Gene description for CDYL
Gene name chromodomain protein, Y-like
Gene symbol CDYL
Other names/aliases CDYL1
Species Homo sapiens
 Database cross references - CDYL
ExoCarta ExoCarta_9425
Entrez Gene 9425
HGNC 1811
MIM 603778
UniProt Q9Y232  
 CDYL identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CDYL
Molecular Function
    methylated histone binding GO:0035064 IDA
    histone acetyltransferase activity GO:0004402 IEA
    protein binding GO:0005515 IPI
    transcription corepressor activity GO:0003714 IMP
Biological Process
    spermatogenesis GO:0007283 TAS
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription, DNA-templated GO:0006351 IEA
    histone acetylation GO:0016573 IEA
    negative regulation of nucleic acid-templated transcription GO:1903507 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified CDYL in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CDYL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HDAC2 3066
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which CDYL is involved
No pathways found

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