Gene description for UQCRQ
Gene name ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
Gene symbol UQCRQ
Other names/aliases MC3DN4
QCR8
QP-C
QPC
UQCR7
Species Homo sapiens
 Database cross references - UQCRQ
ExoCarta ExoCarta_27089
Vesiclepedia VP_27089
Entrez Gene 27089
HGNC 29594
MIM 612080
UniProt O14949  
 UQCRQ identified in exosomes derived from the following tissue/cell type
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for UQCRQ
Biological Process
    mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 IBA
    mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 NAS
    subthalamus development GO:0021539 IEA
    pons development GO:0021548 IEA
    cerebellar Purkinje cell layer development GO:0021680 IEA
    hippocampus development GO:0021766 IEA
    thalamus development GO:0021794 IEA
    hypothalamus development GO:0021854 IEA
    pyramidal neuron development GO:0021860 IEA
    midbrain development GO:0030901 IEA
    cellular respiration GO:0045333 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    respiratory chain complex III GO:0045275 IBA
 Experiment description of studies that identified UQCRQ in exosomes
1
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UQCRQ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 AFG3L2 10939
Co-fractionation Homo sapiens
4 FAM131B  
Affinity Capture-MS Homo sapiens
5 UQCRFS1 7386
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
6 RAB1A 5861
Co-fractionation Homo sapiens
7 NDUFS1 4719
Co-fractionation Homo sapiens
8 Dctn1 13191
Affinity Capture-MS Mus musculus
9 TMEM184A  
Affinity Capture-MS Homo sapiens
10 UQCRB 7381
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 UQCR10 29796
Affinity Capture-MS Homo sapiens
12 NDUFA4 4697
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
13 FFAR1  
Affinity Capture-MS Homo sapiens
14 NDUFS2 4720
Co-fractionation Homo sapiens
15 TOMM22 56993
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
16 NDUFS3 4722
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
17 SYT6  
Affinity Capture-MS Homo sapiens
18 OGDH 4967
Co-fractionation Homo sapiens
19 TFAM 7019
Co-fractionation Homo sapiens
20 NDUFB8 4714
Co-fractionation Homo sapiens
21 COX7A2L 9167
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TRABD 80305
Affinity Capture-MS Homo sapiens
23 IQGAP1 8826
Co-fractionation Homo sapiens
24 COA3 28958
Co-fractionation Homo sapiens
25 DDOST 1650
Co-fractionation Homo sapiens
26 COX7B2  
Affinity Capture-MS Homo sapiens
27 LAMTOR3 8649
Co-fractionation Homo sapiens
28 C20orf24  
Co-fractionation Homo sapiens
29 NDUFV1 4723
Co-fractionation Homo sapiens
30 ATG16L1 55054
Affinity Capture-MS Homo sapiens
31 TOMM40 10452
Co-fractionation Homo sapiens
32 CLTC 1213
Co-fractionation Homo sapiens
33 CANX 821
Co-fractionation Homo sapiens
34 ATP5H 10476
Co-fractionation Homo sapiens
35 WIF1 11197
Affinity Capture-MS Homo sapiens
36 NAT8B  
Affinity Capture-MS Homo sapiens
37 CYSTM1 84418
Co-fractionation Homo sapiens
38 CPT2 1376
Co-fractionation Homo sapiens
39 COX1 4512
Affinity Capture-MS Homo sapiens
40 FAF2 23197
Co-fractionation Homo sapiens
41 NDUFS5 4725
Co-fractionation Homo sapiens
42 SLC25A3 5250
Co-fractionation Homo sapiens
43 RAB1B 81876
Co-fractionation Homo sapiens
44 LMAN1 3998
Co-fractionation Homo sapiens
45 STOML2 30968
Co-fractionation Homo sapiens
46 PTGES2 80142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TMEM248 55069
Affinity Capture-MS Homo sapiens
48 HAUS2  
Affinity Capture-MS Homo sapiens
49 IGHA1 3493
Affinity Capture-MS Homo sapiens
50 MTCH2 23788
Co-fractionation Homo sapiens
51 IGHA2 3494
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 NDUFB7 4713
Co-fractionation Homo sapiens
53 PHB 5245
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
54 SFXN3 81855
Co-fractionation Homo sapiens
55 HSP90B1 7184
Co-fractionation Homo sapiens
56 OPTN 10133
Reconstituted Complex Homo sapiens
57 ILVBL 10994
Co-fractionation Homo sapiens
58 CST1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 TUBA1C 84790
Affinity Capture-MS Homo sapiens
60 DNAJA1 3301
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
61 CYC1 1537
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
62 UQCRC1 7384
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
63 PML 5371
Affinity Capture-MS Homo sapiens
64 UQCRH 7388
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 VDAC2 7417
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
66 NIPSNAP1 8508
Co-fractionation Homo sapiens
67 ATP5B 506
Co-fractionation Homo sapiens
68 COX4I1 1327
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
69 IMMT 10989
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
70 C15orf48  
Affinity Capture-MS Homo sapiens
71 ACAT1 38
Co-fractionation Homo sapiens
72 SGPL1 8879
Co-fractionation Homo sapiens
73 HADHB 3032
Co-fractionation Homo sapiens
74 HADHA 3030
Co-fractionation Homo sapiens
75 MINOS1  
Co-fractionation Homo sapiens
76 CDC73  
Affinity Capture-MS Homo sapiens
77 ATP5F1 515
Co-fractionation Homo sapiens
78 SDHA 6389
Co-fractionation Homo sapiens
79 CYTB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 UQCRC2 7385
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
81 GOLT1B 51026
Affinity Capture-MS Homo sapiens
82 NR3C1 2908
Proximity Label-MS Homo sapiens
83 COX6A1  
Affinity Capture-MS Homo sapiens
84 CIART  
Affinity Capture-MS Homo sapiens
85 COX6B1 1340
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 CORO1C 23603
Co-fractionation Homo sapiens
87 POLR2M  
Two-hybrid Homo sapiens
88 TROVE2 6738
Co-fractionation Homo sapiens
89 ZNF782  
Co-fractionation Homo sapiens
90 ANKRD34C  
Co-fractionation Homo sapiens
91 ATP5J2 9551
Co-fractionation Homo sapiens
92 CST4 1472
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 RPA3 6119
Proximity Label-MS Homo sapiens
94 NLRP3  
Affinity Capture-MS Homo sapiens
95 ATP2A1 487
Affinity Capture-MS Homo sapiens
96 TMCO1 54499
Co-fractionation Homo sapiens
97 ATP6V1A 523
Co-fractionation Homo sapiens
98 ATP1B1 481
Co-fractionation Homo sapiens
99 DDRGK1 65992
Affinity Capture-MS Homo sapiens
100 NDUFA9 4704
Co-fractionation Homo sapiens
101 NDUFA10 4705
Co-fractionation Homo sapiens
102 XRCC3  
Affinity Capture-MS Homo sapiens
103 COX2 4513
Co-fractionation Homo sapiens
104 SLC22A4 6583
Affinity Capture-MS Homo sapiens
105 SCCPDH 51097
Co-fractionation Homo sapiens
106 NRG1 3084
Affinity Capture-MS Homo sapiens
107 MAGEA8  
Affinity Capture-MS Homo sapiens
108 FTL 2512
Affinity Capture-MS Homo sapiens
109 EIF3F 8665
Affinity Capture-MS Homo sapiens
110 PHB2 11331
Co-fractionation Homo sapiens
111 ALDH3A2 224
Co-fractionation Homo sapiens
112 FBXL6  
Affinity Capture-MS Homo sapiens
113 ATP5L 10632
Co-fractionation Homo sapiens
114 COX4I2 84701
Affinity Capture-MS Homo sapiens
115 PDCD6IP 10015
Co-fractionation Homo sapiens
116 ALDH1B1 219
Co-fractionation Homo sapiens
117 PDHA1 5160
Co-fractionation Homo sapiens
118 DNAJA3 9093
Co-fractionation Homo sapiens
119 NDUFS7 374291
Co-fractionation Homo sapiens
120 PDHB 5162
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
121 BPIFA2 140683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 ATP2A2 488
Co-fractionation Homo sapiens
123 SSBP1 6742
Co-fractionation Homo sapiens
124 SFXN1 94081
Co-fractionation Homo sapiens
125 GLB1L3  
Affinity Capture-MS Homo sapiens
126 UFL1 23376
Affinity Capture-MS Homo sapiens
127 NDUFS8 4728
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
128 NDUFA2 4695
Co-fractionation Homo sapiens
129 GPD2 2820
Co-fractionation Homo sapiens
130 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 TOMM5  
Co-fractionation Homo sapiens
132 RAB7A 7879
Affinity Capture-MS Homo sapiens
133 ATP1A1 476
Co-fractionation Homo sapiens
134 COX7A2 1347
Co-fractionation Homo sapiens
135 HNRNPA1L2 144983
Affinity Capture-MS Homo sapiens
136 MCU 90550
Co-fractionation Homo sapiens
137 CLPTM1L 81037
Co-fractionation Homo sapiens
138 ATP5C1 509
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
139 COX7C 1350
Co-fractionation Homo sapiens
140 VDAC3 7419
Co-fractionation Homo sapiens
141 UQCR11  
Co-fractionation Homo sapiens
142 MGST3 4259
Co-fractionation Homo sapiens
143 C17orf59 54785
Affinity Capture-MS Homo sapiens
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