Gene description for FBXO31
Gene name F-box protein 31
Gene symbol FBXO31
Other names/aliases FBX14
FBXO14
Fbx31
MRT45
pp2386
Species Homo sapiens
 Database cross references - FBXO31
ExoCarta ExoCarta_79791
Entrez Gene 79791
HGNC 16510
MIM 609102
UniProt Q5XUX0  
 FBXO31 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FBXO31
Molecular Function
    cyclin binding GO:0030332 IPI
Biological Process
    negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation GO:0008054 IMP
    cellular response to DNA damage stimulus GO:0006974 IDA
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IDA
    protein ubiquitination GO:0016567 IEA
    mitotic G1 DNA damage checkpoint GO:0031571 IMP
Subcellular Localization
    SCF ubiquitin ligase complex GO:0019005 IDA
    neuronal cell body GO:0043025 ISS
 Experiment description of studies that identified FBXO31 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FBXO31
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FBXO31 is involved
No pathways found





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