Gene description for SERAC1
Gene name serine active site containing 1
Gene symbol SERAC1
Other names/aliases -
Species Homo sapiens
 Database cross references - SERAC1
ExoCarta ExoCarta_84947
Entrez Gene 84947
HGNC 21061
MIM 614725
UniProt Q96JX3  
 SERAC1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SERAC1
Molecular Function
    hydrolase activity, acting on ester bonds GO:0016788 IEA
Biological Process
    extracellular matrix organization GO:0030198 IEA
    GPI anchor metabolic process GO:0006505 IEA
    phospholipid biosynthetic process GO:0008654 IEA
    intracellular protein transport GO:0006886 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    integral component of membrane GO:0016021 IEA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    extracellular matrix GO:0031012 IEA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified SERAC1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SERAC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SERAC1 is involved
No pathways found





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