Gene description for RIN1
Gene name Ras and Rab interactor 1
Gene symbol RIN1
Other names/aliases -
Species Homo sapiens
 Database cross references - RIN1
ExoCarta ExoCarta_9610
Vesiclepedia VP_9610
Entrez Gene 9610
HGNC 18749
MIM 605965
UniProt Q13671  
 RIN1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RIN1
Molecular Function
    GTPase activator activity GO:0005096 IEA
    Ras GTPase binding GO:0017016 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of GTPase activity GO:0043547 IEA
    associative learning GO:0008306 IEA
    negative regulation of synaptic plasticity GO:0031914 IEA
    endocytosis GO:0006897 IEA
    memory GO:0007613 IEA
    signal transduction GO:0007165 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    cytoplasm GO:0005737 IDA
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified RIN1 in exosomes
1
Experiment ID 488
MISEV standards
EM
EV Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RIN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAE 7531
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
2 RRAS2 22800
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 HRAS 3265
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
4 YWHAZ 7534
Invitro Homo sapiens
5 ABL1 25
Invitro Homo sapiens
6 MLLT4 4301
Two-hybrid Homo sapiens
7 RAB5B 5869
Two-hybrid Homo sapiens
8 RALGDS  
Two-hybrid Homo sapiens
9 RAB5A 5868
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
10 YWHAB 7529
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RIN1 is involved
No pathways found





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