IDA
    secretory granule GO:0030141 IEA
 Experiment description of studies that identified PLA2G2A in exosomes
1
Experiment ID 234
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 234
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for PLA2G2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VCAN 1462
Invitro Homo sapiens
2 DCN 1634
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
3 PLA2G1B  
Reconstituted Complex Homo sapiens
4 PLA2G2A 5320
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
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