Gene description for OPA3
Gene name optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
Gene symbol OPA3
Other names/aliases MGA3
Species Homo sapiens
 Database cross references - OPA3
ExoCarta ExoCarta_80207
Vesiclepedia VP_80207
Entrez Gene 80207
HGNC 8142
MIM 606580
UniProt Q9H6K4  
 OPA3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for OPA3
Biological Process
    visual perception GO:0007601 IMP
    regulation of lipid metabolic process GO:0019216 IBA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 NAS
 Experiment description of studies that identified OPA3 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for OPA3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NRG1 3084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GYPA  
Affinity Capture-MS Homo sapiens
3 ECH1 1891
Affinity Capture-MS Homo sapiens
4 ATP5J 522
Affinity Capture-MS Homo sapiens
5 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SLC15A1  
Affinity Capture-MS Homo sapiens
7 TMEM9 252839
Affinity Capture-MS Homo sapiens
8 STARD7 56910
Affinity Capture-MS Homo sapiens
9 AIFM1 9131
Proximity Label-MS Homo sapiens
10 PCDHGB6  
Affinity Capture-MS Homo sapiens
11 PHYHIPL  
Affinity Capture-MS Homo sapiens
12 STOML2 30968
Affinity Capture-MS Homo sapiens
13 PCDHGB4 8641
Affinity Capture-MS Homo sapiens
14 ATP5A1 498
Affinity Capture-MS Homo sapiens
15 COX5A 9377
Affinity Capture-MS Homo sapiens
16 PRMT6  
Two-hybrid Homo sapiens
17 UBC 7316
Reconstituted Complex Homo sapiens
18 VSTM1  
Affinity Capture-MS Homo sapiens
19 OPA3 80207
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 APP 351
Reconstituted Complex Homo sapiens
21 NXF1 10482
Affinity Capture-RNA Homo sapiens
22 TNFRSF17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 IDE 3416
Affinity Capture-MS Homo sapiens
24 ACP2 53
Affinity Capture-MS Homo sapiens
25 LAMC1 3915
Affinity Capture-MS Homo sapiens
26 PCDHGB2  
Affinity Capture-MS Homo sapiens
27 TMEM154  
Affinity Capture-MS Homo sapiens
28 KDM1A 23028
Two-hybrid Homo sapiens
29 YME1L1 10730
Affinity Capture-MS Homo sapiens
30 NRD1 4898
Affinity Capture-MS Homo sapiens
31 SCO1  
Affinity Capture-MS Homo sapiens
32 C1QBP 708
Affinity Capture-MS Homo sapiens
33 TIMM23 100287932
Affinity Capture-MS Homo sapiens
34 DDRGK1 65992
Affinity Capture-MS Homo sapiens
35 CLPB 81570
Affinity Capture-MS Homo sapiens
36 SUV39H1  
Two-hybrid Homo sapiens
37 ATP5O 539
Affinity Capture-MS Homo sapiens
38 ATP5C1 509
Affinity Capture-MS Homo sapiens
39 SCO2  
Affinity Capture-MS Homo sapiens
40 MTCH2 23788
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which OPA3 is involved
No pathways found





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