Gene description for RET
Gene name ret proto-oncogene
Gene symbol RET
Other names/aliases CDHF12
CDHR16
HSCR1
MEN2A
MEN2B
MTC1
PTC
RET-ELE1
RET51
Species Homo sapiens
 Database cross references - RET
ExoCarta ExoCarta_5979
Vesiclepedia VP_5979
Entrez Gene 5979
HGNC 9967
MIM 164761
UniProt P07949  
 RET identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for RET
Molecular Function
    protein binding GO:0005515 IPI
    receptor activity GO:0004872 TAS
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA
    protein tyrosine kinase activity GO:0004713 TAS
    ATP binding GO:0005524 IEA
    calcium ion binding GO:0005509 IDA
Biological Process
    signal transduction GO:0007165 TAS
    positive regulation of cell size GO:0045793 IEA
    positive regulation of neuron projection development GO:0010976 IMP
    lymphocyte migration into lymphoid organs GO:0097021 ISS
    neuron cell-cell adhesion GO:0007158 IMP
    innervation GO:0060384 IEA
    retina development in camera-type eye GO:0060041 IEA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    ureter maturation GO:0035799 IEA
    ureteric bud development GO:0001657 IEA
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 TAS
    neuron maturation GO:0042551 IEA
    neural crest cell migration GO:0001755 IEA
    positive regulation of metanephric glomerulus development GO:0072300 ISS
    membrane protein proteolysis GO:0033619 IDA
    MAPK cascade GO:0000165 IEA
    regulation of axonogenesis GO:0050770 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 TAS
    cellular response to retinoic acid GO:0071300 IMP
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    response to pain GO:0048265 ISS
    positive regulation of cell migration GO:0030335 IDA
    posterior midgut development GO:0007497 TAS
    enteric nervous system development GO:0048484 IEA
    protein phosphorylation GO:0006468 TAS
    positive regulation of neuron maturation GO:0014042 IEA
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IMP
    positive regulation of transcription, DNA-templated GO:0045893 ISS
    regulation of cell adhesion GO:0030155 IDA
    response to drug GO:0042493 IEA
    embryonic epithelial tube formation GO:0001838 IEA
    positive regulation of cell adhesion mediated by integrin GO:0033630 IDA
    Peyer's patch morphogenesis GO:0061146 ISS
Subcellular Localization
    membrane raft GO:0045121 IEA
    receptor complex GO:0043235 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    integral component of plasma membrane GO:0005887 IDA
    endosome membrane GO:0010008 IDA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified RET in exosomes
1
Experiment ID 224
MISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101|CD63|CD81
EV Enriched markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for RET
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DOK5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 GAB1  
Invivo Homo sapiens
3 CRK 1398
Reconstituted Complex Homo sapiens
4 GRB7 2886
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
5 SRC 6714
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
6 PDLIM7 9260
Invivo Homo sapiens
7 DOK2 9046
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
8 DOK1 1796
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
9 DOK4 55715
Affinity Capture-Western Homo sapiens
10 DOK6  
Affinity Capture-Western Homo sapiens
11 GDNF  
Invivo Homo sapiens
Invivo Homo sapiens
12 PLCG1 5335
Invivo Homo sapiens
Invitro Homo sapiens
13 GRB2 2885
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
14 SHC1 6464
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
15 GRB10 2887
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
16 FRS2 10818
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
17 STAT3 6774
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 NRTN  
Invivo Homo sapiens
19 PTPRF 5792
Reconstituted Complex Homo sapiens
20 GFRA1 2674
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RET is involved
No pathways found





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