Gene description for POLR3C
Gene name polymerase (RNA) III (DNA directed) polypeptide C (62kD)
Gene symbol POLR3C
Other names/aliases RPC3
RPC62
Species Homo sapiens
 Database cross references - POLR3C
ExoCarta ExoCarta_10623
Entrez Gene 10623
HGNC 30076
UniProt Q9BUI4  
 POLR3C identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for POLR3C
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase III activity GO:0001056 IBA
    DNA-directed RNA polymerase activity GO:0003899 TAS
    DNA binding GO:0003677 IEA
Biological Process
    gene expression GO:0010467 TAS
    defense response to virus GO:0051607 IEA
    positive regulation of innate immune response GO:0045089 IMP
    regulation of transcription from RNA polymerase III promoter GO:0006359 TAS
    positive regulation of type I interferon production GO:0032481 TAS
    innate immune response GO:0045087 TAS
    transcription from RNA polymerase III promoter GO:0006383 TAS
    positive regulation of interferon-beta production GO:0032728 IMP
    termination of RNA polymerase III transcription GO:0006386 TAS
    transcription elongation from RNA polymerase III promoter GO:0006385 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 TAS
    DNA-directed RNA polymerase III complex GO:0005666 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified POLR3C in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for POLR3C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTF3C1  
Affinity Capture-Western Homo sapiens
2 POLR3F  
Invivo Homo sapiens
3 GTF3C5 9328
Affinity Capture-Western Homo sapiens
4 GTF3C3  
Affinity Capture-Western Homo sapiens
5 GTF3C4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
6 GTF3C2  
Affinity Capture-Western Homo sapiens
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