Gene description for TIMM8B
Gene name translocase of inner mitochondrial membrane 8 homolog B (yeast)
Gene symbol TIMM8B
Other names/aliases DDP2
TIM8B
Species Homo sapiens
 Database cross references - TIMM8B
ExoCarta ExoCarta_26521
Vesiclepedia VP_26521
Entrez Gene 26521
HGNC 11818
MIM 606659
UniProt Q9Y5J9  
 TIMM8B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TIMM8B
Molecular Function
    zinc ion binding GO:0008270 TAS
    protein transporter activity GO:0140318 ISS
Biological Process
    protein targeting to mitochondrion GO:0006626 TAS
    sensory perception of sound GO:0007605 TAS
    protein insertion into mitochondrial inner membrane GO:0045039 ISS
    protein insertion into mitochondrial inner membrane GO:0045039 NAS
    protein insertion into mitochondrial inner membrane GO:0045039 TAS
Subcellular Localization
    extracellular space GO:0005615 HDA
    mitochondrion GO:0005739 HTP
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial intermembrane space GO:0005758 NAS
    mitochondrial intermembrane space protein transporter complex GO:0042719 ISS
    mitochondrial intermembrane space protein transporter complex GO:0042719 TAS
 Experiment description of studies that identified TIMM8B in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TIMM8B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DDX6 1656
Co-fractionation Homo sapiens
2 C6orf15  
Affinity Capture-MS Homo sapiens
3 C15orf48  
Affinity Capture-MS Homo sapiens
4 PHB2 11331
Proximity Label-MS Homo sapiens
5 KLC2 64837
Affinity Capture-MS Homo sapiens
6 PDYN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SLC25A12 8604
Proximity Label-MS Homo sapiens
8 AIFM1 9131
Proximity Label-MS Homo sapiens
9 PSPH 5723
Co-fractionation Homo sapiens
10 SOX6  
Proximity Label-MS Homo sapiens
11 ZNF385C  
Affinity Capture-MS Homo sapiens
12 ANKRD9  
Affinity Capture-MS Homo sapiens
13 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
14 NAA50 80218
Co-fractionation Homo sapiens
15 FOXI2  
Affinity Capture-MS Homo sapiens
16 MYO1C 4641
Affinity Capture-MS Homo sapiens
17 LYZL6  
Affinity Capture-MS Homo sapiens
18 SFXN1 94081
Proximity Label-MS Homo sapiens
19 DIABLO 56616
Proximity Label-MS Homo sapiens
20 CAPZB 832
Affinity Capture-MS Homo sapiens
21 C12orf49  
Negative Genetic Homo sapiens
22 TIMM9  
Co-fractionation Homo sapiens
23 PTRH1  
Affinity Capture-MS Homo sapiens
24 TGFB1 7040
Affinity Capture-MS Homo sapiens
25 EGFL8  
Two-hybrid Homo sapiens
26 GPATCH8  
Affinity Capture-MS Homo sapiens
27 FOXQ1  
Affinity Capture-MS Homo sapiens
28 KIAA0368 23392
Co-fractionation Homo sapiens
29 COQ10B  
Affinity Capture-MS Homo sapiens
30 HADHB 3032
Two-hybrid Homo sapiens
31 YBEY  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TIMM13 26517
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which TIMM8B is involved
PathwayEvidenceSource
Mitochondrial protein import IEA Reactome
Protein localization IEA Reactome





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