Gene description for EFNB3
Gene name ephrin-B3
Gene symbol EFNB3
Other names/aliases EFL6
EPLG8
LERK8
Species Homo sapiens
 Database cross references - EFNB3
ExoCarta ExoCarta_1949
Vesiclepedia VP_1949
Entrez Gene 1949
HGNC 3228
MIM 602297
UniProt Q15768  
 EFNB3 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for EFNB3
Molecular Function
    ephrin receptor binding GO:0046875 IDA
    transmembrane-ephrin receptor activity GO:0005005 TAS
Biological Process
    adult walking behavior GO:0007628 IEA
    axon choice point recognition GO:0016198 IEA
    axon guidance GO:0007411 TAS
    ephrin receptor signaling pathway GO:0048013 TAS
    cell-cell signaling GO:0007267 TAS
    viral process GO:0016032 IEA
    nervous system development GO:0007399 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified EFNB3 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for EFNB3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EPHA4 2043
Reconstituted Complex Homo sapiens
2 GRIP2 80852
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
3 EPHB3 2049
Reconstituted Complex Homo sapiens
4 RHBDL2  
Biochemical Activity Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here