Gene description for OPA3
Gene name optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
Gene symbol OPA3
Other names/aliases MGA3
Species Homo sapiens
 Database cross references - OPA3
ExoCarta ExoCarta_80207
Entrez Gene 80207
HGNC 8142
MIM 606580
UniProt Q9H6K4  
 OPA3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for OPA3
Biological Process
    mitochondrion morphogenesis GO:0070584 IEA
    visual perception GO:0007601 IMP
    regulation of lipid metabolic process GO:0019216 IEA
    response to stimulus GO:0050896 IEA
    neuromuscular process GO:0050905 IEA
    growth GO:0040007 IEA
Subcellular Localization
    mitochondrion GO:0005739 NAS
 Experiment description of studies that identified OPA3 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for OPA3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which OPA3 is involved
No pathways found

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