Gene description for KLHL2
Gene name kelch-like family member 2
Gene symbol KLHL2
Other names/aliases ABP-KELCH
Species Homo sapiens
 Database cross references - KLHL2
ExoCarta ExoCarta_11275
Entrez Gene 11275
HGNC 6353
MIM 605774
UniProt O95198  
 KLHL2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for KLHL2
Molecular Function
    protein binding GO:0005515 IPI
    actin binding GO:0003779 IDA
Biological Process
    protein ubiquitination GO:0016567 ISS
Subcellular Localization
    Cul3-RING ubiquitin ligase complex GO:0031463 ISS
    lamellipodium GO:0030027 IEA
    cytoplasm GO:0005737 ISS
    actin cytoskeleton GO:0015629 IDA
    cytosol GO:0005829 IEA
    ruffle GO:0001726 IEA
 Experiment description of studies that identified KLHL2 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KLHL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLHL12  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which KLHL2 is involved
No pathways found

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