Gene description for PDZD8
Gene name PDZ domain containing 8
Gene symbol PDZD8
Other names/aliases PDZK8
Species Homo sapiens
 Database cross references - PDZD8
ExoCarta ExoCarta_118987
Vesiclepedia VP_118987
Entrez Gene 118987
HGNC 26974
MIM 614235
UniProt Q8NEN9  
 PDZD8 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Endothelial cells 26027894    
 Gene ontology annotations for PDZD8
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    lipid transport GO:0006869 IEA
    cytoskeleton organization GO:0007010 IMP
    regulation of cell morphogenesis GO:0022604 IMP
    mitochondrial calcium ion homeostasis GO:0051560 IBA
    mitochondrial calcium ion homeostasis GO:0051560 IDA
    mitochondrion-endoplasmic reticulum membrane tethering GO:1990456 IBA
    mitochondrion-endoplasmic reticulum membrane tethering GO:1990456 IDA
Subcellular Localization
    mitochondrion GO:0005739 IEA
    endoplasmic reticulum membrane GO:0005789 IDA
    membrane GO:0016020 HDA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 IBA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 IDA
 Experiment description of studies that identified PDZD8 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for PDZD8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPSA 3921
Affinity Capture-MS Homo sapiens
2 EIF3A 8661
Affinity Capture-MS Homo sapiens
3 HSD17B11 51170
Proximity Label-MS Homo sapiens
4 RPS3A 6189
Affinity Capture-MS Homo sapiens
5 PSMD6 9861
Affinity Capture-MS Homo sapiens
6 PCDHGA5  
Affinity Capture-MS Homo sapiens
7 METTL7A 25840
Proximity Label-MS Homo sapiens
8 LAMP3  
Proximity Label-MS Homo sapiens
9 RPL30 6156
Affinity Capture-MS Homo sapiens
10 GJA1 2697
Proximity Label-MS Homo sapiens
11 SRPRB 58477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CDH5  
Affinity Capture-MS Homo sapiens
13 NACA 4666
Affinity Capture-MS Homo sapiens
14 PCDHGB4 8641
Affinity Capture-MS Homo sapiens
15 CTDNEP1 23399
Proximity Label-MS Homo sapiens
16 RPL37A 6168
Affinity Capture-MS Homo sapiens
17 RPL9 6133
Affinity Capture-MS Homo sapiens
18 RPL10 6134
Affinity Capture-MS Homo sapiens
19 KIF20A 10112
Affinity Capture-MS Homo sapiens
20 SNRNP40 9410
Affinity Capture-MS Homo sapiens
21 SEC63 11231
Proximity Label-MS Homo sapiens
22 LAMP2 3920
Proximity Label-MS Homo sapiens
23 DNAJC25 548645
Proximity Label-MS Homo sapiens
24 PTPN1 5770
Proximity Label-MS Homo sapiens
25 FSHR  
Affinity Capture-MS Homo sapiens
26 ST7  
Proximity Label-MS Homo sapiens
27 YTHDF2 51441
Affinity Capture-MS Homo sapiens
28 HIST2H2AA3 8337
Affinity Capture-MS Homo sapiens
29 KIAA1429 25962
Affinity Capture-RNA Homo sapiens
30 RPL10A 4736
Affinity Capture-MS Homo sapiens
31 TEX264 51368
Affinity Capture-MS Homo sapiens
32 B3GAT1  
Proximity Label-MS Homo sapiens
33 BTN2A1 11120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 H1FX 8971
Affinity Capture-MS Homo sapiens
35 HDLBP 3069
Affinity Capture-MS Homo sapiens
36 EIF3B 8662
Affinity Capture-MS Homo sapiens
37 RAB3B 5865
Proximity Label-MS Homo sapiens
38 RPL24 6152
Affinity Capture-MS Homo sapiens
39 TREML2 79865
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 RPS8 6202
Affinity Capture-MS Homo sapiens
41 PSMC6 5706
Affinity Capture-MS Homo sapiens
42 TMEM17  
Proximity Label-MS Homo sapiens
43 GJD3  
Proximity Label-MS Homo sapiens
44 DNAJC16  
Proximity Label-MS Homo sapiens
45 SLC25A46 91137
Proximity Label-MS Homo sapiens
46 CHMP4A 29082
Affinity Capture-MS Homo sapiens
47 PXMP2  
Proximity Label-MS Homo sapiens
48 RAB35 11021
Proximity Label-MS Homo sapiens
49 PABPC4 8761
Affinity Capture-MS Homo sapiens
50 RPL19 6143
Affinity Capture-MS Homo sapiens
51 MARCKS 4082
Proximity Label-MS Homo sapiens
52 LAMTOR1 55004
Proximity Label-MS Homo sapiens
53 LMAN1 3998
Proximity Label-MS Homo sapiens
54 NUP155 9631
Proximity Label-MS Homo sapiens
55 KIAA1715 80856
Proximity Label-MS Homo sapiens
56 DNAJC14  
Proximity Label-MS Homo sapiens
57 RAB5A 5868
Proximity Label-MS Homo sapiens
58 RPL27 6155
Affinity Capture-MS Homo sapiens
59 NUMA1 4926
Affinity Capture-MS Homo sapiens
60 EMD 2010
Proximity Label-MS Homo sapiens
61 RARS 5917
Affinity Capture-MS Homo sapiens
62 RPS28 6234
Affinity Capture-MS Homo sapiens
63 CXADR 1525
Proximity Label-MS Homo sapiens
64 NUP50 10762
Affinity Capture-MS Homo sapiens
65 FAM189B  
Affinity Capture-MS Homo sapiens
66 MARS 4141
Affinity Capture-MS Homo sapiens
67 GABRA6  
Affinity Capture-MS Homo sapiens
68 PCDHB11  
Affinity Capture-MS Homo sapiens
69 RPL18A 6142
Affinity Capture-MS Homo sapiens
70 PFDN2 5202
Affinity Capture-MS Homo sapiens
71 FUBP1 8880
Affinity Capture-MS Homo sapiens
72 BARD1 580
Two-hybrid Homo sapiens
73 DDX5 1655
Affinity Capture-MS Homo sapiens
74 GNL3 26354
Affinity Capture-MS Homo sapiens
75 RPL31 6160
Affinity Capture-MS Homo sapiens
76 DHX9 1660
Affinity Capture-MS Homo sapiens
77 HIST1H1E 3008
Proximity Label-MS Homo sapiens
78 LAMP1 3916
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
79 PEX14 5195
Proximity Label-MS Homo sapiens
80 RPL36 25873
Affinity Capture-MS Homo sapiens
81 KIF11 3832
Affinity Capture-MS Homo sapiens
82 HIST1H1C 3006
Proximity Label-MS Homo sapiens
83 RPL27A 6157
Affinity Capture-MS Homo sapiens
84 DHFRL1  
Proximity Label-MS Homo sapiens
85 ALYREF 10189
Affinity Capture-MS Homo sapiens
86 PABPN1 8106
Affinity Capture-MS Homo sapiens
87 IL17RC 84818
Affinity Capture-MS Homo sapiens
88 DDX17 10521
Affinity Capture-MS Homo sapiens
89 RPS16 6217
Affinity Capture-MS Homo sapiens
90 DDX39B 7919
Affinity Capture-MS Homo sapiens
91 RHOT2 89941
Proximity Label-MS Homo sapiens
92 ELOVL5 60481
Proximity Label-MS Homo sapiens
93 ENAH 55740
Affinity Capture-MS Homo sapiens
94 SEC61B 10952
Proximity Label-MS Homo sapiens
95 RPL29 6159
Affinity Capture-MS Homo sapiens
96 CHRND  
Affinity Capture-MS Homo sapiens
97 STAM 8027
Affinity Capture-MS Homo sapiens
98 RPL11 6135
Affinity Capture-MS Homo sapiens
99 KCNS3 3790
Affinity Capture-MS Homo sapiens
100 RHBDD1 84236
Proximity Label-MS Homo sapiens
101 RPL32 6161
Affinity Capture-MS Homo sapiens
102 PCDHB7  
Affinity Capture-MS Homo sapiens
103 MAP4 4134
Affinity Capture-MS Homo sapiens
104 CANX 821
Proximity Label-MS Homo sapiens
105 RPL23 9349
Affinity Capture-MS Homo sapiens
106 LRRC59 55379
Proximity Label-MS Homo sapiens
107 PANX1 24145
Proximity Label-MS Homo sapiens
108 EIF4G1 1981
Affinity Capture-MS Homo sapiens
109 RPS20 6224
Affinity Capture-MS Homo sapiens
110 UBQLN2 29978
Affinity Capture-MS Homo sapiens
111 TMPRSS3  
Affinity Capture-MS Homo sapiens
112 TMEM9B 56674
Affinity Capture-MS Homo sapiens
113 LRRTM1 347730
Affinity Capture-MS Homo sapiens
114 BCAP31 10134
Proximity Label-MS Homo sapiens
115 HSD3B7 80270
Proximity Label-MS Homo sapiens
116 RPS7 6201
Affinity Capture-MS Homo sapiens
117 KARS 3735
Affinity Capture-MS Homo sapiens
118 FKBP8 23770
Proximity Label-MS Homo sapiens
119 ARF6 382
Proximity Label-MS Homo sapiens
120 EIF4A1 1973
Affinity Capture-MS Homo sapiens
121 RPL7 6129
Affinity Capture-MS Homo sapiens
122 PSMD7 5713
Affinity Capture-MS Homo sapiens
123 LARS 51520
Affinity Capture-MS Homo sapiens
124 EFTUD2 9343
Affinity Capture-MS Homo sapiens
125 PRKACA 5566
Proximity Label-MS Homo sapiens
126 CHRNA9  
Affinity Capture-MS Homo sapiens
127 ATP2A1 487
Proximity Label-MS Homo sapiens
128 RAB9A 9367
Proximity Label-MS Homo sapiens
129 RPL35A 6165
Affinity Capture-MS Homo sapiens
130 EIF3CL 728689
Affinity Capture-MS Homo sapiens
131 CCDC124 115098
Affinity Capture-MS Homo sapiens
132 MATR3 9782
Affinity Capture-MS Homo sapiens
133 RPL23A 6147
Affinity Capture-MS Homo sapiens
134 RPL18 6141
Affinity Capture-MS Homo sapiens
135 KTN1 3895
Affinity Capture-MS Homo sapiens
136 RPS18 6222
Affinity Capture-MS Homo sapiens
137 CYP2C9  
Proximity Label-MS Homo sapiens
138 RAB5C 5878
Proximity Label-MS Homo sapiens
139 PRPS1L1 221823
Affinity Capture-MS Homo sapiens
140 EIF3H 8667
Affinity Capture-MS Homo sapiens
141 RPL15 6138
Affinity Capture-MS Homo sapiens
142 PCDHAC2  
Affinity Capture-MS Homo sapiens
143 AIMP1 9255
Affinity Capture-MS Homo sapiens
144 RPL13 6137
Affinity Capture-MS Homo sapiens
145 SPAG9 9043
Affinity Capture-MS Homo sapiens
146 RBM8A 9939
Affinity Capture-MS Homo sapiens
147 RPS25 6230
Affinity Capture-MS Homo sapiens
148 EIF3C 8663
Affinity Capture-MS Homo sapiens
149 ILF3 3609
Affinity Capture-MS Homo sapiens
150 RPL6 6128
Affinity Capture-MS Homo sapiens
151 EIF3I 8668
Affinity Capture-MS Homo sapiens
152 ASIC4  
Affinity Capture-MS Homo sapiens
153 KCNC4  
Affinity Capture-MS Homo sapiens
154 CDC37 11140
Affinity Capture-MS Homo sapiens
155 MAP1LC3B 81631
Affinity Capture-MS Homo sapiens
156 RBMX 27316
Affinity Capture-MS Homo sapiens
157 HNRNPM 4670
Affinity Capture-MS Homo sapiens
158 RPS4X 6191
Affinity Capture-MS Homo sapiens
159 THRAP3 9967
Affinity Capture-MS Homo sapiens
160 DCTN2 10540
Affinity Capture-MS Homo sapiens
161 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
162 TMEM216  
Proximity Label-MS Homo sapiens
163 ERGIC1 57222
Proximity Label-MS Homo sapiens
164 HIST1H1B 3009
Proximity Label-MS Homo sapiens
165 RPS15A 6210
Affinity Capture-MS Homo sapiens
166 HNRNPK 3190
Affinity Capture-MS Homo sapiens
167 RAB4A 5867
Proximity Label-MS Homo sapiens
168 RPS26 6231
Affinity Capture-MS Homo sapiens
169 EVA1C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 RPL39 6170
Affinity Capture-MS Homo sapiens
171 ERGIC2 51290
Proximity Label-MS Homo sapiens
172 RPL38 6169
Affinity Capture-MS Homo sapiens
173 RPS24 6229
Affinity Capture-MS Homo sapiens
174 NMUR2  
Affinity Capture-MS Homo sapiens
175 RPS23 6228
Affinity Capture-MS Homo sapiens
176 FIS1 51024
Proximity Label-MS Homo sapiens
177 ZNRF4  
Affinity Capture-MS Homo sapiens
178 RPL7A 6130
Affinity Capture-MS Homo sapiens
179 RAB11A 8766
Proximity Label-MS Homo sapiens
180 RPS6 6194
Affinity Capture-MS Homo sapiens
181 RPL8 6132
Affinity Capture-MS Homo sapiens
182 CNGA3  
Affinity Capture-MS Homo sapiens
183 FAM189A2  
Affinity Capture-MS Homo sapiens
184 PCDHB16  
Affinity Capture-MS Homo sapiens
185 PRRC2C 23215
Affinity Capture-MS Homo sapiens
186 DNAJC1 64215
Proximity Label-MS Homo sapiens
187 KRAS 3845
Proximity Label-MS Homo sapiens
188 PAIP2  
Proximity Label-MS Homo sapiens
189 CKAP4 10970
Proximity Label-MS Homo sapiens
190 PRMT1 3276
Affinity Capture-MS Homo sapiens
191 EIF3L 51386
Affinity Capture-MS Homo sapiens
192 RPL17 6139
Affinity Capture-MS Homo sapiens
193 DERL1 79139
Proximity Label-MS Homo sapiens
194 ENTPD4 9583
Affinity Capture-MS Homo sapiens
195 RPS13 6207
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PDZD8 is involved
No pathways found





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