Gene description for YME1L1
Gene name YME1-like 1 ATPase
Gene symbol YME1L1
Other names/aliases FTSH
MEG4
PAMP
YME1L
Species Homo sapiens
 Database cross references - YME1L1
ExoCarta ExoCarta_10730
Vesiclepedia VP_10730
Entrez Gene 10730
HGNC 12843
MIM 607472
UniProt Q96TA2  
 YME1L1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for YME1L1
Molecular Function
    DNA clamp loader activity GO:0003689 IEA
    ATP-dependent peptidase activity GO:0004176 IBA
    ATP-dependent peptidase activity GO:0004176 IDA
    ATP-dependent peptidase activity GO:0004176 IMP
    metalloendopeptidase activity GO:0004222 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    metal ion binding GO:0046872 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein quality control for misfolded or incompletely synthesized proteins GO:0006515 IBA
    protein quality control for misfolded or incompletely synthesized proteins GO:0006515 IMP
    mitochondrion organization GO:0007005 IBA
    mitochondrion organization GO:0007005 IMP
    cell population proliferation GO:0008283 IMP
    cellular response to starvation GO:0009267 IDA
    positive regulation of mitochondrial fusion GO:0010636 IDA
    protein hexamerization GO:0034214 IDA
    mitochondrial protein processing GO:0034982 IMP
    mitochondrial protein catabolic process GO:0035694 IMP
    negative regulation of apoptotic process GO:0043066 IMP
    neuronal stem cell population maintenance GO:0097150 ISS
    chromatin looping GO:0140588 IEA
    regulation of stem cell division GO:2000035 ISS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IBA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    membrane GO:0016020 HDA
    nuclear body GO:0016604 IDA
 Experiment description of studies that identified YME1L1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for YME1L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPRTN  
Affinity Capture-MS Homo sapiens
2 SLC39A4 55630
Affinity Capture-MS Homo sapiens
3 KIF20A 10112
Affinity Capture-MS Homo sapiens
4 TYROBP  
Affinity Capture-MS Homo sapiens
5 DNAJC25 548645
Affinity Capture-MS Homo sapiens
6 DNAJC15  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
7 COX8A  
Proximity Label-MS Homo sapiens
8 PLEKHG4  
Affinity Capture-MS Homo sapiens
9 FIS1 51024
Proximity Label-MS Homo sapiens
10 UBE2O 63893
Affinity Capture-MS Homo sapiens
11 TIMMDC1  
Affinity Capture-MS Homo sapiens
12 FBXW7  
Affinity Capture-MS Homo sapiens
13 CHCHD10  
Affinity Capture-MS Homo sapiens
14 NR3C1 2908
Proximity Label-MS Homo sapiens
15 SURF1  
Proximity Label-MS Homo sapiens
16 ATP2A3 489
Affinity Capture-MS Homo sapiens
17 Ubr5  
Affinity Capture-MS Mus musculus
18 ATG16L1 55054
Affinity Capture-MS Homo sapiens
19 NDUFA11 126328
Affinity Capture-MS Homo sapiens
20 Kif2c 73804
Affinity Capture-MS Mus musculus
21 DNAJB12 54788
Affinity Capture-MS Homo sapiens
22 AP4E1  
Affinity Capture-MS Homo sapiens
23 KIF14 9928
Affinity Capture-MS Homo sapiens
24 ESR1  
Affinity Capture-MS Homo sapiens
25 TMEM63B 55362
Affinity Capture-MS Homo sapiens
26 DYRK4  
Affinity Capture-MS Homo sapiens
27 UNK  
Affinity Capture-RNA Homo sapiens
28 APOO 79135
Proximity Label-MS Homo sapiens
29 E2F4  
Affinity Capture-MS Homo sapiens
30 KCNK1  
Affinity Capture-MS Homo sapiens
31 ATP5A1 498
Co-fractionation Homo sapiens
32 DNAJB8 165721
Affinity Capture-MS Homo sapiens
33 COX15 1355
Proximity Label-MS Homo sapiens
34 DIABLO 56616
Proximity Label-MS Homo sapiens
35 CTDP1 9150
Affinity Capture-MS Homo sapiens
36 PARK2  
Affinity Capture-MS Homo sapiens
37 Ppp4c 56420
Affinity Capture-MS Mus musculus
38 EIF2B5 8893
Affinity Capture-MS Homo sapiens
39 Pfdn2  
Affinity Capture-MS Mus musculus
40 Vav2  
Affinity Capture-MS Mus musculus
41 PBXIP1 57326
Affinity Capture-MS Homo sapiens
42 OGT 8473
Reconstituted Complex Homo sapiens
43 OPA1 4976
Proximity Label-MS Homo sapiens
44 RAB7A 7879
Proximity Label-MS Homo sapiens
45 HECTD1 25831
Affinity Capture-MS Homo sapiens
46 GEMIN7  
Affinity Capture-MS Homo sapiens
47 RANBP6 26953
Affinity Capture-MS Homo sapiens
48 TMEM70  
Proximity Label-MS Homo sapiens
49 ARHGAP20  
Affinity Capture-MS Homo sapiens
50 COX4I1 1327
Proximity Label-MS Homo sapiens
51 BCL11A 53335
Two-hybrid Homo sapiens
52 ZRANB1 54764
Affinity Capture-MS Homo sapiens
53 SEC63 11231
Affinity Capture-MS Homo sapiens
54 NTRK1 4914
Affinity Capture-MS Homo sapiens
55 PSEN1 5663
Two-hybrid Homo sapiens
56 SLC25A12 8604
Proximity Label-MS Homo sapiens
57 AIFM1 9131
Proximity Label-MS Homo sapiens
58 LRRC61 65999
Affinity Capture-MS Homo sapiens
59 DAP3 7818
Co-fractionation Homo sapiens
60 NDUFA13 51079
Affinity Capture-MS Homo sapiens
61 PTEN 5728
Synthetic Growth Defect Homo sapiens
62 MYOG  
Two-hybrid Homo sapiens
63 ASIC2  
Affinity Capture-MS Homo sapiens
64 CUL3 8452
Affinity Capture-MS Homo sapiens
65 ATP5F1 515
Co-fractionation Homo sapiens
66 FKBP8 23770
Co-fractionation Homo sapiens
67 PHKG2 5261
Affinity Capture-MS Homo sapiens
68 Ncaph  
Affinity Capture-MS Mus musculus
69 RIPK4  
Affinity Capture-MS Homo sapiens
70 OCIAD1 54940
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
71 RPA3 6119
Proximity Label-MS Homo sapiens
72 APOOL 139322
Affinity Capture-MS Homo sapiens
73 DDRGK1 65992
Affinity Capture-MS Homo sapiens
74 ENTHD2  
Affinity Capture-MS Homo sapiens
75 AKAP1 8165
Proximity Label-MS Homo sapiens
76 DOCK3  
Affinity Capture-MS Homo sapiens
77 HIPK4  
Affinity Capture-MS Homo sapiens
78 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
79 PHB2 11331
Proximity Label-MS Homo sapiens
80 NAAA  
Affinity Capture-MS Homo sapiens
81 CCT8 10694
Cross-Linking-MS (XL-MS) Homo sapiens
82 Ercc6l  
Affinity Capture-MS Mus musculus
83 DNAJC19 131118
Affinity Capture-MS Homo sapiens
84 FBXL6  
Affinity Capture-MS Homo sapiens
85 GP9 2815
Affinity Capture-MS Homo sapiens
86 DOCK5 80005
Affinity Capture-MS Homo sapiens
87 ICT1 3396
Affinity Capture-MS Homo sapiens
88 PEX19 5824
Affinity Capture-MS Homo sapiens
89 TBC1D9  
Affinity Capture-MS Homo sapiens
90 OPA3 80207
Affinity Capture-MS Homo sapiens
91 SSBP1 6742
Co-fractionation Homo sapiens
92 PDP2  
Affinity Capture-MS Homo sapiens
93 SFXN1 94081
Proximity Label-MS Homo sapiens
94 TTC25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 CAD 790
Co-fractionation Homo sapiens
96 C19orf52  
Proximity Label-MS Homo sapiens
97 SLC25A51  
Proximity Label-MS Homo sapiens
98 BRD1 23774
Affinity Capture-MS Homo sapiens
99 Tnpo1 238799
Affinity Capture-MS Mus musculus
100 KRAS 3845
Synthetic Lethality Homo sapiens
101 Shcbp1 20419
Affinity Capture-MS Mus musculus
102 C9orf72  
Affinity Capture-MS Homo sapiens
103 VDAC3 7419
Co-fractionation Homo sapiens
104 INTU  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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