Gene description for PDZD8
Gene name PDZ domain containing 8
Gene symbol PDZD8
Other names/aliases PDZK8
Species Homo sapiens
 Database cross references - PDZD8
ExoCarta ExoCarta_118987
Entrez Gene 118987
HGNC 26974
MIM 614235
UniProt Q8NEN9  
 PDZD8 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for PDZD8
Molecular Function
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of cell morphogenesis GO:0022604 IMP
    viral process GO:0016032 IEA
    cytoskeleton organization GO:0007010 IMP
    intracellular signal transduction GO:0035556 IEA
Subcellular Localization
    intracellular GO:0005622 IEA
    membrane GO:0016020 IDA
 Experiment description of studies that identified PDZD8 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for PDZD8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PDZD8 is involved
No pathways found





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