Gene description for PTGES2
Gene name prostaglandin E synthase 2
Gene symbol PTGES2
Other names/aliases C9orf15
GBF-1
GBF1
PGES2
mPGES-2
Species Homo sapiens
 Database cross references - PTGES2
ExoCarta ExoCarta_80142
Entrez Gene 80142
HGNC 17822
MIM 608152
UniProt Q9H7Z7  
 PTGES2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PTGES2
Molecular Function
    glutathione binding GO:0043295 ISS
    lyase activity GO:0016829 ISS
    prostaglandin-E synthase activity GO:0050220 IEA
    protein disulfide oxidoreductase activity GO:0015035 IEA
    heme binding GO:0020037 ISS
    electron carrier activity GO:0009055 IEA
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of transcription, DNA-templated GO:0045893 IEA
    prostaglandin biosynthetic process GO:0001516 IEA
    secretion GO:0046903 IEA
    cell redox homeostasis GO:0045454 IEA
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    mitochondrion GO:0005739 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    nucleus GO:0005634 IEA
    cytosol GO:0005829 IEA
    integral component of membrane GO:0016021 IEA
    Golgi membrane GO:0000139 IEA
 Experiment description of studies that identified PTGES2 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTGES2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EXOSC10  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PTGES2 is involved
No pathways found





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