Gene description for RET
Gene name	ret proto-oncogene
Gene symbol	RET
Other names/aliases	CDHF12 CDHR16 HSCR1 MEN2A MEN2B MTC1 PTC RET-ELE1 RET51
Species	Homo sapiens
Database cross references - RET
ExoCarta	ExoCarta_5979
Vesiclepedia	VP_5979
Entrez Gene	5979
HGNC	9967
MIM	164761
UniProt	P07949
RET identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for RET

Molecular Function     protein tyrosine kinase activity GO:0004713 TAS     transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA     transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA     transmembrane receptor protein tyrosine kinase activity GO:0004714 TAS     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IEA     fibroblast growth factor receptor activity GO:0005007 IEA     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     calcium ion binding GO:0005509 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     boss receptor activity GO:0008288 IEA     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     signaling receptor activity GO:0038023 TAS     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     MAPK cascade GO:0000165 IEA     ureteric bud development GO:0001657 IEA     neural crest cell migration GO:0001755 IEA     embryonic epithelial tube formation GO:0001838 IEA     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 TAS     homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA     neuron cell-cell adhesion GO:0007158 IMP     signal transduction GO:0007165 TAS     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     epidermal growth factor receptor signaling pathway GO:0007173 IEA     multicellular organism development GO:0007275 IBA     axon guidance GO:0007411 TAS     posterior midgut development GO:0007497 TAS     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IEA     response to xenobiotic stimulus GO:0009410 IEA     positive regulation of gene expression GO:0010628 IEA     positive regulation of neuron projection development GO:0010976 IMP     positive regulation of neuron maturation GO:0014042 IEA     regulation of cell adhesion GO:0030155 IDA     positive regulation of cell migration GO:0030335 IDA     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     membrane protein proteolysis GO:0033619 IDA     positive regulation of cell adhesion mediated by integrin GO:0033630 IDA     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     ureter maturation GO:0035799 IEA     glial cell-derived neurotrophic factor receptor signaling pathway GO:0035860 IDA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     neuron maturation GO:0042551 IEA     positive regulation of MAPK cascade GO:0043410 IDA     positive regulation of MAPK cascade GO:0043410 IMP     positive regulation of cell size GO:0045793 IEA     positive regulation of DNA-templated transcription GO:0045893 ISS     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     response to pain GO:0048265 ISS     enteric nervous system development GO:0048484 IEA     regulation of axonogenesis GO:0050770 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP     retina development in camera-type eye GO:0060041 IEA     innervation GO:0060384 IEA     Peyer's patch morphogenesis GO:0061146 ISS     cellular response to retinoic acid GO:0071300 IMP     positive regulation of metanephric glomerulus development GO:0072300 ISS     lymphocyte migration into lymphoid organs GO:0097021 ISS     GDF15-GFRAL signaling pathway GO:0160144 IDA     positive regulation of cysteine-type endopeptidase activity GO:2001056 IMP     positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IMP     positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 TAS Subcellular Localization     early endosome GO:0005769 IEA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     endosome membrane GO:0010008 IDA     axon GO:0030424 IBA     dendrite GO:0030425 IEA     neuronal cell body GO:0043025 IEA     receptor complex GO:0043235 IBA     receptor complex GO:0043235 IDA     plasma membrane protein complex GO:0098797 IDA