Gene description for FBXO31
Gene name F-box protein 31
Gene symbol FBXO31
Other names/aliases FBX14
FBXO14
Fbx31
MRT45
pp2386
Species Homo sapiens
 Database cross references - FBXO31
ExoCarta ExoCarta_79791
Vesiclepedia VP_79791
Entrez Gene 79791
HGNC 16510
MIM 609102
UniProt Q5XUX0  
 FBXO31 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FBXO31
Molecular Function
    protein binding GO:0005515 IPI
    cyclin binding GO:0030332 IPI
Biological Process
    DNA damage response GO:0006974 IDA
    protein ubiquitination GO:0016567 IEA
    anaphase-promoting complex-dependent catabolic process GO:0031145 IMP
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IBA
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IDA
    mitotic G1 DNA damage checkpoint signaling GO:0031571 IMP
Subcellular Localization
    cytosol GO:0005829 TAS
    SCF ubiquitin ligase complex GO:0019005 IBA
    SCF ubiquitin ligase complex GO:0019005 IDA
    neuronal cell body GO:0043025 ISS
 Experiment description of studies that identified FBXO31 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FBXO31
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAM58A  
Affinity Capture-MS Homo sapiens
2 MRPS27 23107
Affinity Capture-MS Homo sapiens
3 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 MAP2K6 5608
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 FAM98A 25940
Affinity Capture-MS Homo sapiens
6 USP53 54532
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
7 PDLIM1 9124
Affinity Capture-MS Homo sapiens
8 DNAJC19 131118
Affinity Capture-MS Homo sapiens
9 PRPS1 5631
Affinity Capture-MS Homo sapiens
10 EFR3A 23167
Affinity Capture-MS Homo sapiens
11 CTNNB1 1499
Affinity Capture-Western Homo sapiens
12 SKP1 6500
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 ZCCHC9  
Affinity Capture-MS Homo sapiens
14 RBX1 9978
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 QSER1  
Affinity Capture-MS Homo sapiens
16 CFL1 1072
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
17 FBXL20 84961
Affinity Capture-Western Homo sapiens
18 MYC  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 MYH6 4624
Affinity Capture-MS Homo sapiens
20 STX3 6809
Affinity Capture-MS Homo sapiens
21 ZNF131  
Affinity Capture-MS Homo sapiens
22 FOXM1  
Affinity Capture-Western Homo sapiens
23 COPS5 10987
Affinity Capture-MS Homo sapiens
24 GHR  
Protein-peptide Homo sapiens
25 Kctd5  
Affinity Capture-MS Mus musculus
26 STYX  
Affinity Capture-MS Homo sapiens
27 CCND1 595
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
28 PARD6A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 CEP170P1  
Affinity Capture-MS Homo sapiens
30 C18orf21  
Affinity Capture-MS Homo sapiens
31 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
32 EDRF1  
Affinity Capture-MS Homo sapiens
33 CDT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
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