Gene description for DENND6A
Gene name DENN/MADD domain containing 6A
Gene symbol DENND6A
Other names/aliases AFI1A
FAM116A
Species Homo sapiens
 Database cross references - DENND6A
ExoCarta ExoCarta_201627
Entrez Gene 201627
HGNC 26635
UniProt Q8IWF6  
 DENND6A identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for DENND6A
Molecular Function
    Rab guanyl-nucleotide exchange factor activity GO:0017112 IDA
Biological Process
    positive regulation of cell-cell adhesion mediated by cadherin GO:2000049 IDA
    positive regulation of GTPase activity GO:0043547 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    recycling endosome GO:0055037 IDA
 Experiment description of studies that identified DENND6A in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DENND6A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DENND6A is involved
No pathways found





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