Gene description for SNRNP40
Gene name small nuclear ribonucleoprotein 40kDa (U5)
Gene symbol SNRNP40
Other names/aliases 40K
HPRP8BP
PRP8BP
PRPF8BP
SPF38
WDR57
Species Homo sapiens
 Database cross references - SNRNP40
ExoCarta ExoCarta_9410
Entrez Gene 9410
HGNC 30857
MIM 607797
UniProt Q96DI7  
 SNRNP40 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for SNRNP40
Molecular Function
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    RNA splicing GO:0008380 TAS
    RNA splicing, via transesterification reactions GO:0000375 TAS
    gene expression GO:0010467 TAS
    mRNA splicing, via spliceosome GO:0000398 TAS
    RNA processing GO:0006396 TAS
Subcellular Localization
    catalytic step 2 spliceosome GO:0071013 IDA
    small nucleolar ribonucleoprotein complex GO:0005732 NAS
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 TAS
    U5 snRNP GO:0005682 TAS
 Experiment description of studies that identified SNRNP40 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SNRNP40
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNRPB2 6629
Affinity Capture-MS Homo sapiens
2 CD2BP2 10421
Affinity Capture-MS Homo sapiens
3 PRPF6 24148
Affinity Capture-MS Homo sapiens
4 MAGEA6  
Affinity Capture-MS Homo sapiens
5 EFTUD2 9343
Affinity Capture-MS Homo sapiens
6 SNRNP200 23020
Affinity Capture-MS Homo sapiens
7 PFDN2 5202
Affinity Capture-MS Homo sapiens
8 PRPF8 10594
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
9 DDR1 780
Two-hybrid Homo sapiens
10 SF3B1 23451
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SNRNP40 is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway TAS Reactome
mRNA Splicing - Minor Pathway TAS Reactome





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