Gene description for VLDLR
Gene name very low density lipoprotein receptor
Gene symbol VLDLR
Other names/aliases CAMRQ1
CARMQ1
CHRMQ1
VLDLRCH
Species Homo sapiens
 Database cross references - VLDLR
ExoCarta ExoCarta_7436
Vesiclepedia VP_7436
Entrez Gene 7436
HGNC 12698
MIM 192977
UniProt P98155  
 VLDLR identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for VLDLR
Molecular Function
    low-density lipoprotein particle receptor activity GO:0005041 TAS
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    very-low-density lipoprotein particle receptor activity GO:0030229 IDA
    very-low-density lipoprotein particle receptor activity GO:0030229 TAS
    apolipoprotein binding GO:0034185 IBA
    apolipoprotein binding GO:0034185 IDA
    apolipoprotein binding GO:0034185 ISS
    very-low-density lipoprotein particle binding GO:0034189 IDA
    cargo receptor activity GO:0038024 IDA
    reelin receptor activity GO:0038025 ISS
    calcium-dependent protein binding GO:0048306 IPI
Biological Process
    lipid transport GO:0006869 IEA
    receptor-mediated endocytosis GO:0006898 IDA
    signal transduction GO:0007165 TAS
    nervous system development GO:0007399 TAS
    memory GO:0007613 TAS
    cholesterol metabolic process GO:0008203 IEA
    ventral spinal cord development GO:0021517 IEA
    glycoprotein transport GO:0034436 IDA
    very-low-density lipoprotein particle clearance GO:0034447 IDA
    reelin-mediated signaling pathway GO:0038026 ISS
    dendrite morphogenesis GO:0048813 IEA
    regulation of synapse assembly GO:0051963 IEA
    positive regulation of dendrite development GO:1900006 ISS
Subcellular Localization
    lysosomal membrane GO:0005765 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    clathrin-coated pit GO:0005905 IEA
    membrane GO:0016020 IDA
    very-low-density lipoprotein particle GO:0034361 IEA
    receptor complex GO:0043235 IDA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified VLDLR in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VLDLR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MYLIP  
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
2 NDST2  
Affinity Capture-MS Homo sapiens
3 ZSCAN12  
Two-hybrid Homo sapiens
4 Clu  
Reconstituted Complex Mus musculus
Far Western Mus musculus
5 PDIA4 9601
Proximity Label-MS Homo sapiens
6 HPN  
Affinity Capture-MS Homo sapiens
7 TRIM66  
Affinity Capture-MS Homo sapiens
8 CUL3 8452
Affinity Capture-MS Homo sapiens
9 DAB1 1600
Two-hybrid Homo sapiens
10 LRRC4C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ANKRD36B  
Affinity Capture-MS Homo sapiens
12 CD36 948
Reconstituted Complex Homo sapiens
13 LRPAP1 4043
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SNX17 9784
Reconstituted Complex Homo sapiens
16 KIF23 9493
Affinity Capture-MS Homo sapiens
17 RELN 5649
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
18 ST14 6768
Affinity Capture-MS Homo sapiens
19 LPL 4023
Reconstituted Complex Homo sapiens
20 SYT2  
Affinity Capture-MS Homo sapiens
21 SEC61B 10952
Proximity Label-MS Homo sapiens
22 SYT1 6857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 IGFL3  
Affinity Capture-MS Homo sapiens
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