Gene description for Dctn2
Gene name dynactin 2
Gene symbol Dctn2
Other names/aliases 2310042E05Rik
C130077D06Rik
C87049
DCTN-50
GMP23-48K
RBP50
p50
Species Mus musculus
 Database cross references - Dctn2
ExoCarta ExoCarta_69654
Vesiclepedia VP_69654
Entrez Gene 69654
UniProt Q99KJ8  
 Dctn2 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Dctn2
Molecular Function
    spectrin binding GO:0030507 ISO
    protein binding GO:0005515 IPI
    motor activity GO:0003774 IEA
Biological Process
    microtubule-based process GO:0007017 IEA
    cell proliferation GO:0008283 ISO
    mitotic spindle organization GO:0007052 ISO
    mitotic nuclear division GO:0007067 ISO
    melanosome transport GO:0032402 IMP
Subcellular Localization
    growth cone GO:0030426 IDA
    cytoskeleton GO:0005856 IEA
    vesicle GO:0031982 ISO
    centrosome GO:0005813 ISO
    kinetochore GO:0000776 ISO
    dynactin complex GO:0005869 ISO
    cell GO:0005623 IMP
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 IEA
    dynein complex GO:0030286 IEA
    microtubule GO:0005874 IEA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Dctn2 in exosomes
1
Experiment ID 210
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD81|FLOT1
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Dctn2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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