Gene description for MAPK1
Gene name mitogen-activated protein kinase 1
Gene symbol MAPK1
Other names/aliases ERK
ERK-2
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
p42-MAPK
Species Homo sapiens
 Database cross references - MAPK1
ExoCarta ExoCarta_5594
Vesiclepedia VP_5594
Entrez Gene 5594
HGNC 6871
MIM 176948
UniProt P28482  
 MAPK1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Endothelial cells 26027894    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocytes 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Pluripotent stem cells 34108659    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for MAPK1
Molecular Function
    phosphotyrosine residue binding GO:0001784 IEA
    DNA binding GO:0003677 IEA
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    JUN kinase activity GO:0004705 IEA
    MAP kinase activity GO:0004707 IDA
    MAP kinase activity GO:0004707 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    RNA polymerase II CTD heptapeptide repeat kinase activity GO:0008353 ISS
    phosphatase binding GO:0019902 IPI
    identical protein binding GO:0042802 IPI
    protein serine kinase activity GO:0106310 IEA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein phosphorylation GO:0006468 IDA
    protein phosphorylation GO:0006468 TAS
    apoptotic process GO:0006915 IEA
    chemotaxis GO:0006935 TAS
    DNA damage response GO:0006974 IEA
    signal transduction GO:0007165 TAS
    cell surface receptor signaling pathway GO:0007166 IBA
    JNK cascade GO:0007254 IEA
    chemical synaptic transmission GO:0007268 TAS
    learning or memory GO:0007611 NAS
    insulin receptor signaling pathway GO:0008286 IEA
    positive regulation of macrophage chemotaxis GO:0010759 IGI
    positive regulation of peptidyl-threonine phosphorylation GO:0010800 IDA
    Schwann cell development GO:0014044 IEA
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-threonine phosphorylation GO:0018107 ISS
    cytosine metabolic process GO:0019858 IEA
    regulation of ossification GO:0030278 IEA
    androgen receptor signaling pathway GO:0030521 IMP
    regulation of cellular pH GO:0030641 IEA
    thyroid gland development GO:0030878 IEA
    regulation of protein stability GO:0031647 ISS
    lipopolysaccharide-mediated signaling pathway GO:0031663 IEA
    positive regulation of telomere maintenance GO:0032206 IMP
    regulation of stress-activated MAPK cascade GO:0032872 TAS
    mammary gland epithelial cell proliferation GO:0033598 IEA
    cellular response to amino acid starvation GO:0034198 IDA
    response to nicotine GO:0035094 ISS
    intracellular signal transduction GO:0035556 IBA
    ERBB signaling pathway GO:0038127 IDA
    ERBB2-ERBB3 signaling pathway GO:0038133 IEA
    outer ear morphogenesis GO:0042473 IEA
    myelination GO:0042552 IEA
    response to exogenous dsRNA GO:0043330 IEA
    steroid hormone receptor signaling pathway GO:0043401 IMP
    positive regulation of cholesterol biosynthetic process GO:0045542 IDA
    negative regulation of cell differentiation GO:0045596 IEA
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    thymus development GO:0048538 IEA
    progesterone receptor signaling pathway GO:0050847 IMP
    T cell receptor signaling pathway GO:0050852 IEA
    B cell receptor signaling pathway GO:0050853 IEA
    stress-activated MAPK cascade GO:0051403 IDA
    regulation of cytoskeleton organization GO:0051493 TAS
    Bergmann glial cell differentiation GO:0060020 IEA
    long-term synaptic potentiation GO:0060291 IEA
    face development GO:0060324 IEA
    lung morphogenesis GO:0060425 IEA
    trachea formation GO:0060440 IEA
    labyrinthine layer blood vessel development GO:0060716 IEA
    cardiac neural crest cell development involved in heart development GO:0061308 IEA
    ERK1 and ERK2 cascade GO:0070371 IC
    ERK1 and ERK2 cascade GO:0070371 IDA
    response to epidermal growth factor GO:0070849 IDA
    cellular response to tumor necrosis factor GO:0071356 IEA
    caveolin-mediated endocytosis GO:0072584 TAS
    regulation of Golgi inheritance GO:0090170 TAS
    positive regulation of macrophage proliferation GO:0120041 IGI
    regulation of early endosome to late endosome transport GO:2000641 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 HDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISS
    mitochondrion GO:0005739 TAS
    early endosome GO:0005769 TAS
    late endosome GO:0005770 TAS
    endoplasmic reticulum lumen GO:0005788 TAS
    Golgi apparatus GO:0005794 TAS
    centrosome GO:0005813 IEA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 TAS
    plasma membrane GO:0005886 ISS
    caveola GO:0005901 ISS
    caveola GO:0005901 TAS
    focal adhesion GO:0005925 TAS
    pseudopodium GO:0031143 IEA
    azurophil granule lumen GO:0035578 TAS
    synapse GO:0045202 IEA
    mitotic spindle GO:0072686 ISS
    ficolin-1-rich granule lumen GO:1904813 TAS
 Experiment description of studies that identified MAPK1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
12
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
13
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
18
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
19
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
23
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
26
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
29
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
30
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
31
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
32
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
35
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
36
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
38
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
39
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
40
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
41
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
42
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
43
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
44
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
45
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
46
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MAPK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 GSTP1 2950
Affinity Capture-Western Homo sapiens
3 DGCR8  
Affinity Capture-MS Homo sapiens
4 RPS6KA5 9252
Phenotypic Enhancement Homo sapiens
5 ILKAP 80895
Co-fractionation Homo sapiens
6 Eif4ebp1  
Biochemical Activity Rattus norvegicus
Biochemical Activity Rattus norvegicus
7 HDAC4  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
8 TNIP1 10318
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 ARHGEF2 9181
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
10 SMAD1 4086
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
11 SARS2 54938
Co-fractionation Homo sapiens
12 IFI35 3430
Two-hybrid Homo sapiens
13 SHC1 6464
Affinity Capture-Western Homo sapiens
14 STAT5B 6777
Co-fractionation Homo sapiens
15 CENPE 1062
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
16 CDKN2C  
Affinity Capture-MS Homo sapiens
17 TSC2 7249
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
18 ZNF444  
Affinity Capture-MS Homo sapiens
19 STAT5A 6776
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
20 PKM 5315
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
21 ARHGEF26 26084
Affinity Capture-MS Homo sapiens
22 cic  
Two-hybrid Drosophila melanogaster
Biochemical Activity Drosophila melanogaster
23 DUSP8  
Affinity Capture-MS Homo sapiens
24 DAPK1 1612
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
25 SP1  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
26 PDCD1  
Affinity Capture-Western Homo sapiens
27 MKNK2 2872
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
28 EPB41L5 57669
Affinity Capture-MS Homo sapiens
29 DHPS 1725
Affinity Capture-MS Homo sapiens
30 BRCA1 672
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
31 CAPZA1 829
Co-fractionation Homo sapiens
32 JUND 3727
Affinity Capture-Western Homo sapiens
33 CEBPB  
Biochemical Activity Homo sapiens
34 RPS6KA4 8986
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
35 KARS 3735
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
36 SYNE2 23224
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 PGR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
38 HNRNPR 10236
Co-fractionation Homo sapiens
39 RET 5979
Co-localization Homo sapiens
40 PEBP1 5037
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
41 SPAG9 9043
Affinity Capture-MS Homo sapiens
42 SOX10  
Biochemical Activity Homo sapiens
43 TH  
Biochemical Activity Homo sapiens
44 GAB2 9846
Biochemical Activity Homo sapiens
45 RFFL 117584
Affinity Capture-MS Homo sapiens
46 CLIC5 53405
Affinity Capture-MS Homo sapiens
47 HMMR  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
48 PPP1CC 5501
Affinity Capture-Western Homo sapiens
49 CTSD 1509
Two-hybrid Homo sapiens
50 WTAP 9589
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
51 RPS6KA3 6197
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 TOP2A 7153
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
53 UXS1 80146
Affinity Capture-MS Homo sapiens
54 ERF  
Affinity Capture-MS Homo sapiens
55 FGF5  
Co-localization Homo sapiens
56 FCGR2B  
Reconstituted Complex Homo sapiens
57 MCM2 4171
Affinity Capture-MS Homo sapiens
58 PRDX6 9588
Biochemical Activity Homo sapiens
59 PPP2R5C 5527
Biochemical Activity Homo sapiens
60 COPS6 10980
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
61 NAV1 89796
Affinity Capture-MS Homo sapiens
62 NUP153 9972
Reconstituted Complex Homo sapiens
63 WDR83  
Affinity Capture-Western Homo sapiens
64 RPS6KA6 27330
Affinity Capture-MS Homo sapiens
65 FAM83D 81610
Affinity Capture-MS Homo sapiens
66 SPANXN4  
Affinity Capture-MS Homo sapiens
67 Top2a 21973
Reconstituted Complex Mus musculus
68 IQGAP1 8826
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
69 SRC 6714
Affinity Capture-Western Homo sapiens
70 STAT3 6774
Affinity Capture-Western Homo sapiens
71 PHF14 9678
Affinity Capture-MS Homo sapiens
72 NRL  
Biochemical Activity Homo sapiens
73 DUSP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 MAPK14 1432
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
75 CUEDC2  
Biochemical Activity Homo sapiens
76 KDR  
Biochemical Activity Homo sapiens
77 NCOA3  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
78 PTPRR  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
79 ABCE1 6059
Affinity Capture-MS Homo sapiens
80 AGTR1  
Affinity Capture-Western Homo sapiens
81 PEA15 8682
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
82 LAMTOR3 8649
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
83 PPP2R5B 5526
Biochemical Activity Homo sapiens
84 ALK 238
Affinity Capture-MS Homo sapiens
85 TULP3 7289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 Prdx6 94167
Biochemical Activity Rattus norvegicus
87 TCF20  
Affinity Capture-MS Homo sapiens
88 MECP2 4204
Affinity Capture-MS Homo sapiens
89 RPS6KA2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 TFCP2 7024
Biochemical Activity Homo sapiens
91 VDR  
Biochemical Activity Homo sapiens
92 ESR2  
Biochemical Activity Homo sapiens
93 GNPTAB 79158
Two-hybrid Homo sapiens
94 CHEK2  
Co-fractionation Homo sapiens
95 PTPRF 5792
Co-fractionation Homo sapiens
96 ARHGAP9 64333
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
97 NTMT1 28989
Co-fractionation Homo sapiens
98 GSK3B 2932
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
99 PRNP 5621
Affinity Capture-MS Homo sapiens
100 DYRK1B  
Biochemical Activity Homo sapiens
101 CDKN2A 1029
Affinity Capture-MS Homo sapiens
102 GTF2I 2969
Affinity Capture-Western Homo sapiens
103 MAPK1 5594
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
104 GPS2  
Affinity Capture-MS Homo sapiens
105 RABGEF1 27342
Affinity Capture-Western Homo sapiens
106 PLA2G4A 5321
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
107 GATA4  
Biochemical Activity Homo sapiens
108 VAV1 7409
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
109 MAPK3 5595
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
110 RIN3  
Affinity Capture-MS Homo sapiens
111 NEB 4703
Co-fractionation Homo sapiens
112 BCL2L11  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
113 MAPK12  
Affinity Capture-MS Homo sapiens
114 PARK2  
Affinity Capture-Western Homo sapiens
115 CDKN2B 1030
Affinity Capture-MS Homo sapiens
116 GRN 2896
Affinity Capture-MS Homo sapiens
117 CAPZB 832
Affinity Capture-MS Homo sapiens
118 GOLPH3L 55204
Co-fractionation Homo sapiens
119 ATF2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
120 TPD52 7163
Affinity Capture-Western Homo sapiens
121 GCC2 9648
Affinity Capture-MS Homo sapiens
122 STAB2 55576
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 UBR5 51366
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
124 PTPRE 5791
Affinity Capture-Western Homo sapiens
125 ATM 472
Biochemical Activity Homo sapiens
126 SREBF2 6721
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
127 BARD1 580
Affinity Capture-MS Homo sapiens
128 TTN 7273
Biochemical Activity Homo sapiens
Synthetic Lethality Homo sapiens
129 NTRK1 4914
Affinity Capture-MS Homo sapiens
130 CRKL 1399
Co-localization Homo sapiens
131 SURF6  
Affinity Capture-MS Homo sapiens
132 SMAD3 4088
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
133 PTGDR  
Affinity Capture-Western Homo sapiens
134 CRP  
Two-hybrid Homo sapiens
135 CHEK1  
Co-fractionation Homo sapiens
136 PPP1R21 129285
Affinity Capture-MS Homo sapiens
137 HUWE1 10075
Affinity Capture-MS Homo sapiens
138 FH 2271
Synthetic Lethality Homo sapiens
139 RNF25 64320
Co-fractionation Homo sapiens
140 UBTF 7343
Biochemical Activity Homo sapiens
141 PML 5371
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
142 SNRNP27  
Affinity Capture-MS Homo sapiens
143 BRAF  
Synthetic Lethality Homo sapiens
Biochemical Activity Homo sapiens
144 Tiam2  
Affinity Capture-MS Mus musculus
145 EIF4EBP1  
Biochemical Activity Homo sapiens
146 SREBF1 6720
Biochemical Activity Homo sapiens
147 REST 5978
Biochemical Activity Homo sapiens
148 ENAH 55740
Two-hybrid Homo sapiens
149 Ksr1  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
150 PRKCE 5581
Affinity Capture-Western Homo sapiens
151 HIST1H2AB 8335
Co-localization Homo sapiens
152 RMDN3 55177
Co-localization Homo sapiens
153 CACYBP 27101
Biochemical Activity Homo sapiens
154 VCP 7415
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 MAP2K7 5609
Protein-peptide Homo sapiens
156 DUSP7  
Affinity Capture-MS Homo sapiens
157 ATP6V1D 51382
Co-fractionation Homo sapiens
158 ARRB1 408
Biochemical Activity Homo sapiens
159 STYX  
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
160 XPO5 57510
Co-fractionation Homo sapiens
161 DOK2 9046
Affinity Capture-MS Homo sapiens
162 RRM2 6241
Co-fractionation Homo sapiens
163 SFPQ 6421
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
164 DUSP1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
165 HSF1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
166 MINOS1  
Affinity Capture-MS Homo sapiens
167 PRKCA 5578
Co-fractionation Homo sapiens
168 PRKCD 5580
Co-fractionation Homo sapiens
169 TP53BP1 7158
Affinity Capture-MS Homo sapiens
170 TRPS1  
Affinity Capture-MS Homo sapiens
171 Rps6ka3 110651
Affinity Capture-Western Mus musculus
172 EGLN3  
Two-hybrid Homo sapiens
173 TPR 7175
Biochemical Activity Homo sapiens
174 ECT2 1894
Affinity Capture-MS Homo sapiens
175 RALB 5899
Affinity Capture-MS Homo sapiens
176 MTIF3  
Two-hybrid Homo sapiens
177 PPARG 5468
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
178 GORASP2 26003
Biochemical Activity Homo sapiens
179 FERMT2 10979
Co-fractionation Homo sapiens
180 LMNB2 84823
Co-fractionation Homo sapiens
181 MAPKAPK2 9261
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
182 TNFRSF1A 7132
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
183 PDE4D  
Biochemical Activity Homo sapiens
184 HMGB1 3146
Affinity Capture-MS Homo sapiens
185 CSNK2A1 1457
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
186 ZC3HC1  
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
187 MAP3K1 4214
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
188 CIITA  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
189 PTK2 5747
Co-fractionation Homo sapiens
190 IER3  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
191 PRPSAP1 5635
Two-hybrid Homo sapiens
192 DUSP16  
Affinity Capture-Western Homo sapiens
193 CORO1C 23603
Co-fractionation Homo sapiens
194 TNIP2  
Two-hybrid Homo sapiens
195 DUSP6 1848
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
196 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
197 XPO6 23214
Co-fractionation Homo sapiens
198 JUN 3725
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
199 ELK1  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
200 CDC25C  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
201 TNKS2 80351
Biochemical Activity Homo sapiens
202 C1QBP 708
Biochemical Activity Homo sapiens
203 ICK  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
204 FOS 2353
Affinity Capture-Western Homo sapiens
205 ID2  
Two-hybrid Homo sapiens
206 PTPN7 5778
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
207 RPA3 6119
Proximity Label-MS Homo sapiens
208 DNM1L 10059
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
209 CITED2  
Biochemical Activity Homo sapiens
210 CDK4 1019
Affinity Capture-MS Homo sapiens
211 TXNIP 10628
Biochemical Activity Homo sapiens
212 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
213 MAPKAPK5 8550
Co-localization Homo sapiens
214 PTPDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
215 ETS1  
Co-localization Homo sapiens
216 DCC  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
217 RAI1 10743
Affinity Capture-MS Homo sapiens
218 SORBS3 10174
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
219 DUSP9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
220 RAF1 5894
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
221 RPS11 6205
Synthetic Lethality Homo sapiens
222 ITPK1 3705
Co-fractionation Homo sapiens
223 VDAC1 7416
Co-localization Homo sapiens
224 BLVRA 644
Co-fractionation Homo sapiens
225 TOB1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
226 CDKN2D  
Affinity Capture-MS Homo sapiens
227 SCRN3 79634
Affinity Capture-MS Homo sapiens
228 CEBPA  
Protein-peptide Homo sapiens
229 CCND1 595
Affinity Capture-Western Homo sapiens
230 CEP350 9857
Affinity Capture-MS Homo sapiens
231 FHL2 2274
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
232 C9orf72  
Affinity Capture-MS Homo sapiens
233 FOXO3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
234 Rps6kb1  
Reconstituted Complex Mus musculus
235 FAM133A 286499
Affinity Capture-MS Homo sapiens
236 MTOR 2475
Synthetic Lethality Homo sapiens
237 HIF1A 3091
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
238 DUSP19  
Affinity Capture-MS Homo sapiens
239 YBX1 4904
Biochemical Activity Homo sapiens
240 SNCA 6622
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
241 MAP2K2 5605
Two-hybrid Homo sapiens
PCA Homo sapiens
242 ARRB2 409
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
243 ADAM17 6868
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
244 MAP2K6 5608
Biochemical Activity Homo sapiens
245 RARA 5914
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
246 MTPN 136319
Two-hybrid Homo sapiens
247 SHANK3 85358
Two-hybrid Homo sapiens
248 MPP2 4355
Affinity Capture-MS Homo sapiens
249 SUPT20H 55578
Two-hybrid Homo sapiens
250 TNFRSF25  
Biochemical Activity Homo sapiens
251 HSF4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
252 TP53 7157
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
253 MKNK1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
254 PDCD6IP 10015
Affinity Capture-MS Homo sapiens
255 IPP  
Affinity Capture-MS Homo sapiens
256 HDAC6 10013
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
257 DUSP3 1845
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
258 PHF3  
Affinity Capture-MS Homo sapiens
259 SNCG 6623
Affinity Capture-Western Homo sapiens
260 RYK 6259
Affinity Capture-MS Homo sapiens
261 CASP8 841
Affinity Capture-Western Homo sapiens
262 RPTOR 57521
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
263 DNAAF5 54919
Co-fractionation Homo sapiens
264 SQSTM1 8878
Affinity Capture-Western Homo sapiens
265 HNF4A  
Biochemical Activity Homo sapiens
266 INSR 3643
Affinity Capture-Western Homo sapiens
267 LAMTOR2 28956
Co-fractionation Homo sapiens
268 CREBBP  
Biochemical Activity Homo sapiens
269 ITGB6 3694
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
270 OTUB1 55611
Affinity Capture-MS Homo sapiens
271 C19orf25  
Affinity Capture-MS Homo sapiens
272 ADAM15 8751
Affinity Capture-Western Homo sapiens
273 DUSP12 11266
Affinity Capture-MS Homo sapiens
274 MAP2K1 5604
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
275 PFKM 5213
Co-fractionation Homo sapiens
276 ESR1  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
277 MBP 4155
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
278 ITGAV 3685
Affinity Capture-Western Homo sapiens
279 PTPN5  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
280 PECAM1 5175
Affinity Capture-Western Homo sapiens
281 C10orf88  
Affinity Capture-MS Homo sapiens
282 NEK2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
283 GAPDH 2597
Two-hybrid Homo sapiens
284 EYA4 2070
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
285 KRT8 3856
Biochemical Activity Homo sapiens
286 ME1 4199
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
287 C16orf72 29035
Affinity Capture-MS Homo sapiens
288 YBX3 8531
Biochemical Activity Homo sapiens
289 RXRA 6256
Biochemical Activity Homo sapiens
290 PXN 5829
Co-localization Homo sapiens
Co-fractionation Homo sapiens
291 ATP1A1 476
Biochemical Activity Homo sapiens
292 DCUN1D1 54165
Co-fractionation Homo sapiens
293 SLC9A3R1 9368
Co-fractionation Homo sapiens
294 HIST1H4A 8359
Co-localization Homo sapiens
295 METTL3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
296 RPRD1B 58490
Co-fractionation Homo sapiens
297 CASP9 842
Biochemical Activity Homo sapiens
298 DUSP4 1846
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
299 SERBP1 26135
Affinity Capture-MS Homo sapiens
300 Top2  
Biochemical Activity Drosophila melanogaster
301 CUL7 9820
Affinity Capture-MS Homo sapiens
302 KRAS 3845
Synthetic Lethality Homo sapiens
Affinity Capture-Western Homo sapiens
303 ECM1 1893
Affinity Capture-MS Homo sapiens
304 AR 367
Reconstituted Complex Homo sapiens
305 KLF11  
Biochemical Activity Homo sapiens
306 MYC  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
307 CUEDC1 404093
Affinity Capture-MS Homo sapiens
308 PAX5  
Biochemical Activity Homo sapiens
309 CAV1 857
Affinity Capture-Western Homo sapiens
310 RPS6KA1 6195
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
311 Dusp9  
Two-hybrid Mus musculus
Biochemical Activity Mus musculus
312 NOTCH1 4851
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
313 EP300 2033
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
314 CAPN2 824
Biochemical Activity Homo sapiens
315 NPTX2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MAPK1 is involved
PathwayEvidenceSource
Activation of NMDA receptors and postsynaptic events IEA Reactome
Activation of the AP-1 family of transcription factors TAS Reactome
Advanced glycosylation endproduct receptor signaling IEA Reactome
Apoptosis TAS Reactome
Apoptotic factor-mediated response TAS Reactome
Axon guidance TAS Reactome
Bacterial Infection Pathways TAS Reactome
Ca-dependent events TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular response to heat stress TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress TAS Reactome
Cellular responses to stress IEA Reactome
Cellular Senescence TAS Reactome
Cellular Senescence IEA Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling IEA Reactome
Cytochrome c-mediated apoptotic response TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity TAS Reactome
ERK/MAPK targets TAS Reactome
ERK/MAPK targets IEA Reactome
ERKs are inactivated TAS Reactome
ESR-mediated signaling IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent nuclear events downstream of ESR-membrane signaling IEA Reactome
Estrogen-dependent nuclear events downstream of ESR-membrane signaling TAS Reactome
Estrogen-stimulated signaling through PRKCZ TAS Reactome
Extra-nuclear estrogen signaling IEA Reactome
Extra-nuclear estrogen signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated MAPK activation TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
FCGR3A-mediated phagocytosis TAS Reactome
Formation of apoptosome TAS Reactome
Frs2-mediated activation TAS Reactome
G alpha (i) signalling events TAS Reactome
G alpha (q) signalling events TAS Reactome
G-protein mediated events TAS Reactome
Gastrin-CREB signalling pathway via PKC and MAPK TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway IEA Reactome
Generic Transcription Pathway TAS Reactome
Golgi Cisternae Pericentriolar Stack Reorganization TAS Reactome
GPCR downstream signalling TAS Reactome
Growth hormone receptor signaling TAS Reactome
Hemostasis TAS Reactome
IFNG signaling activates MAPKs TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infection with Mycobacterium tuberculosis TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Insulin receptor signalling cascade TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome
Interleukin-17 signaling TAS Reactome
Interleukin-17 signaling IEA Reactome
Intracellular signaling by second messengers TAS Reactome
Intrinsic Pathway for Apoptosis TAS Reactome
L1CAM interactions TAS Reactome
Leishmania infection TAS Reactome
Leishmania phagocytosis TAS Reactome
M Phase TAS Reactome
MAP kinase activation TAS Reactome
MAP kinase activation IEA Reactome
MAP2K and MAPK activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK targets/ Nuclear events mediated by MAP kinases TAS Reactome
MAPK targets/ Nuclear events mediated by MAP kinases IEA Reactome
MAPK1 (ERK2) activation TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MITF-M-regulated melanocyte development TAS Reactome
Mitotic Prophase TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 cascade initiated on plasma membrane IEA Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88 dependent cascade initiated on endosome IEA Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88-independent TLR4 cascade IEA Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane IEA Reactome
NCAM signaling for neurite out-growth TAS Reactome
Negative feedback regulation of MAPK pathway TAS Reactome
Negative regulation of FGFR1 signaling TAS Reactome
Negative regulation of FGFR2 signaling TAS Reactome
Negative regulation of FGFR3 signaling TAS Reactome
Negative regulation of FGFR4 signaling TAS Reactome
Negative regulation of MAPK pathway TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nervous system development TAS Reactome
Neuronal System IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Neutrophil degranulation TAS Reactome
NPAS4 regulates expression of target genes IEA Reactome
NPAS4 regulates expression of target genes TAS Reactome
Nuclear Events (kinase and transcription factor activation) TAS Reactome
Nuclear Events (kinase and transcription factor activation) IEA Reactome
Nuclear events stimulated by ALK signaling in cancer TAS Reactome
Oncogene Induced Senescence TAS Reactome
Oncogene Induced Senescence IEA Reactome
Oncogenic MAPK signaling TAS Reactome
Opioid Signalling TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
Parasite infection TAS Reactome
Parasitic Infection Pathways TAS Reactome
phospho-PLA2 pathway TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
PLC beta mediated events TAS Reactome
Post NMDA receptor activation events IEA Reactome
Programmed Cell Death TAS Reactome
Prolonged ERK activation events TAS Reactome
PTEN Regulation TAS Reactome
RAF-independent MAPK1/3 activation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Recycling pathway of L1 TAS Reactome
Regulation of actin dynamics for phagocytic cup formation TAS Reactome
Regulation of HSF1-mediated heat shock response TAS Reactome
Regulation of PTEN gene transcription TAS Reactome
Regulation of the apoptosome activity TAS Reactome
Response of Mtb to phagocytosis TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases Activate NADPH Oxidases TAS Reactome
RHO GTPases Activate WASPs and WAVEs TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RSK activation IEA Reactome
RUNX2 regulates bone development IEA Reactome
RUNX2 regulates osteoblast differentiation IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal attenuation TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signal transduction by L1 TAS Reactome
Signaling by Activin TAS Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR1 TAS Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR3 TAS Reactome
Signaling by FGFR4 TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by high-kinase activity BRAF mutants TAS Reactome
Signaling by Insulin receptor TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by LTK in cancer TAS Reactome
Signaling by MAP2K mutants TAS Reactome
Signaling by MAPK mutants TAS Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by NODAL TAS Reactome
Signaling by NTRK1 (TRKA) TAS Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs TAS Reactome
Signaling by NTRKs IEA Reactome
Signaling by Nuclear Receptors IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by TGF-beta Receptor Complex TAS Reactome
Signaling by TGFB family members TAS Reactome
Signaling downstream of RAS mutants TAS Reactome
Signalling to ERKs TAS Reactome
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TAS Reactome
Spry regulation of FGF signaling TAS Reactome
Suppression of apoptosis TAS Reactome
Thrombin signalling through proteinase activated receptors (PARs) TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade IEA Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade IEA Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade IEA Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade IEA Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade IEA Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade IEA Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade IEA Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade IEA Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade IEA Reactome
Toll-like Receptor Cascades TAS Reactome
Toll-like Receptor Cascades IEA Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IEA Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer TAS Reactome
Transcriptional and post-translational regulation of MITF-M expression and activity TAS Reactome
Transcriptional Regulation by NPAS4 IEA Reactome
Transcriptional Regulation by NPAS4 TAS Reactome
Transcriptional regulation by RUNX2 IEA Reactome
Transmission across Chemical Synapses IEA Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling IEA Reactome





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