Gene description for REST
Gene name	RE1-silencing transcription factor
Gene symbol	REST
Other names/aliases	NRSF XBR
Species	Homo sapiens
Database cross references - REST
ExoCarta	ExoCarta_5978
Vesiclepedia	VP_5978
Entrez Gene	5978
HGNC	9966
MIM	600571
UniProt	Q13127
REST identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for REST

Molecular Function     core promoter binding GO:0001047 IDA     RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IDA     core promoter sequence-specific DNA binding GO:0001046 IDA     sequence-specific DNA binding transcription factor activity GO:0003700 IDA     chromatin binding GO:0003682 ISS     transcription factor binding GO:0008134 IPI     outward rectifier potassium channel activity GO:0015271 IMP     protein binding GO:0005515 IPI     transcription regulatory region DNA binding GO:0044212 IDA     metal ion binding GO:0046872 IEA Biological Process     negative regulation of insulin secretion GO:0046676 IMP     transcription from RNA polymerase II promoter GO:0006366 IEA     negative regulation of transcription, DNA-templated GO:0045892 NAS     negative regulation of neurogenesis GO:0050768 ISS     positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 IMP     regulation of transcription, DNA-templated GO:0006355 NAS     negative regulation of amniotic stem cell differentiation GO:2000798 IMP     negative regulation of mesenchymal stem cell differentiation GO:2000740 IMP     cellular response to drug GO:0035690 IMP     hematopoietic progenitor cell differentiation GO:0002244 IEA     negative regulation of gene expression GO:0010629 IMP     positive regulation of transcription, DNA-templated GO:0045893 IDA     cellular response to glucocorticoid stimulus GO:0071385 IDA     chromatin organization GO:0006325 TAS     negative regulation of aldosterone biosynthetic process GO:0032348 IMP     positive regulation of apoptotic process GO:0043065 IMP     negative regulation of dense core granule biogenesis GO:2000706 ISS     cardiac muscle cell myoblast differentiation GO:0060379 ISS     potassium ion transmembrane transport GO:0071805 IMP     negative regulation by host of viral transcription GO:0043922 IDA     negative regulation of cortisol biosynthetic process GO:2000065 IMP     histone H4 deacetylation GO:0070933 IDA     negative regulation of cell proliferation GO:0008285 IMP     negative regulation of neuron differentiation GO:0045665 IMP     negative regulation of transcription from RNA polymerase II promoter GO:0000122 TAS     cellular response to electrical stimulus GO:0071257 IMP     negative regulation of calcium ion-dependent exocytosis GO:0045955 ISS Subcellular Localization     cytosol GO:0005829 IEA     nucleoplasm GO:0005654 TAS     transcriptional repressor complex GO:0017053 IDA     nucleus GO:0005634 NAS