Gene description for SFXN1
Gene name sideroflexin 1
Gene symbol SFXN1
Other names/aliases -
Species Homo sapiens
 Database cross references - SFXN1
ExoCarta ExoCarta_94081
Entrez Gene 94081
HGNC 16085
MIM 615569
UniProt Q9H9B4  
 SFXN1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for SFXN1
Molecular Function
    ion transmembrane transporter activity GO:0015075 IEA
Biological Process
    iron ion transport GO:0006826 IEA
    ion transmembrane transport GO:0034220 IEA
    erythrocyte differentiation GO:0030218 IEA
    iron ion homeostasis GO:0055072 IEA
Subcellular Localization
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified SFXN1 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SFXN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PGRMC1 10857
Affinity Capture-MS Homo sapiens
2 TSC22D1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SFXN1 is involved
No pathways found





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