Gene description for MAPK1
Gene name	mitogen-activated protein kinase 1
Gene symbol	MAPK1
Other names/aliases	ERK ERK-2 ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk p42-MAPK
Species	Homo sapiens
Database cross references - MAPK1
ExoCarta	ExoCarta_5594
Entrez Gene	5594
HGNC	6871
MIM	176948
UniProt	P28482
MAPK1 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Hepatocytes	26054723
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Platelets	25332113
Platelets	25332113
Platelets	25332113
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for MAPK1

Molecular Function     mitogen-activated protein kinase kinase kinase binding GO:0031435 IEA     phosphotyrosine binding GO:0001784 IEA     protein serine/threonine kinase activity GO:0004674 IDA     protein binding GO:0005515 IPI     RNA polymerase II carboxy-terminal domain kinase activity GO:0008353 ISS     DNA binding GO:0003677 IEA     phosphatase binding GO:0019902 IPI     ATP binding GO:0005524 IEA     MAP kinase activity GO:0004707 IEA     transcription factor binding GO:0008134 IEA Biological Process     regulation of early endosome to late endosome transport GO:2000641 TAS     T cell receptor signaling pathway GO:0050852 IEA     regulation of cytoskeleton organization GO:0051493 TAS     positive regulation of translation GO:0045727 IEA     cellular response to DNA damage stimulus GO:0006974 IEA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     activation of MAPK activity GO:0000187 TAS     signal transduction GO:0007165 TAS     ERBB signaling pathway GO:0038127 IDA     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     regulation of Golgi inheritance GO:0090170 TAS     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     innate immune response GO:0045087 TAS     synaptic transmission GO:0007268 TAS     toll-like receptor 5 signaling pathway GO:0034146 TAS     toll-like receptor 9 signaling pathway GO:0034162 TAS     activation of MAPKK activity GO:0000186 TAS     caveolin-mediated endocytosis GO:0072584 TAS     peptidyl-serine phosphorylation GO:0018105 IDA     insulin receptor signaling pathway GO:0008286 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     blood coagulation GO:0007596 TAS     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     MAPK cascade GO:0000165 TAS     toll-like receptor 10 signaling pathway GO:0034166 TAS     organ morphogenesis GO:0009887 IEA     cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 IEA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     ERK1 and ERK2 cascade GO:0070371 TAS     response to toxic substance GO:0009636 IEA     sensory perception of pain GO:0019233 IEA     Ras protein signal transduction GO:0007265 TAS     viral process GO:0016032 IEA     protein phosphorylation GO:0006468 IDA     cellular response to heat GO:0034605 TAS     mammary gland epithelial cell proliferation GO:0033598 IEA     cytosine metabolic process GO:0019858 IEA     stress-activated MAPK cascade GO:0051403 TAS     response to stress GO:0006950 TAS     MAPK import into nucleus GO:0000189 IEA     toll-like receptor 3 signaling pathway GO:0034138 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS     axon guidance GO:0007411 TAS     apoptotic process GO:0006915 IEA     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     regulation of cellular response to heat GO:1900034 TAS     lipopolysaccharide-mediated signaling pathway GO:0031663 IEA     peptidyl-threonine phosphorylation GO:0018107 ISS     transcription, DNA-templated GO:0006351 IEA     negative regulation of cell differentiation GO:0045596 IEA     response to exogenous dsRNA GO:0043330 IEA     toll-like receptor signaling pathway GO:0002224 TAS     regulation of protein stability GO:0031647 ISS     small GTPase mediated signal transduction GO:0007264 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     labyrinthine layer blood vessel development GO:0060716 IEA     regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS     positive regulation of cell proliferation GO:0008284 IEA     chemotaxis GO:0006935 TAS     B cell receptor signaling pathway GO:0050853 IEA     positive regulation of cell migration GO:0030335 IEA     response to epidermal growth factor GO:0070849 IDA     positive regulation of peptidyl-threonine phosphorylation GO:0010800 IDA     regulation of stress-activated MAPK cascade GO:0032872 TAS     response to estrogen GO:0043627 IEA     cell cycle GO:0007049 IEA     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     toll-like receptor 2 signaling pathway GO:0034134 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS     platelet activation GO:0030168 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     positive regulation of transcription, DNA-templated GO:0045893 IEA Subcellular Localization     cytosol GO:0005829 TAS     cytoplasm GO:0005737 ISS     early endosome GO:0005769 TAS     Golgi apparatus GO:0005794 TAS     cytoskeleton GO:0005856 TAS     late endosome GO:0005770 TAS     microtubule cytoskeleton GO:0015630 IDA     nucleoplasm GO:0005654 TAS     caveola GO:0005901 TAS     pseudopodium GO:0031143 IEA     mitochondrion GO:0005739 TAS     protein complex GO:0043234 IEA     perikaryon GO:0043204 IEA     nucleus GO:0005634 TAS     dendrite cytoplasm GO:0032839 IEA     microtubule organizing center GO:0005815 IEA     focal adhesion GO:0005925 TAS     axon GO:0030424 IEA     mitotic spindle GO:0072686 ISS     extracellular exosome GO:0070062 IDA