Gene description for SNX17
Gene name sorting nexin 17
Gene symbol SNX17
Other names/aliases -
Species Homo sapiens
 Database cross references - SNX17
ExoCarta ExoCarta_9784
Entrez Gene 9784
HGNC 14979
MIM 605963
UniProt Q15036  
 SNX17 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Thymus 23844026    
 Gene ontology annotations for SNX17
Molecular Function
    protein binding GO:0005515 IPI
    receptor binding GO:0005102 NAS
    phosphatidylinositol binding GO:0035091 IDA
    low-density lipoprotein particle receptor binding GO:0050750 IDA
    protein C-terminus binding GO:0008022 IPI
Biological Process
    signal transduction GO:0007165 IEA
    intracellular protein transport GO:0006886 NAS
    regulation of endocytosis GO:0030100 NAS
    endosomal transport GO:0016197 NAS
    cholesterol catabolic process GO:0006707 IC
    receptor-mediated endocytosis GO:0006898 IEA
Subcellular Localization
    cytoplasmic vesicle membrane GO:0030659 IEA
    cytoplasm GO:0005737 IDA
    early endosome GO:0005769 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    cytosol GO:0005829 IDA
    Golgi apparatus GO:0005794 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 IDA
    protein complex GO:0043234 IDA
    endosome membrane GO:0010008 IDA
    endosome GO:0005768 IDA
    membrane GO:0016020 NAS
 Experiment description of studies that identified SNX17 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SNX17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VLDLR  
Invivo Homo sapiens
Invitro Homo sapiens
2 LDLR 3949
Invitro Homo sapiens
Invivo Homo sapiens
3 LRP8  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
4 SELP 6403
Two-hybrid Homo sapiens
5 LRP1 4035
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SNX17 is involved
No pathways found





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