Gene description for NRG1
Gene name neuregulin 1
Gene symbol NRG1
Other names/aliases ARIA
GGF
GGF2
HGL
HRG
HRG1
HRGA
MST131
MSTP131
NDF
NRG1-IT2
SMDF
Species Homo sapiens
 Database cross references - NRG1
ExoCarta ExoCarta_3084
Vesiclepedia VP_3084
Entrez Gene 3084
HGNC 7997
MIM 142445
UniProt Q02297  
 NRG1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NRG1
Molecular Function
    cytokine activity GO:0005125 TAS
    transcription cofactor activity GO:0003712 IDA
    receptor tyrosine kinase binding GO:0030971 NAS
    protein tyrosine kinase activator activity GO:0030296 IDA
    protein binding GO:0005515 IPI
    transmembrane receptor protein tyrosine kinase activator activity GO:0030297 NAS
    receptor binding GO:0005102 IPI
    growth factor activity GO:0008083 NAS
    ErbB-3 class receptor binding GO:0043125 IPI
    ErbB-2 class receptor binding GO:0005176 IEA
Biological Process
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    positive regulation of cardiac muscle cell proliferation GO:0060045 IDA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    positive regulation of Ras protein signal transduction GO:0046579 IEA
    cell proliferation GO:0008283 IDA
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    glial cell fate commitment GO:0021781 IEA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IDA
    endocardial cell differentiation GO:0060956 IDA
    nervous system development GO:0007399 TAS
    cardiac muscle cell differentiation GO:0055007 ISS
    locomotory behavior GO:0007626 IEA
    positive regulation of cell adhesion GO:0045785 IDA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    neural crest cell development GO:0014032 TAS
    embryo development GO:0009790 IEA
    cell migration GO:0016477 IEA
    neurotransmitter receptor metabolic process GO:0045213 IEA
    positive regulation of striated muscle cell differentiation GO:0051155 ISS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    positive regulation of cell growth GO:0030307 IDA
    innate immune response GO:0045087 TAS
    ERBB signaling pathway GO:0038127 IDA
    MAPK cascade GO:0000165 IEA
    peripheral nervous system development GO:0007422 IEA
    intracellular signal transduction GO:0035556 IBA
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IDA
    negative regulation of cardiac muscle cell apoptotic process GO:0010667 IDA
    synapse assembly GO:0007416 IEA
    neuron fate commitment GO:0048663 IEA
    positive regulation of protein kinase B signaling GO:0051897 IEA
    positive regulation of cardiac muscle cell differentiation GO:2000727 IEA
    negative regulation of secretion GO:0051048 IDA
    cell morphogenesis GO:0000902 IEA
    cell communication GO:0007154 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    negative regulation of protein catabolic process GO:0042177 IEA
    cardiac conduction system development GO:0003161 IEA
    ventricular cardiac muscle cell differentiation GO:0055012 IDA
    activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 NAS
    wound healing GO:0042060 TAS
    positive regulation of protein tyrosine kinase activity GO:0061098 IDA
    regulation of protein homodimerization activity GO:0043496 TAS
    regulation of protein heterodimerization activity GO:0043497 IDA
    cellular protein complex disassembly GO:0043624 IGI
    mammary gland development GO:0030879 TAS
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    ventricular trabecula myocardium morphogenesis GO:0003222 IDA
    cardiac muscle cell myoblast differentiation GO:0060379 IDA
Subcellular Localization
    axon GO:0030424 IEA
    membrane GO:0016020 NAS
    neuromuscular junction GO:0031594 IEA
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    integral component of plasma membrane GO:0005887 IEA
    apical plasma membrane GO:0016324 IDA
 Experiment description of studies that identified NRG1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NRG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ERBB2 2064
Reconstituted Complex Homo sapiens
2 ERBB3 2065
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
3 EGFR 1956
Invitro Homo sapiens
4 EGF 1950
Invitro Homo sapiens
5 LIMK1 3984
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



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