Gene description for TGFB2
Gene name	transforming growth factor, beta 2
Gene symbol	TGFB2
Other names/aliases	LDS4 TGF-beta2
Species	Homo sapiens
Database cross references - TGFB2
ExoCarta	ExoCarta_7042
Entrez Gene	7042
HGNC	11768
MIM	190220
UniProt	P61812
TGFB2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for TGFB2

Molecular Function     type III transforming growth factor beta receptor binding GO:0034714 IPI     beta-amyloid binding GO:0001540 IDA     protein homodimerization activity GO:0042803 IDA     receptor binding GO:0005102 IMP     receptor signaling protein serine/threonine kinase activity GO:0004702 IDA     growth factor activity GO:0008083 IEA     protein heterodimerization activity GO:0046982 TAS     transforming growth factor beta receptor binding GO:0005160 IDA     cytokine activity GO:0005125 TAS     protein binding GO:0005515 IPI     type II transforming growth factor beta receptor binding GO:0005114 IPI Biological Process     generation of neurons GO:0048699 TAS     cartilage condensation GO:0001502 IEA     negative regulation of macrophage cytokine production GO:0010936 IDA     salivary gland morphogenesis GO:0007435 IEP     heart valve morphogenesis GO:0003179 IEA     heart morphogenesis GO:0003007 IDA     positive regulation of neuron apoptotic process GO:0043525 IDA     positive regulation of epithelial to mesenchymal transition GO:0010718 IDA     extrinsic apoptotic signaling pathway GO:0097191 IDA     extracellular matrix organization GO:0030198 TAS     positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IEA     negative regulation of immune response GO:0050777 TAS     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IDA     cell growth GO:0016049 IEA     cell migration GO:0016477 IDA     pathway-restricted SMAD protein phosphorylation GO:0060389 IDA     positive regulation of protein secretion GO:0050714 IDA     positive regulation of activation-induced cell death of T cells GO:0070237 IEA     SMAD protein signal transduction GO:0060395 IBA     odontogenesis GO:0042476 NAS     cardioblast differentiation GO:0010002 IDA     hair follicle morphogenesis GO:0031069 ISS     epithelial to mesenchymal transition GO:0001837 TAS     SMAD protein import into nucleus GO:0007184 IDA     response to hypoxia GO:0001666 IMP     face morphogenesis GO:0060325 IEA     positive regulation of cell growth GO:0030307 IDA     cardiac epithelial to mesenchymal transition GO:0060317 IDA     positive regulation of epithelial cell migration GO:0010634 IDA     cell development GO:0048468 IBA     platelet degranulation GO:0002576 TAS     positive regulation of catagen GO:0051795 IDA     negative regulation of epithelial cell proliferation GO:0050680 IMP     negative regulation of cell growth GO:0030308 IDA     positive regulation of stress-activated MAPK cascade GO:0032874 IDA     protein phosphorylation GO:0006468 IDA     blood vessel remodeling GO:0001974 IEA     eye development GO:0001654 IDA     embryo development GO:0009790 TAS     glial cell migration GO:0008347 IDA     collagen fibril organization GO:0030199 IDA     heart development GO:0007507 IDA     hair follicle development GO:0001942 ISS     cell proliferation GO:0008283 TAS     response to drug GO:0042493 IDA     positive regulation of immune response GO:0050778 ISS     activation of protein kinase activity GO:0032147 IDA     transforming growth factor beta receptor signaling pathway GO:0007179 IDA     blood coagulation GO:0007596 TAS     neuron fate commitment GO:0048663 IEA     somatic stem cell division GO:0048103 ISS     neutrophil chemotaxis GO:0030593 TAS     hemopoiesis GO:0030097 ISS     catagen GO:0042637 IDA     regulation of transforming growth factor beta2 production GO:0032909 IMP     cell cycle arrest GO:0007050 IDA     cell death GO:0008219 IDA     angiogenesis GO:0001525 TAS     cardiac muscle cell proliferation GO:0060038 IDA     positive regulation of gene expression GO:0010628 IEA     positive regulation of integrin biosynthetic process GO:0045726 IDA     positive regulation of cell adhesion mediated by integrin GO:0033630 IDA     negative regulation of cartilage development GO:0061037 IEA     cell-cell junction organization GO:0045216 IDA     wound healing GO:0042060 ISS     positive regulation of cell proliferation GO:0008284 IDA     embryonic digestive tract development GO:0048566 IEP     negative regulation of alkaline phosphatase activity GO:0010693 IDA     positive regulation of cell cycle GO:0045787 ISS     positive regulation of cardioblast differentiation GO:0051891 IDA     response to wounding GO:0009611 IEP     regulation of extracellular matrix organization GO:1903053 IEA     uterine wall breakdown GO:0042704 TAS     axon guidance GO:0007411 IEA     cell-cell signaling GO:0007267 TAS     negative regulation of cell proliferation GO:0008285 IDA     response to progesterone GO:0032570 IDA     platelet activation GO:0030168 TAS     positive regulation of ossification GO:0045778 IEP     regulation of complement-dependent cytotoxicity GO:1903659 IMP     positive regulation of cell division GO:0051781 IEA     neuron development GO:0048666 ISS     cell morphogenesis GO:0000902 IDA     dopamine biosynthetic process GO:0042416 ISS     positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IBA     positive regulation of heart contraction GO:0045823 IDA     signal transduction by protein phosphorylation GO:0023014 IDA Subcellular Localization     extracellular matrix GO:0031012 IDA     axon GO:0030424 ISS     extracellular space GO:0005615 IDA     endosome GO:0005768 IEA     neuronal cell body GO:0043025 ISS     platelet alpha granule lumen GO:0031093 TAS     extracellular region GO:0005576 TAS