Gene description for NCDN
Gene name neurochondrin
Gene symbol NCDN
Other names/aliases -
Species Homo sapiens
 Database cross references - NCDN
ExoCarta ExoCarta_23154
Vesiclepedia VP_23154
Entrez Gene 23154
HGNC 17597
MIM 608458
UniProt Q9UBB6  
 NCDN identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NCDN
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    neuron projection development GO:0031175 IBA
    neuron projection development GO:0031175 ISS
    bone resorption GO:0045453 IEA
    regulation of neuronal synaptic plasticity GO:0048168 IBA
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IEA
Subcellular Localization
    nucleus GO:0005634 ISS
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISS
    endosome membrane GO:0010008 IEA
    membrane GO:0016020 HDA
    membrane GO:0016020 IDA
    axon GO:0030424 ISS
    dendrite GO:0030425 IBA
    dendrite GO:0030425 ISS
    neuronal cell body GO:0043025 ISS
    perikaryon GO:0043204 IEA
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified NCDN in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NCDN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POT1  
Two-hybrid Homo sapiens
2 CIB2  
Affinity Capture-MS Homo sapiens
3 AES 166
Two-hybrid Homo sapiens
4 ZNHIT2 741
Affinity Capture-MS Homo sapiens
5 C9orf78 51759
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 UBC 7316
Affinity Capture-MS Homo sapiens
7 AAR2 25980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SNRPF 6636
Affinity Capture-MS Homo sapiens
9 HSD17B12 51144
Affinity Capture-MS Homo sapiens
10 SNRPD2 6633
Affinity Capture-MS Homo sapiens
11 RUVBL1 8607
Affinity Capture-MS Homo sapiens
12 IGSF8 93185
Affinity Capture-MS Homo sapiens
13 RFXANK  
Affinity Capture-MS Homo sapiens
14 CCDC8  
Affinity Capture-MS Homo sapiens
15 TINF2  
Two-hybrid Homo sapiens
16 HMGA1 3159
Affinity Capture-MS Homo sapiens
17 GINS4  
Co-fractionation Homo sapiens
18 DNAJC7 7266
Proximity Label-MS Homo sapiens
19 Prpf8 192159
Affinity Capture-MS Mus musculus
20 NPAS1  
Affinity Capture-MS Homo sapiens
21 KIAA1715 80856
Affinity Capture-MS Homo sapiens
22 CD70 970
Affinity Capture-MS Homo sapiens
23 ATP5A1 498
Affinity Capture-MS Homo sapiens
24 SLC1A5 6510
Affinity Capture-MS Homo sapiens
25 PRPF8 10594
Proximity Label-MS Homo sapiens
26 LRIT3  
Affinity Capture-MS Homo sapiens
27 KLHL34  
Affinity Capture-MS Homo sapiens
28 A2M 2
Two-hybrid Homo sapiens
29 ILVBL 10994
Affinity Capture-MS Homo sapiens
30 COMTD1 118881
Affinity Capture-MS Homo sapiens
31 VCP 7415
Affinity Capture-MS Homo sapiens
32 NT5C 30833
Affinity Capture-MS Homo sapiens
33 MOGS 7841
Affinity Capture-MS Homo sapiens
34 BICD2 23299
Proximity Label-MS Homo sapiens
35 RPN1 6184
Affinity Capture-MS Homo sapiens
36 LYST 1130
Two-hybrid Homo sapiens
37 AGPS 8540
Affinity Capture-MS Homo sapiens
38 DNAJB5  
Proximity Label-MS Homo sapiens
39 COA1  
Affinity Capture-MS Homo sapiens
40 ATP5B 506
Affinity Capture-MS Homo sapiens
41 UBXN6 80700
Affinity Capture-MS Homo sapiens
42 ACD  
Two-hybrid Homo sapiens
43 CD40 958
Affinity Capture-MS Homo sapiens
44 TUBB 203068
Affinity Capture-MS Homo sapiens
45 GRM5  
Affinity Capture-Western Homo sapiens
46 BTNL9  
Affinity Capture-MS Homo sapiens
47 ECD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 XPO1 7514
Affinity Capture-MS Homo sapiens
49 PINK1  
Affinity Capture-MS Homo sapiens
50 ASAH1 427
Affinity Capture-MS Homo sapiens
51 PTPRA 5786
Affinity Capture-MS Homo sapiens
52 PRCP 5547
Co-fractionation Homo sapiens
53 ZNF252P-AS1  
Affinity Capture-MS Homo sapiens
54 EGFR 1956
Affinity Capture-MS Homo sapiens
55 TSSC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 NCDN 23154
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 EFTUD2 9343
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 KIAA1143  
Affinity Capture-MS Homo sapiens
59 C12orf74  
Affinity Capture-MS Homo sapiens
60 RPA3 6119
Proximity Label-MS Homo sapiens
61 SOHLH1  
Affinity Capture-MS Homo sapiens
62 PTPRN  
Affinity Capture-MS Homo sapiens
63 HUWE1 10075
Affinity Capture-MS Homo sapiens
64 GYPA  
Affinity Capture-MS Homo sapiens
65 ALDH3A2 224
Affinity Capture-MS Homo sapiens
66 EAPP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 EFHC2  
Two-hybrid Homo sapiens
68 PGRMC1 10857
Affinity Capture-MS Homo sapiens
69 TTC27 55622
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 RUVBL2 10856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 EHHADH 1962
Affinity Capture-MS Homo sapiens
72 PDHA1 5160
Co-fractionation Homo sapiens
73 PLOD1 5351
Co-fractionation Homo sapiens
74 HTR6  
Affinity Capture-MS Homo sapiens
75 SNRNP40 9410
Affinity Capture-MS Homo sapiens
76 PPP1R2 5504
Co-fractionation Homo sapiens
77 SPN 6693
Affinity Capture-MS Homo sapiens
78 GOLGA5 9950
Affinity Capture-MS Homo sapiens
79 C16orf72 29035
Affinity Capture-MS Homo sapiens
80 ATP1A1 476
Affinity Capture-MS Homo sapiens
81 FAM50A 9130
Affinity Capture-MS Homo sapiens
82 IGF2R 3482
Affinity Capture-MS Homo sapiens
83 PTGES3 10728
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 CLPTM1L 81037
Affinity Capture-MS Homo sapiens
85 DNAJC17  
Affinity Capture-MS Homo sapiens
86 GGT1 2678
Affinity Capture-MS Homo sapiens
87 ASL 435
Co-fractionation Homo sapiens
88 ESYT1 23344
Affinity Capture-MS Homo sapiens
89 SEC61A1 29927
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NCDN is involved
No pathways found





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