Gene description for VLDLR
Gene name very low density lipoprotein receptor
Gene symbol VLDLR
Other names/aliases CAMRQ1
CARMQ1
CHRMQ1
VLDLRCH
Species Homo sapiens
 Database cross references - VLDLR
ExoCarta ExoCarta_7436
Vesiclepedia VP_7436
Entrez Gene 7436
HGNC 12698
MIM 192977
UniProt P98155  
 VLDLR identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for VLDLR
Molecular Function
    reelin receptor activity GO:0038025 ISS
    very-low-density lipoprotein particle binding GO:0034189 IDA
    protein binding GO:0005515 IPI
    glycoprotein transporter activity GO:0034437 IDA
    apolipoprotein binding GO:0034185 ISS
    low-density lipoprotein receptor activity GO:0005041 TAS
    very-low-density lipoprotein particle receptor activity GO:0030229 IDA
    calcium ion binding GO:0005509 IEA
    calcium-dependent protein binding GO:0048306 IPI
    glycoprotein binding GO:0001948 IPI
Biological Process
    very-low-density lipoprotein particle clearance GO:0034447 IDA
    signal transduction GO:0007165 TAS
    nervous system development GO:0007399 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    memory GO:0007613 TAS
    positive regulation of dendrite development GO:1900006 ISS
    ventral spinal cord development GO:0021517 IEA
    positive regulation of protein kinase activity GO:0045860 IEA
    receptor-mediated endocytosis GO:0006898 IDA
    cholesterol metabolic process GO:0008203 IEA
    reelin-mediated signaling pathway GO:0038026 ISS
    glycoprotein transport GO:0034436 IDA
    lipid transport GO:0006869 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    receptor complex GO:0043235 IDA
    coated pit GO:0005905 IEA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
    very-low-density lipoprotein particle GO:0034361 IEA
 Experiment description of studies that identified VLDLR in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VLDLR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD36 948
Reconstituted Complex Homo sapiens
2 RELN 5649
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
3 LRPAP1 4043
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
4 LPL 4023
Invitro Homo sapiens
5 SNX17 9784
Invivo Homo sapiens
Invitro Homo sapiens
6 CLU 1191
Far Western Homo sapiens
7 DAB1 1600
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which VLDLR is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here