Gene description for TGFBR2
Gene name transforming growth factor, beta receptor II (70/80kDa)
Gene symbol TGFBR2
Other names/aliases AAT3
FAA3
LDS1B
LDS2
LDS2B
MFS2
RIIC
TAAD2
TGFR-2
TGFbeta-RII
Species Homo sapiens
 Database cross references - TGFBR2
ExoCarta ExoCarta_7048
Vesiclepedia VP_7048
Entrez Gene 7048
HGNC 11773
MIM 190182
UniProt P37173  
 TGFBR2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TGFBR2
Molecular Function
    protein serine/threonine kinase activity GO:0004674 TAS
    transmembrane receptor protein serine/threonine kinase activity GO:0004675 IDA
    transforming growth factor beta receptor activity GO:0005024 IBA
    transforming growth factor beta receptor activity GO:0005024 IC
    transforming growth factor beta receptor activity GO:0005024 IDA
    transforming growth factor beta receptor activity GO:0005024 IMP
    transforming growth factor beta receptor activity, type I GO:0005025 IEA
    transforming growth factor beta receptor activity, type II GO:0005026 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    glycosaminoglycan binding GO:0005539 IDA
    activin receptor activity, type I GO:0016361 IBA
    activin receptor activity, type I GO:0016361 IEA
    activin receptor activity, type II GO:0016362 IEA
    kinase activator activity GO:0019209 IEA
    type I transforming growth factor beta receptor binding GO:0034713 IBA
    type I transforming growth factor beta receptor binding GO:0034713 IDA
    type I transforming growth factor beta receptor binding GO:0034713 IPI
    type III transforming growth factor beta receptor binding GO:0034714 IDA
    SMAD binding GO:0046332 IDA
    metal ion binding GO:0046872 IEA
    activin binding GO:0048185 IBA
    transforming growth factor beta binding GO:0050431 IDA
    transforming growth factor beta binding GO:0050431 IPI
    transforming growth factor beta binding GO:0050431 IPI
    molecular adaptor activity GO:0060090 EXP
    transforming growth factor beta receptor activity, type III GO:0070123 IEA
    BMP receptor activity GO:0098821 IEA
Biological Process
    blood vessel development GO:0001568 TAS
    branching involved in blood vessel morphogenesis GO:0001569 ISS
    vasculogenesis GO:0001570 ISS
    in utero embryonic development GO:0001701 IEA
    epithelial to mesenchymal transition GO:0001837 IMP
    heart looping GO:0001947 ISS
    positive regulation of mesenchymal cell proliferation GO:0002053 ISS
    lens development in camera-type eye GO:0002088 IEA
    positive regulation of tolerance induction to self antigen GO:0002651 ISS
    positive regulation of B cell tolerance induction GO:0002663 ISS
    positive regulation of T cell tolerance induction GO:0002666 ISS
    outflow tract septum morphogenesis GO:0003148 ISS
    membranous septum morphogenesis GO:0003149 ISS
    outflow tract morphogenesis GO:0003151 ISS
    aortic valve morphogenesis GO:0003180 IMP
    atrioventricular valve morphogenesis GO:0003181 ISS
    tricuspid valve morphogenesis GO:0003186 ISS
    cardiac left ventricle morphogenesis GO:0003214 ISS
    endocardial cushion fusion GO:0003274 ISS
    growth plate cartilage chondrocyte growth GO:0003430 IEA
    apoptotic process GO:0006915 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 IC
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 ISS
    Notch signaling pathway GO:0007219 IEA
    smoothened signaling pathway GO:0007224 IEA
    gastrulation GO:0007369 IEA
    nervous system development GO:0007399 IBA
    brain development GO:0007420 ISS
    heart development GO:0007507 IBA
    heart development GO:0007507 ISS
    positive regulation of cell population proliferation GO:0008284 TAS
    response to xenobiotic stimulus GO:0009410 IDA
    regulation of gene expression GO:0010468 IEA
    positive regulation of epithelial cell migration GO:0010634 IEA
    positive regulation of epithelial to mesenchymal transition GO:0010718 IDA
    BMP signaling pathway GO:0030509 IEA
    activin receptor signaling pathway GO:0032924 IBA
    activin receptor signaling pathway GO:0032924 IEA
    embryonic hemopoiesis GO:0035162 ISS
    aorta morphogenesis GO:0035909 IMP
    regulation of cell population proliferation GO:0042127 ISS
    myeloid dendritic cell differentiation GO:0043011 ISS
    positive regulation of angiogenesis GO:0045766 IEA
    embryonic cranial skeleton morphogenesis GO:0048701 ISS
    artery morphogenesis GO:0048844 IMP
    positive regulation of NK T cell differentiation GO:0051138 ISS
    roof of mouth development GO:0060021 IMP
    positive regulation of SMAD protein signal transduction GO:0060391 IDA
    positive regulation of SMAD protein signal transduction GO:0060391 IMP
    SMAD protein signal transduction GO:0060395 IEA
    ventricular septum morphogenesis GO:0060412 ISS
    bronchus morphogenesis GO:0060434 IEA
    trachea formation GO:0060440 IEA
    mammary gland morphogenesis GO:0060443 IEA
    lung lobe morphogenesis GO:0060463 IEA
    Langerhans cell differentiation GO:0061520 IEA
    secondary palate development GO:0062009 ISS
    response to cholesterol GO:0070723 IDA
    cellular response to growth factor stimulus GO:0071363 IBA
    regulation of stem cell proliferation GO:0072091 IEA
    positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 ISS
    cell proliferation involved in endocardial cushion morphogenesis GO:1905315 ISS
    superior endocardial cushion morphogenesis GO:1905316 ISS
    inferior endocardial cushion morphogenesis GO:1905317 ISS
    lens fiber cell apoptotic process GO:1990086 IEA
    miRNA transport GO:1990428 ISS
    positive regulation of reactive oxygen species metabolic process GO:2000379 IMP
    positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 IDA
    regulation of stem cell differentiation GO:2000736 IMP
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    caveola GO:0005901 IDA
    external side of plasma membrane GO:0009897 IDA
    membrane GO:0016020 IDA
    receptor complex GO:0043235 IDA
    membrane raft GO:0045121 IDA
    activin receptor complex GO:0048179 IBA
    transforming growth factor beta ligand-receptor complex GO:0070021 IPI
    transforming growth factor beta ligand-receptor complex GO:0070021 ISS
 Experiment description of studies that identified TGFBR2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
8
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TGFBR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 CALHM2 51063
Affinity Capture-MS Homo sapiens
3 PTPRF 5792
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 AXL 558
Affinity Capture-MS Homo sapiens
5 ARHGAP1 392
Affinity Capture-MS Homo sapiens
6 OSMR 9180
Affinity Capture-MS Homo sapiens
7 AP2B1 163
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
8 RCVRN  
Two-hybrid Homo sapiens
9 OCLN 100506658
Affinity Capture-Western Homo sapiens
10 CCNB2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
11 TRAF4 9618
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 CTDNEP1 23399
Affinity Capture-MS Homo sapiens
13 FMN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TGFB3 7043
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 SNX6 58533
Affinity Capture-Western Homo sapiens
16 FBXO34  
Affinity Capture-Western Homo sapiens
17 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
18 LRP10 26020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MYADM 91663
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TGFBR1 7046
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
21 CD320 51293
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 IFITM3 10410
Affinity Capture-MS Homo sapiens
23 SLC20A1 6574
Affinity Capture-MS Homo sapiens
24 Atm  
Affinity Capture-Western Mus musculus
25 TGFB1 7040
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
26 FAM171A2 284069
Affinity Capture-MS Homo sapiens
27 YES1 7525
Affinity Capture-MS Homo sapiens
28 IQGAP1 8826
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 FGFR4 2264
Affinity Capture-MS Homo sapiens
30 ACVR2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MFAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 USP33  
Affinity Capture-MS Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
33 TERT  
Two-hybrid Homo sapiens
34 SLC25A31 83447
Affinity Capture-MS Homo sapiens
35 USP2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
36 RAB6B 51560
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PKN2 5586
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ERBB2 2064
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 FGFR1 2260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 ACVR1 90
Two-hybrid Homo sapiens
41 PLEKHH3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CBL 867
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
43 PAK1 5058
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
44 NDFIP1 80762
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 RAB5A 5868
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
46 MARCH7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 Ubc  
Affinity Capture-Western Rattus norvegicus
48 CLU 1191
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
49 PSMD14 10213
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
50 PPP1R16B  
Affinity Capture-Western Homo sapiens
51 CCNB1 891
Reconstituted Complex Homo sapiens
52 ACVR1B 91
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 TYK2 7297
Affinity Capture-MS Homo sapiens
54 GOPC 57120
Two-hybrid Homo sapiens
55 ARHGEF6 9459
Affinity Capture-Western Homo sapiens
56 PIK3R1 5295
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 TGFB2 7042
Affinity Capture-Western Homo sapiens
58 TGFBR3 7049
Affinity Capture-Western Homo sapiens
59 TNFRSF10A 8797
Affinity Capture-MS Homo sapiens
60 PIK3CB 5291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 RAB6A 5870
Affinity Capture-MS Homo sapiens
62 SPSB1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 TRAF6 7189
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
64 MARCH1  
Affinity Capture-MS Homo sapiens
65 KCNK18  
Affinity Capture-Western Homo sapiens
66 CTNNB1 1499
Affinity Capture-Western Homo sapiens
67 PDGFRA 5156
Two-hybrid Homo sapiens
68 ACVR2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 DIP2A 23181
Affinity Capture-MS Homo sapiens
70 RASSF1  
Affinity Capture-Western Homo sapiens
71 Hsp90aa1 299331
Affinity Capture-Western Rattus norvegicus
72 NRP2 8828
Affinity Capture-Western Homo sapiens
73 MAP3K7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
74 CDC42 998
Affinity Capture-Western Homo sapiens
75 STRAP 11171
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
76 UMPS 7372
Affinity Capture-MS Homo sapiens
77 JAK1 3716
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 RELT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 CXorf58  
Affinity Capture-MS Homo sapiens
80 SBF1 6305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 WDR44 54521
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 TDGF1  
Reconstituted Complex Homo sapiens
83 DENND6A 201627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 TMEM200A 114801
Affinity Capture-MS Homo sapiens
85 NRP1 8829
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
86 DAB2 1601
Affinity Capture-Western Homo sapiens
87 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
88 RHBDF2 79651
Affinity Capture-MS Homo sapiens
89 PTPRD 5789
Affinity Capture-MS Homo sapiens
90 EHD4 30844
Affinity Capture-MS Homo sapiens
91 LSR 51599
Affinity Capture-MS Homo sapiens
92 ENG 2022
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
93 SMURF1 57154
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 SQSTM1 8878
Affinity Capture-Western Homo sapiens
95 OXSR1 9943
Affinity Capture-Western Homo sapiens
96 CDC6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 BMPR1A 657
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 HSP90AA1 3320
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
99 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
100 TSC22D1 8848
Affinity Capture-Western Homo sapiens
101 PTPRS 5802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 DDR1 780
Affinity Capture-MS Homo sapiens
103 RAB7A 7879
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
104 RAB11A 8766
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
105 PIK3R2 5296
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
107 SMURF2 64750
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
108 CAV1 857
Affinity Capture-Western Homo sapiens
109 PKN3 29941
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 MYOF 26509
Affinity Capture-MS Homo sapiens
111 PIK3R3 8503
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 HTR1A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which TGFBR2 is involved
PathwayEvidenceSource
Deubiquitination IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downregulation of TGF-beta receptor signaling IEA Reactome
Downregulation of TGF-beta receptor signaling TAS Reactome
Loss of Function of SMAD2/3 in Cancer TAS Reactome
Loss of Function of TGFBR1 in Cancer TAS Reactome
Loss of Function of TGFBR2 in Cancer TAS Reactome
Metabolism of proteins IEA Reactome
Post-translational protein modification IEA Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by TGF-beta Receptor Complex TAS Reactome
Signaling by TGF-beta Receptor Complex IEA Reactome
Signaling by TGF-beta Receptor Complex in Cancer TAS Reactome
Signaling by TGFB family members TAS Reactome
Signaling by TGFB family members IEA Reactome
Signaling by TGFBR3 TAS Reactome
SMAD2/3 Phosphorylation Motif Mutants in Cancer TAS Reactome
TGF-beta receptor signaling activates SMADs TAS Reactome
TGF-beta receptor signaling activates SMADs IEA Reactome
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TAS Reactome
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IEA Reactome
TGFBR1 KD Mutants in Cancer TAS Reactome
TGFBR1 LBD Mutants in Cancer TAS Reactome
TGFBR2 Kinase Domain Mutants in Cancer TAS Reactome
TGFBR2 MSI Frameshift Mutants in Cancer TAS Reactome
TGFBR3 regulates TGF-beta signaling TAS Reactome
UCH proteinases IEA Reactome





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