Gene description for DCTN3
Gene name dynactin 3 (p22)
Gene symbol DCTN3
Other names/aliases DCTN-22
DCTN22
Species Homo sapiens
 Database cross references - DCTN3
ExoCarta ExoCarta_11258
Entrez Gene 11258
HGNC 2713
MIM 607387
UniProt O75935  
 DCTN3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for DCTN3
Molecular Function
    structural molecule activity GO:0005198 TAS
    protein binding GO:0005515 IPI
Biological Process
    mitotic cell cycle GO:0000278 TAS
    G2/M transition of mitotic cell cycle GO:0000086 TAS
    microtubule-based process GO:0007017 IEA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
    cytokinesis GO:0000910 IDA
    organelle organization GO:0006996 TAS
    mitotic nuclear division GO:0007067 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    spindle GO:0005819 IEA
    condensed chromosome kinetochore GO:0000777 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
    midbody GO:0030496 IEA
    dynactin complex GO:0005869 IPI
    cleavage furrow GO:0032154 IEA
    centrosome GO:0005813 IDA
 Experiment description of studies that identified DCTN3 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DCTN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PBX2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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