Gene description for SHC1
Gene name	SHC (Src homology 2 domain containing) transforming protein 1
Gene symbol	SHC1
Other names/aliases	SHC SHCA
Species	Homo sapiens
Database cross references - SHC1
ExoCarta	ExoCarta_6464
Entrez Gene	6464
HGNC	10840
MIM	600560
UniProt	P29353
SHC1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Prostate cancer cells	25844599

Gene ontology annotations for SHC1

Molecular Function     insulin-like growth factor receptor binding GO:0005159 IPI     insulin receptor binding GO:0005158 IPI     ephrin receptor binding GO:0046875 IPI     protein tyrosine kinase activity GO:0004713 TAS     phospholipid binding GO:0005543 TAS     transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 TAS     epidermal growth factor receptor binding GO:0005154 ISS     neurotrophin TRKA receptor binding GO:0005168 IPI     protein kinase binding GO:0019901 IBA     protein binding GO:0005515 IPI Biological Process     activation of MAPK activity GO:0000187 IDA     regulation of growth GO:0040008 IEA     actin cytoskeleton reorganization GO:0031532 IEA     regulation of epidermal growth factor-activated receptor activity GO:0007176 TAS     single organismal cell-cell adhesion GO:0016337 IEA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     insulin receptor signaling pathway GO:0008286 TAS     Ras protein signal transduction GO:0007265 TAS     platelet activation GO:0030168 TAS     IRE1-mediated unfolded protein response GO:0036498 TAS     angiogenesis GO:0001525 IEA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     heart development GO:0007507 IEA     innate immune response GO:0045087 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     leukocyte migration GO:0050900 TAS     cellular protein metabolic process GO:0044267 TAS     peptidyl-tyrosine phosphorylation GO:0018108 TAS     MAPK cascade GO:0000165 IDA     blood coagulation GO:0007596 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     endoplasmic reticulum unfolded protein response GO:0030968 TAS     viral process GO:0016032 IEA     positive regulation of DNA replication GO:0045740 ISS     positive regulation of cell proliferation GO:0008284 NAS Subcellular Localization     mitochondrial matrix GO:0005759 IEA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 TAS     Shc-EGFR complex GO:0070435 ISS