Gene description for PSPH
Gene name phosphoserine phosphatase
Gene symbol PSPH
Other names/aliases PSP
PSPHD
Species Homo sapiens
 Database cross references - PSPH
ExoCarta ExoCarta_5723
Entrez Gene 5723
HGNC 9577
MIM 172480
UniProt P78330  
 PSPH identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PSPH
Molecular Function
    magnesium ion binding GO:0000287 IDA
    phosphoserine phosphatase activity GO:0004647 TAS
    calcium ion binding GO:0005509 IDA
    protein homodimerization activity GO:0042803 IPI
Biological Process
    L-serine biosynthetic process GO:0006564 TAS
    response to nutrient levels GO:0031667 IEA
    small molecule metabolic process GO:0044281 TAS
    response to testosterone GO:0033574 IEA
    response to mechanical stimulus GO:0009612 IEA
    L-serine metabolic process GO:0006563 IDA
    cellular nitrogen compound metabolic process GO:0034641 TAS
    cellular amino acid biosynthetic process GO:0008652 TAS
    dephosphorylation GO:0016311 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IBA
    neuron projection GO:0043005 IEA
 Experiment description of studies that identified PSPH in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PSPH
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRPSAP1 5635
Affinity Capture-MS Homo sapiens
2 DUSP24  
Affinity Capture-MS Homo sapiens
3 PSPH 5723
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
4 ASF1B  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PSPH is involved
PathwayEvidenceSource
Serine biosynthesis TAS Reactome





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