Gene description for ALOX12
Gene name	arachidonate 12-lipoxygenase
Gene symbol	ALOX12
Other names/aliases	12-LOX 12S-LOX LOG12
Species	Homo sapiens
Database cross references - ALOX12
ExoCarta	ExoCarta_239
Entrez Gene	239
HGNC	429
MIM	152391
UniProt	P18054
ALOX12 identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113
Urine	19056867

Gene ontology annotations for ALOX12

Molecular Function     hepoxilin-epoxide hydrolase activity GO:0047977 ISS     hepoxilin A3 synthase activity GO:0051120 TAS     linoleate 13S-lipoxygenase activity GO:0016165 IDA     iron ion binding GO:0005506 IEA     oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 TAS     protein binding GO:0005515 IPI     arachidonate 12-lipoxygenase activity GO:0004052 TAS Biological Process     lipoxin A4 biosynthetic process GO:2001303 IDA     reactive oxygen species metabolic process GO:0072593 NAS     positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 IEA     lipoxin B4 biosynthetic process GO:2001306 IDA     lipoxin metabolic process GO:2001300 TAS     aging GO:0007568 IEA     positive regulation of vasodilation GO:0045909 IEA     positive regulation of endothelial cell migration GO:0010595 IEA     small molecule metabolic process GO:0044281 TAS     fatty acid oxidation GO:0019395 IMP     cellular response to lipid GO:0071396 IEA     negative regulation of muscle cell apoptotic process GO:0010656 IMP     positive regulation of endothelial cell differentiation GO:0045603 IEA     leukotriene A4 metabolic process GO:1901751 IDA     superoxide anion generation GO:0042554 NAS     arachidonic acid metabolic process GO:0019369 TAS     establishment of skin barrier GO:0061436 ISS     positive regulation of cell proliferation GO:0008284 ISS     positive regulation of cell migration GO:0030335 IMP     positive regulation of cell growth GO:0030307 IMP     lipoxygenase pathway GO:0019372 TAS     positive regulation of gene expression GO:0010628 IEA     hepoxilin metabolic process GO:0051121 TAS     positive regulation of cell adhesion GO:0045785 IMP     positive regulation of angiogenesis GO:0045766 IMP     movement of cell or subcellular component GO:0006928 IMP     hepoxilin biosynthetic process GO:0051122 ISS     linoleic acid metabolic process GO:0043651 IDA     positive regulation of mitochondrial depolarization GO:0051901 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 IEA     negative regulation of platelet aggregation GO:0090331 ISS     negative regulation of apoptotic process GO:0043066 ISS Subcellular Localization     cytoplasm GO:0005737 IDA     extracellular exosome GO:0070062 IDA     membrane GO:0016020 IDA     cytosol GO:0005829 TAS     sarcolemma GO:0042383 IDA