Gene description for CCND1
Gene name cyclin D1
Gene symbol CCND1
Other names/aliases BCL1
D11S287E
PRAD1
U21B31
Species Homo sapiens
 Database cross references - CCND1
ExoCarta ExoCarta_595
Vesiclepedia VP_595
Entrez Gene 595
HGNC 1582
MIM 168461
UniProt P24385  
 CCND1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CCND1
Molecular Function
    transcription corepressor activity GO:0003714 IDA
    protein kinase activity GO:0004672 IEA
    protein binding GO:0005515 IPI
    cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 IBA
    enzyme binding GO:0019899 IPI
    protein kinase binding GO:0019901 IPI
    histone deacetylase binding GO:0042826 IPI
    cyclin-dependent protein serine/threonine kinase activator activity GO:0061575 IDA
    cyclin-dependent protein serine/threonine kinase activator activity GO:0061575 TAS
    proline-rich region binding GO:0070064 IDA
Biological Process
    G1/S transition of mitotic cell cycle GO:0000082 IBA
    G1/S transition of mitotic cell cycle GO:0000082 IDA
    G1/S transition of mitotic cell cycle GO:0000082 NAS
    G1/S transition of mitotic cell cycle GO:0000082 TAS
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    re-entry into mitotic cell cycle GO:0000320 IEA
    positive regulation of protein phosphorylation GO:0001934 IDA
    DNA damage response GO:0006974 IDA
    lactation GO:0007595 IEA
    response to xenobiotic stimulus GO:0009410 IEP
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IDA
    Wnt signaling pathway GO:0016055 IEA
    neuron differentiation GO:0030182 IEA
    negative regulation of epithelial cell differentiation GO:0030857 IEA
    endoplasmic reticulum unfolded protein response GO:0030968 IEA
    mitotic G1 DNA damage checkpoint signaling GO:0031571 IDA
    mammary gland epithelial cell proliferation GO:0033598 IEA
    positive regulation of mammary gland epithelial cell proliferation GO:0033601 IEA
    negative regulation of neuron apoptotic process GO:0043524 IEA
    response to leptin GO:0044321 IDA
    fat cell differentiation GO:0045444 IEA
    positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 IDA
    cell division GO:0051301 IEA
    mammary gland alveolus development GO:0060749 IEA
    response to UV-A GO:0070141 IDA
    liver regeneration GO:0097421 IEA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IBA
Subcellular Localization
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 IBA
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    microtubule organizing center GO:0005815 IBA
    cytosol GO:0005829 TAS
    bicellular tight junction GO:0005923 IEA
    transcription repressor complex GO:0017053 IDA
    nuclear membrane GO:0031965 IEA
    cyclin D1-CDK4 complex GO:0097128 IPI
    cyclin D1-CDK6 complex GO:0097131 IPI
 Experiment description of studies that identified CCND1 in sEVs
1
Experiment ID 235
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CCND1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 PSMA6 5687
Affinity Capture-Western Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 MCM7 4176
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
5 PPP1CB 5500
Affinity Capture-Western Homo sapiens
6 HDAC2 3066
Affinity Capture-Western Homo sapiens
7 ORC4  
Reconstituted Complex Homo sapiens
8 TSC2 7249
Affinity Capture-Western Homo sapiens
9 USP13  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 SP1  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
11 USP5 8078
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 Oaz1  
Reconstituted Complex Rattus norvegicus
13 BRCA1 672
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
14 TAF1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 DCAF8 50717
Affinity Capture-MS Homo sapiens
16 PPP1CC 5501
Affinity Capture-Western Homo sapiens
17 HDAC3 8841
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
18 NCOR1  
Co-fractionation Homo sapiens
19 BTRC 8945
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
20 MCM2 4171
Affinity Capture-Western Homo sapiens
21 TBL1XR1 79718
Co-fractionation Homo sapiens
22 KDM2A  
Affinity Capture-MS Homo sapiens
23 FZR1  
Affinity Capture-Western Homo sapiens
24 STAT3 6774
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
25 FBXW8 26259
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 NCOA3  
Affinity Capture-Western Homo sapiens
27 BRINP1  
Two-hybrid Homo sapiens
28 LRRC41 10489
Affinity Capture-MS Homo sapiens
29 CDKN1C  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 BRD4 23476
Co-localization Homo sapiens
31 ATG7 10533
Affinity Capture-MS Homo sapiens
32 MAPK11  
Biochemical Activity Homo sapiens
33 USP2  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
34 MCM6 4175
Affinity Capture-Western Homo sapiens
35 CUL1 8454
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
36 CCNDBP1 23582
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
37 NPAS1  
Affinity Capture-MS Homo sapiens
38 GSK3B 2932
Co-localization Homo sapiens
39 PCNA 5111
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
40 HSPA8 3312
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
41 NCOA1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
42 MAPK1 5594
Affinity Capture-Western Homo sapiens
43 RB1 5925
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
44 THRB 7068
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
45 RBX1 9978
Affinity Capture-Western Homo sapiens
46 FKBP6  
Affinity Capture-MS Homo sapiens
47 CDKN1A  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
48 CDK5 1020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 CTBP1 1487
Co-fractionation Homo sapiens
50 NCOR2  
Co-fractionation Homo sapiens
51 RABEP1 9135
Two-hybrid Homo sapiens
52 SMU1 55234
Affinity Capture-MS Homo sapiens
53 MCM10 55388
Reconstituted Complex Homo sapiens
54 ATF2  
Reconstituted Complex Homo sapiens
55 WDR61 80349
Affinity Capture-MS Homo sapiens
56 DTNBP1  
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
57 MKRN2 23609
Affinity Capture-RNA Homo sapiens
58 TSR3  
Affinity Capture-MS Homo sapiens
59 NPDC1  
Reconstituted Complex Homo sapiens
60 DCAF10  
Affinity Capture-MS Homo sapiens
61 NEUROD1  
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
62 UBTF 7343
Biochemical Activity Homo sapiens
63 TCHH  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 CDC27 996
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
65 FBXO31 79791
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
66 UBXN6 80700
Affinity Capture-MS Homo sapiens
67 SLC25A5 292
Affinity Capture-MS Homo sapiens
68 FBXO4 26272
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
69 MIER1  
Co-fractionation Homo sapiens
70 CCNA2 890
Co-fractionation Homo sapiens
71 PAFAH1B1 5048
Affinity Capture-MS Homo sapiens
72 DCAF7 10238
Affinity Capture-MS Homo sapiens
73 AMBRA1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
74 XPO1 7514
Reconstituted Complex Homo sapiens
75 ATP2B1 490
Affinity Capture-MS Homo sapiens
76 CRYAB 1410
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
77 CTNNB1 1499
Co-localization Homo sapiens
78 SKP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
79 CARD11  
Affinity Capture-Western Homo sapiens
80 UHRF2  
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
81 POLR2A 5430
Co-localization Homo sapiens
82 RBBP4 5928
Affinity Capture-MS Homo sapiens
83 NXF1 10482
Affinity Capture-RNA Homo sapiens
84 THRA  
Affinity Capture-Western Homo sapiens
85 AKAP8  
Affinity Capture-Western Homo sapiens
86 RANBP9 10048
Two-hybrid Homo sapiens
87 CDK2 1017
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
88 ESM1 11082
Co-localization Homo sapiens
89 DNAI2  
Affinity Capture-MS Homo sapiens
90 RBL2 5934
Two-hybrid Homo sapiens
91 LPL 4023
Two-hybrid Homo sapiens
92 CDKN1B 1027
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
93 CCND1 595
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
94 TP73  
Reconstituted Complex Homo sapiens
95 MDM2  
Affinity Capture-Western Homo sapiens
96 CDKN2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 DZIP3  
Affinity Capture-RNA Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Protein-RNA Homo sapiens
Affinity Capture-Western Homo sapiens
98 RELA 5970
Affinity Capture-Western Homo sapiens
99 INSM1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
100 RBPJ 3516
Co-fractionation Homo sapiens
101 TOR1AIP2 163590
Affinity Capture-MS Homo sapiens
102 RFC1 5981
Affinity Capture-Western Homo sapiens
103 HDGF 3068
Co-fractionation Homo sapiens
104 WDR77 79084
Affinity Capture-Western Homo sapiens
105 BTD 686
Affinity Capture-MS Homo sapiens
106 TP53 7157
Affinity Capture-Western Homo sapiens
107 POLR1B 84172
Two-hybrid Homo sapiens
108 NLE1 54475
Affinity Capture-MS Homo sapiens
109 KAT2B  
Affinity Capture-Western Homo sapiens
110 ITLN1 55600
Dosage Rescue Homo sapiens
111 SKP1 6500
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
112 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
113 HDAC1 3065
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
114 PRMT5 10419
Affinity Capture-Western Homo sapiens
115 CDK6 1021
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
116 CDK1 983
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 PSMD7 5713
Affinity Capture-Western Homo sapiens
118 ESR1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
119 MCM3 4172
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
120 REV3L  
Affinity Capture-MS Homo sapiens
121 IGF2BP3 10643
Affinity Capture-RNA Homo sapiens
122 CDK4 1019
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
123 Mybl2  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
124 CDK9 1025
Co-localization Homo sapiens
125 CDKN2A 1029
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
126 CUL7 9820
Affinity Capture-Western Homo sapiens
127 KRAS 3845
Negative Genetic Homo sapiens
128 ARID4A  
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
129 AR 367
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
130 RCOR1  
Co-fractionation Homo sapiens
131 EP300 2033
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
132 HERC5 51191
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which CCND1 is involved
PathwayEvidenceSource
Aberrant regulation of mitotic cell cycle due to RB1 defects TAS Reactome
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic TAS Reactome
Cell Cycle, Mitotic IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
Cyclin A:Cdk2-associated events at S phase entry TAS Reactome
Cyclin D associated events in G1 TAS Reactome
Cyclin E associated events during G1/S transition TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) TAS Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of mitotic cell cycle TAS Reactome
Drug-mediated inhibition of CDK4/CDK6 activity TAS Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Estrogen-dependent nuclear events downstream of ESR-membrane signaling TAS Reactome
Extra-nuclear estrogen signaling TAS Reactome
G1 Phase TAS Reactome
G1/S Transition TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Immune System TAS Reactome
Interleukin-4 and Interleukin-13 signaling TAS Reactome
MITF-M-dependent gene expression TAS Reactome
MITF-M-regulated melanocyte development TAS Reactome
Mitotic G1 phase and G1/S transition TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
PTK6 Regulates Cell Cycle TAS Reactome
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation TAS Reactome
Regulation of RUNX1 Expression and Activity TAS Reactome
RMTs methylate histone arginines TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RUNX3 regulates p14-ARF TAS Reactome
RUNX3 regulates WNT signaling TAS Reactome
S Phase TAS Reactome
S Phase IEA Reactome
SCF(Skp2)-mediated degradation of p27/p21 TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by Non-Receptor Tyrosine Kinases TAS Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by PTK6 TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX2 TAS Reactome
Transcriptional regulation by RUNX3 TAS Reactome
Transcriptional Regulation by VENTX TAS Reactome
Ubiquitin-dependent degradation of Cyclin D TAS Reactome
Ubiquitin-dependent degradation of Cyclin D IEA Reactome





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