Gene description for SFXN3
Gene name sideroflexin 3
Gene symbol SFXN3
Other names/aliases BA108L7.2
SFX3
Species Homo sapiens
 Database cross references - SFXN3
ExoCarta ExoCarta_81855
Vesiclepedia VP_81855
Entrez Gene 81855
HGNC 16087
MIM 615571
UniProt Q9BWM7  
 SFXN3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SFXN3
Molecular Function
    protein binding GO:0005515 IPI
    monoatomic ion transmembrane transporter activity GO:0015075 IEA
    L-serine transmembrane transporter activity GO:0015194 IDA
    transmembrane transporter activity GO:0022857 IBA
Biological Process
    one-carbon metabolic process GO:0006730 IDA
    L-serine transport GO:0015825 IEA
    monoatomic ion transmembrane transport GO:0034220 IEA
    serine import into mitochondrion GO:0140300 IBA
    serine import into mitochondrion GO:0140300 IDA
    mitochondrial transmembrane transport GO:1990542 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IBA
 Experiment description of studies that identified SFXN3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SFXN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAMP3  
Affinity Capture-MS Homo sapiens
2 HSD17B11 51170
Two-hybrid Homo sapiens
3 TIMM17A  
Co-fractionation Homo sapiens
4 LAMP3  
Affinity Capture-MS Homo sapiens
5 PDCD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TMEM184A  
Affinity Capture-MS Homo sapiens
7 LAMP2 3920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 VAMP2 6844
Co-fractionation Homo sapiens
9 KLRB1  
Affinity Capture-MS Homo sapiens
10 NDUFA4 4697
Affinity Capture-MS Homo sapiens
11 NUFIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 LRRN4CL 221091
Affinity Capture-MS Homo sapiens
13 FFAR1  
Affinity Capture-MS Homo sapiens
14 PDE2A  
Affinity Capture-MS Homo sapiens
15 TOMM22 56993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
16 KIAA1429 25962
Affinity Capture-MS Homo sapiens
17 PJA1  
Affinity Capture-MS Homo sapiens
18 NDUFS3 4722
Affinity Capture-MS Homo sapiens
19 B3GNT2 10678
Affinity Capture-MS Homo sapiens
20 DYRK1A 1859
Affinity Capture-MS Homo sapiens
21 FAM174A 345757
Affinity Capture-MS Homo sapiens
22 GLMP 112770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 THTPA  
Affinity Capture-MS Homo sapiens
24 GPBAR1  
Affinity Capture-MS Homo sapiens
25 SURF1  
Co-fractionation Homo sapiens
26 VDAC1 7416
Co-fractionation Homo sapiens
27 TRIM16L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MECP2 4204
Affinity Capture-MS Homo sapiens
29 TIMM50 92609
Co-fractionation Homo sapiens
30 UQCRQ 27089
Co-fractionation Homo sapiens
31 LEPROTL1 23484
Two-hybrid Homo sapiens
32 KIF14 9928
Affinity Capture-MS Homo sapiens
33 BSG 682
Affinity Capture-MS Homo sapiens
34 EFNA2  
Affinity Capture-MS Homo sapiens
35 KCNK1  
Affinity Capture-MS Homo sapiens
36 FCER1G 2207
Two-hybrid Homo sapiens
37 MPV17 4358
Co-fractionation Homo sapiens
38 TMEM14B  
Two-hybrid Homo sapiens
39 REEP4  
Two-hybrid Homo sapiens
40 TARBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 STOM 2040
Co-fractionation Homo sapiens
42 TMEM150A  
Affinity Capture-MS Homo sapiens
43 TUFM 7284
Co-fractionation Homo sapiens
44 ALPI  
Affinity Capture-MS Homo sapiens
45 Nfya  
Affinity Capture-MS Mus musculus
46 C16orf58 64755
Two-hybrid Homo sapiens
47 NTRK1 4914
Affinity Capture-MS Homo sapiens
48 GPR182  
Affinity Capture-MS Homo sapiens
49 CREB3  
Two-hybrid Homo sapiens
50 PML 5371
Affinity Capture-MS Homo sapiens
51 TMEM63A 9725
Affinity Capture-MS Homo sapiens
52 TMEM56  
Two-hybrid Homo sapiens
53 RAB4B 53916
Affinity Capture-MS Homo sapiens
54 SCN3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
55 VDAC2 7417
Co-fractionation Homo sapiens
56 CYLD  
Affinity Capture-MS Homo sapiens
57 SPRYD7 57213
Affinity Capture-MS Homo sapiens
58 DNAAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 ACAT1 38
Co-fractionation Homo sapiens
60 SLC15A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 APLNR  
Affinity Capture-MS Homo sapiens
62 FANCD2  
Affinity Capture-MS Homo sapiens
63 TNFSF8  
Affinity Capture-MS Homo sapiens
64 LRRC25  
Affinity Capture-MS Homo sapiens
65 NPTN 27020
Affinity Capture-MS Homo sapiens
66 CMKLR1 1240
Affinity Capture-MS Homo sapiens
67 MGARP  
Affinity Capture-MS Homo sapiens
68 SRSF5 6430
Co-fractionation Homo sapiens
69 EGFR 1956
Affinity Capture-MS Homo sapiens
70 KLRD1  
Affinity Capture-MS Homo sapiens
71 HSD17B13  
Two-hybrid Homo sapiens
72 AQP3  
Affinity Capture-MS Homo sapiens
73 NXF1 10482
Affinity Capture-RNA Homo sapiens
74 SYP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 FAM134C 162427
Two-hybrid Homo sapiens
76 RPA3 6119
Proximity Label-MS Homo sapiens
77 ALDH3B2  
Affinity Capture-MS Homo sapiens
78 DLST 1743
Affinity Capture-MS Homo sapiens
79 ASPH 444
Affinity Capture-MS Homo sapiens
80 PLP2 5355
Co-fractionation Homo sapiens
81 CST9L  
Affinity Capture-MS Homo sapiens
82 ILK 3611
Affinity Capture-MS Homo sapiens
83 XRCC3  
Affinity Capture-MS Homo sapiens
84 ISLR 3671
Affinity Capture-MS Homo sapiens
85 ASXL1  
Affinity Capture-MS Homo sapiens
86 SLC22A4 6583
Affinity Capture-MS Homo sapiens
87 ZMYM2  
Affinity Capture-MS Homo sapiens
88 TOMM20 9804
Co-fractionation Homo sapiens
89 HUWE1 10075
Affinity Capture-MS Homo sapiens
90 TMX2 51075
Two-hybrid Homo sapiens
91 Gbf1  
Affinity Capture-MS Mus musculus
92 NRG1 3084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 MAGEA8  
Affinity Capture-MS Homo sapiens
94 KCNE1  
Affinity Capture-MS Homo sapiens
95 TMEM51 55092
Two-hybrid Homo sapiens
96 FCGR3B  
Affinity Capture-MS Homo sapiens
97 SPTAN1 6709
Co-fractionation Homo sapiens
98 NAAA  
Affinity Capture-MS Homo sapiens
99 TOR1AIP2 163590
Affinity Capture-MS Homo sapiens
100 GP9 2815
Affinity Capture-MS Homo sapiens
101 Atp7a  
Affinity Capture-MS Mus musculus
102 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
103 DNAJA2 10294
Affinity Capture-MS Homo sapiens
104 LRRC55  
Affinity Capture-MS Homo sapiens
105 OSTM1 28962
Affinity Capture-MS Homo sapiens
106 ALPPL2 251
Affinity Capture-MS Homo sapiens
107 FAM3C 10447
Co-fractionation Homo sapiens
108 PDHA1 5160
Affinity Capture-MS Homo sapiens
109 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
110 TMEM108  
Affinity Capture-MS Homo sapiens
111 EDEM2  
Affinity Capture-MS Homo sapiens
112 SFXN1 94081
Co-fractionation Homo sapiens
113 CD80 941
Affinity Capture-MS Homo sapiens
114 CLEC12B  
Affinity Capture-MS Homo sapiens
115 MOV10 4343
Affinity Capture-RNA Homo sapiens
116 ITGB7 3695
Affinity Capture-MS Homo sapiens
117 LAMB3 3914
Affinity Capture-MS Homo sapiens
118 SLC1A1 6505
Affinity Capture-MS Homo sapiens
119 CLEC4E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 ESYT1 23344
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which SFXN3 is involved
No pathways found





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