Gene description for SNX17
Gene name sorting nexin 17
Gene symbol SNX17
Other names/aliases -
Species Homo sapiens
 Database cross references - SNX17
ExoCarta ExoCarta_9784
Vesiclepedia VP_9784
Entrez Gene 9784
HGNC 14979
MIM 605963
UniProt Q15036  
 SNX17 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
 Gene ontology annotations for SNX17
Molecular Function
    signaling receptor binding GO:0005102 NAS
    protein binding GO:0005515 IPI
    phosphatidylinositol binding GO:0035091 IBA
    phosphatidylinositol binding GO:0035091 IDA
    low-density lipoprotein particle receptor binding GO:0050750 IDA
Biological Process
    kidney development GO:0001822 IEA
    cardiac septum development GO:0003279 IEA
    cholesterol catabolic process GO:0006707 IC
    intracellular protein transport GO:0006886 IBA
    intracellular protein transport GO:0006886 NAS
    receptor-mediated endocytosis GO:0006898 IEA
    signal transduction GO:0007165 IEA
    endosomal transport GO:0016197 NAS
    regulation of endocytosis GO:0030100 NAS
    endocytic recycling GO:0032456 IBA
    endocytic recycling GO:0032456 IMP
    aorta development GO:0035904 IEA
    coronary vasculature development GO:0060976 IEA
Subcellular Localization
    endosome GO:0005768 IDA
    early endosome GO:0005769 IBA
    early endosome GO:0005769 IDA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    endosome membrane GO:0010008 IDA
    membrane GO:0016020 NAS
    cytoplasmic vesicle GO:0031410 IDA
    protein-containing complex GO:0032991 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified SNX17 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SNX17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APOA1BP 128240
Affinity Capture-MS Homo sapiens
2 VLDLR 7436
Reconstituted Complex Homo sapiens
3 SELP 6403
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
4 GPRC5C 55890
Affinity Capture-MS Homo sapiens
5 MAP7 9053
Affinity Capture-MS Homo sapiens
6 SKIL  
Two-hybrid Homo sapiens
7 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 GMPR2 51292
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 RAB7A 7879
Proximity Label-MS Homo sapiens
10 COPZ2 51226
Affinity Capture-MS Homo sapiens
11 PITRM1 10531
Affinity Capture-MS Homo sapiens
12 XPO1 7514
Affinity Capture-MS Homo sapiens
13 SPATA6  
Affinity Capture-MS Homo sapiens
14 C1orf186  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
16 RLIM 51132
Two-hybrid Homo sapiens
17 PGM3 5238
Co-fractionation Homo sapiens
18 POLR3H  
Affinity Capture-MS Homo sapiens
19 FOXO1  
Affinity Capture-MS Homo sapiens
20 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SEZ6L  
Affinity Capture-MS Homo sapiens
22 INSR 3643
Affinity Capture-Western Homo sapiens
23 DAB2IP 153090
Affinity Capture-MS Homo sapiens
24 ATG9A 79065
Proximity Label-MS Homo sapiens
25 PBRM1 55193
Negative Genetic Homo sapiens
26 PARM1  
Affinity Capture-MS Homo sapiens
27 MRAP2  
Affinity Capture-MS Homo sapiens
28 NDUFB6 4712
Affinity Capture-MS Homo sapiens
29 DDX58 23586
Affinity Capture-RNA Homo sapiens
30 TSPAN3 10099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 APP 351
Protein-peptide Homo sapiens
32 PSD4  
Affinity Capture-MS Homo sapiens
33 NXF1 10482
Affinity Capture-RNA Homo sapiens
34 SEZ6  
Affinity Capture-MS Homo sapiens
35 LRP1 4035
Reconstituted Complex Homo sapiens
36 RAB5A 5868
Proximity Label-MS Homo sapiens
37 KCNE3  
Affinity Capture-MS Homo sapiens
38 DUSP1  
Affinity Capture-MS Homo sapiens
39 MOV10 4343
Affinity Capture-RNA Homo sapiens
40 RABAC1 10567
Two-hybrid Homo sapiens
41 HOXC8  
Affinity Capture-MS Homo sapiens
42 NTRK1 4914
Affinity Capture-Western Homo sapiens
43 NPDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 RIN1 9610
Two-hybrid Homo sapiens
45 LRP2 4036
Reconstituted Complex Homo sapiens
46 PAPSS2 9060
Co-fractionation Homo sapiens
47 RPA3 6119
Proximity Label-MS Homo sapiens
48 IL20RA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 UMPS 7372
Co-fractionation Homo sapiens
50 LDLR 3949
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
51 TMEM74  
Affinity Capture-MS Homo sapiens
52 RNF128  
Two-hybrid Homo sapiens
53 TPCN2  
Affinity Capture-MS Homo sapiens
54 SLC1A1 6505
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 MTM1 4534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 HAVCR2  
Affinity Capture-MS Homo sapiens
57 FRMD6 122786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 HRAS 3265
Reconstituted Complex Homo sapiens
59 VWC2L  
Affinity Capture-MS Homo sapiens
60 LRP8 7804
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SNX17 is involved
No pathways found





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