Gene description for TGFBR2
Gene name	transforming growth factor, beta receptor II (70/80kDa)
Gene symbol	TGFBR2
Other names/aliases	AAT3 FAA3 LDS1B LDS2 LDS2B MFS2 RIIC TAAD2 TGFR-2 TGFbeta-RII
Species	Homo sapiens
Database cross references - TGFBR2
ExoCarta	ExoCarta_7048
Entrez Gene	7048
HGNC	11773
MIM	190182
UniProt	P37173
TGFBR2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for TGFBR2

Molecular Function     metal ion binding GO:0046872 IEA     transforming growth factor beta receptor activity, type II GO:0005026 IEA     protein binding GO:0005515 IPI     SMAD binding GO:0046332 IDA     ATP binding GO:0005524 IEA     transforming growth factor beta binding GO:0050431 IPI     type III transforming growth factor beta receptor binding GO:0034714 IDA     transforming growth factor beta-activated receptor activity GO:0005024 IMP     receptor signaling protein serine/threonine kinase activity GO:0004702 IEA     glycosaminoglycan binding GO:0005539 IDA     type I transforming growth factor beta receptor binding GO:0034713 IPI     transmembrane receptor protein serine/threonine kinase activity GO:0004675 IDA     mitogen-activated protein kinase kinase kinase binding GO:0031435 IEA Biological Process     embryonic cranial skeleton morphogenesis GO:0048701 ISS     lens fiber cell apoptotic process GO:1990086 IEA     aging GO:0007568 IEA     myeloid dendritic cell differentiation GO:0043011 ISS     smoothened signaling pathway GO:0007224 IEA     protein phosphorylation GO:0006468 IDA     response to glucose GO:0009749 IEA     positive regulation of B cell tolerance induction GO:0002663 ISS     organ regeneration GO:0031100 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 IEA     gastrulation GO:0007369 IEA     response to mechanical stimulus GO:0009612 IEA     vasculogenesis GO:0001570 ISS     positive regulation of T cell tolerance induction GO:0002666 ISS     positive regulation of NK T cell differentiation GO:0051138 ISS     wound healing GO:0042060 IEA     response to estrogen GO:0043627 IEA     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 TAS     common-partner SMAD protein phosphorylation GO:0007182 IEA     negative regulation of cardiac muscle cell proliferation GO:0060044 IEA     palate development GO:0060021 ISS     blood vessel development GO:0001568 TAS     trachea formation GO:0060440 IEA     positive regulation of angiogenesis GO:0045766 IEA     peptidyl-threonine phosphorylation GO:0018107 IDA     positive regulation of skeletal muscle tissue regeneration GO:0043415 IEA     positive regulation of epithelial cell migration GO:0010634 IEA     response to cholesterol GO:0070723 IDA     apoptotic process GO:0006915 IDA     activation of protein kinase activity GO:0032147 ISS     regulation of cell proliferation GO:0042127 ISS     digestive tract development GO:0048565 IEA     response to drug GO:0042493 IDA     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     positive regulation of tolerance induction to self antigen GO:0002651 ISS     pathway-restricted SMAD protein phosphorylation GO:0060389 IDA     growth plate cartilage chondrocyte growth GO:0003430 IEA     in utero embryonic development GO:0001701 IEA     lung lobe morphogenesis GO:0060463 IEA     lens development in camera-type eye GO:0002088 IEA     embryonic hemopoiesis GO:0035162 ISS     positive regulation of mesenchymal cell proliferation GO:0002053 ISS     patterning of blood vessels GO:0001569 ISS     positive regulation of cell proliferation GO:0008284 TAS     bronchus morphogenesis GO:0060434 IEA     receptor-mediated endocytosis GO:0006898 IEA     embryo implantation GO:0007566 IEA     mammary gland morphogenesis GO:0060443 IEA     heart development GO:0007507 ISS     regulation of gene expression GO:0010468 IEA     positive regulation of reactive oxygen species metabolic process GO:2000379 IMP     peptidyl-serine phosphorylation GO:0018105 IDA     response to nutrient GO:0007584 IEA     brain development GO:0007420 ISS     signal transduction by protein phosphorylation GO:0023014 IEA Subcellular Localization     external side of plasma membrane GO:0009897 IDA     caveola GO:0005901 IDA     receptor complex GO:0043235 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 TAS     integral component of membrane GO:0016021 IDA     transforming growth factor beta receptor homodimeric complex GO:0070022 IC