Gene description for USP1
Gene name ubiquitin specific peptidase 1
Gene symbol USP1
Other names/aliases UBP
Species Homo sapiens
 Database cross references - USP1
ExoCarta ExoCarta_7398
Vesiclepedia VP_7398
Entrez Gene 7398
HGNC 12607
MIM 603478
UniProt O94782  
 USP1 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for USP1
Molecular Function
    cysteine-type endopeptidase activity GO:0004197 IEA
    cysteine-type deubiquitinase activity GO:0004843 IBA
    cysteine-type deubiquitinase activity GO:0004843 IDA
    cysteine-type deubiquitinase activity GO:0004843 IMP
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 EXP
Biological Process
    skeletal system development GO:0001501 IEA
    DNA repair GO:0006281 IEA
    regulation of DNA repair GO:0006282 IDA
    proteolysis GO:0006508 IEA
    response to UV GO:0009411 IDA
    protein deubiquitination GO:0016579 IDA
    regulation of protein stability GO:0031647 IBA
    monoubiquitinated protein deubiquitination GO:0035520 IMP
    positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IDA
    positive regulation of error-prone translesion synthesis GO:1904333 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IBA
 Experiment description of studies that identified USP1 in exosomes
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for USP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Wdr48  
Affinity Capture-MS Mus musculus
2 KRT4 3851
Affinity Capture-MS Homo sapiens
3 CHIC1  
Affinity Capture-MS Homo sapiens
4 LYZ 4069
Affinity Capture-MS Homo sapiens
5 UBE2A  
Co-fractionation Homo sapiens
6 USP43  
Affinity Capture-MS Homo sapiens
7 STAT2 6773
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SHPRH  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 WDR20 91833
Affinity Capture-MS Homo sapiens
10 KPNA1 3836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 KRT17 3872
Affinity Capture-MS Homo sapiens
12 LRRC15 131578
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 KPNB1 3837
Affinity Capture-MS Homo sapiens
14 UBC 7316
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
15 CSE1L 1434
Co-fractionation Homo sapiens
16 KPNA2 3838
Affinity Capture-MS Homo sapiens
17 RIPK1 8737
Affinity Capture-Western Homo sapiens
18 ALDH16A1 126133
Affinity Capture-MS Homo sapiens
19 FZR1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 VPS26A 9559
Co-fractionation Homo sapiens
21 WDR48 57599
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 DTX3  
Two-hybrid Homo sapiens
23 UBE2K 3093
Biochemical Activity Homo sapiens
24 RSRP1  
Affinity Capture-MS Homo sapiens
25 ATAD5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
26 FLG 2312
Affinity Capture-MS Homo sapiens
27 ANAPC1 64682
Affinity Capture-Western Homo sapiens
28 SPANXN5  
Affinity Capture-MS Homo sapiens
29 PHF7  
Two-hybrid Homo sapiens
30 CUL1 8454
Affinity Capture-MS Homo sapiens
31 WDR5 11091
Co-fractionation Homo sapiens
32 UNC45A 55898
Co-fractionation Homo sapiens
33 TAZ  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
34 PTGES2 80142
Affinity Capture-MS Homo sapiens
35 KIT 3815
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
36 USP12 219333
Affinity Capture-MS Homo sapiens
37 DSG1 1828
Affinity Capture-MS Homo sapiens
38 RAD51AP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
39 KLHDC2  
Biochemical Activity Homo sapiens
Protein-peptide Homo sapiens
40 BAG6 7917
Affinity Capture-MS Homo sapiens
41 SOCS6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 MYH9 4627
Affinity Capture-MS Homo sapiens
43 CIRBP 1153
Affinity Capture-MS Homo sapiens
44 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
45 PLK1 5347
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
46 ULK1  
Affinity Capture-Western Homo sapiens
47 SPANXN2  
Affinity Capture-MS Homo sapiens
48 CALML5 51806
Affinity Capture-MS Homo sapiens
49 ID2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 CALML3 810
Affinity Capture-MS Homo sapiens
51 PHLPP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CERK 64781
Affinity Capture-MS Homo sapiens
53 NFAT5  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
54 FANCD2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
55 TP53BP1 7158
Negative Genetic Homo sapiens
56 SGOL1  
Affinity Capture-MS Homo sapiens
57 PHLPP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 MGARP  
Affinity Capture-MS Homo sapiens
59 TRAF6 7189
Two-hybrid Homo sapiens
60 PTEN 5728
Negative Genetic Homo sapiens
61 LGALS7 3963
Affinity Capture-MS Homo sapiens
62 TRAF3 7187
Affinity Capture-Western Homo sapiens
63 TAGLN 6876
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
64 SGTB  
Affinity Capture-MS Homo sapiens
65 HIBADH 11112
Affinity Capture-MS Homo sapiens
66 RPS16 6217
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
67 TRIM46 80128
Two-hybrid Homo sapiens
68 VPS36 51028
Co-fractionation Homo sapiens
69 UBE3B 89910
Affinity Capture-MS Homo sapiens
70 FASN 2194
Positive Genetic Homo sapiens
71 JUP 3728
Affinity Capture-MS Homo sapiens
72 USP46 64854
Affinity Capture-MS Homo sapiens
73 TP53 7157
Synthetic Growth Defect Homo sapiens
74 USP1 7398
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 ZEB1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
76 OPALIN  
Affinity Capture-MS Homo sapiens
77 RPS18 6222
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
78 RPS4X 6191
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
79 DSC1 1823
Affinity Capture-MS Homo sapiens
80 HSPB1 3315
Affinity Capture-MS Homo sapiens
81 CAPNS1 826
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
82 KATNA1 11104
Affinity Capture-MS Homo sapiens
83 TOR1AIP1 26092
Affinity Capture-MS Homo sapiens
84 PKP1 5317
Affinity Capture-MS Homo sapiens
85 PCNA 5111
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
86 ANXA2P2 304
Affinity Capture-MS Homo sapiens
87 TBK1 29110
Affinity Capture-Western Homo sapiens
88 TAGLN2 8407
Affinity Capture-MS Homo sapiens
89 Dctn3  
Affinity Capture-MS Mus musculus
90 Pip4k2c  
Affinity Capture-MS Mus musculus
91 SORT1 6272
Affinity Capture-MS Homo sapiens
92 ZCCHC10  
Affinity Capture-MS Homo sapiens
93 C9orf72  
Affinity Capture-MS Homo sapiens
94 FANCI 55215
Biochemical Activity Homo sapiens
95 USP4 7375
Affinity Capture-MS Homo sapiens
96 BCR 613
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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