Gene description for LPL
Gene name
lipoprotein lipase
Gene symbol
LPL
Other names/aliases
HDLCQ11 LIPD
Species
Homo sapiens
Database cross references - LPL
ExoCarta
ExoCarta_4023
Entrez Gene
4023
HGNC
6677
MIM
609708
UniProt
P06858
LPL identified in exosomes derived from the following tissue/cell type
Breast milk
17641064
Breast milk
17641064
Prostate cancer cells
25844599
Gene ontology annotations for LPL
Experiment description of studies that identified LPL in exosomes
1
Experiment ID
46
ISEV standards
✔
EM|IEM
EV Biophysical techniques
✔
HSC70
EV Cytosolic markers
✔
CD63|MHCII|CD81|CD86
EV Membrane markers
✔
CANX
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
17641064
Organism
Homo sapiens
Experiment description
Exosomes with immune modulatory features are present in human breast milk.
Authors
Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S
Journal name
JIMMU
Publication year
2007
Sample
Breast milk
Sample name
Breast milk - Colostrum
Isolation/purification methods
Differential centrifugation Filtration Sucrose density gradient
Flotation density
1.10-1.18 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry [QSTAR] Western blotting Immunoelectron Microscopy FACS
2
Experiment ID
48
ISEV standards
✔
EM|IEM
EV Biophysical techniques
✔
HSC70
EV Cytosolic markers
✔
CD63|CD86|MHCII
EV Membrane markers
✔
CANX
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
17641064
Organism
Homo sapiens
Experiment description
Exosomes with immune modulatory features are present in human breast milk.
Authors
Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S
Journal name
JIMMU
Publication year
2007
Sample
Breast milk
Sample name
Breast milk - Mature milk
Isolation/purification methods
Differential centrifugation Filtration Sucrose density gradient
Flotation density
1.10-1.18 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry [QSTAR] Western blotting Immunoelectron Microscopy FACS
3
Experiment ID
275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25844599
Organism
Homo sapiens
Experiment description
Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors
Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name
Oncotarget
Publication year
2015
Sample
Prostate cancer cells
Sample name
DU145 - Docetaxel sensitive
Isolation/purification methods
Filtration Ultracentrifugation Sucrose density gradient
Flotation density
1.12-1.19 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry/Flow cytometry/Western blotting
Protein-protein interactions for LPL
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
PTPN4
Two-hybrid
Homo sapiens
2
COPS6
10980
Two-hybrid
Homo sapiens
3
ASCC2
Two-hybrid
Homo sapiens
4
LRP1
4035
Invitro
Homo sapiens
Invitro
Homo sapiens
Invivo
Homo sapiens
Invitro
Homo sapiens
5
VLDLR
Invitro
Homo sapiens
6
UBE2Z
65264
Two-hybrid
Homo sapiens
7
EMD
Two-hybrid
Homo sapiens
8
RPL18A
6142
Two-hybrid
Homo sapiens
9
APOC2
344
Invitro
Homo sapiens
10
LUC7L2
Two-hybrid
Homo sapiens
11
KIAA1377
Two-hybrid
Homo sapiens
12
LRP2
4036
Reconstituted Complex
Homo sapiens
View the network
image/svg+xml
Pathways in which LPL is involved